ORCID Profile
0000-0002-0956-2777
Current Organisation
National University of Singapore Faculty of Engineering
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In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Macromolecular materials | Colloid and surface chemistry | Macromolecular and materials chemistry | Nanofabrication growth and self assembly
Publisher: Wiley
Date: 06-04-2020
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5CC03603H
Abstract: A polymer and silica co-protection strategy has been developed to encapsulate organic fluorogens with aggregation-induced emission and charge transfer characteristics into small nanoparticles (NPs).
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: Wiley
Date: 26-05-2017
Abstract: Two-photon photodynamic therapy (PDT) is able to offer precise 3D manipulation of treatment volumes, providing a target level that is unattainable with current therapeutic techniques. The advancement of this technique is greatly h ered by the availability of photosensitizers with large two-photon absorption (TPA) cross section, high reactive-oxygen-species (ROS) generation efficiency, and bright two-photon fluorescence. Here, an effective photosensitizer with aggregation-induced emission (AIE) characteristics is synthesized, characterized, and encapsulated into an hiphilic block copolymer to form organic dots for two-photon PDT applications. The AIE dots possess large TPA cross section, high ROS generation efficiency, and excellent photostability and biocompatibility, which overcomes the limitations of many conventional two-photon photosensitizers. Outstanding therapeutic performance of the AIE dots in two-photon PDT is demonstrated using in vitro cancer cell ablation and in vivo brain-blood-vessel closure as ex les. This shows therapy precision up to 5 µm under two-photon excitation.
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0NA00182A
Abstract: Metal-enhancement study of dual functional AIE-photosensitizers unrevealing the intrinsic correlation between MEF and ME-SOG in the AgNP@AIE-PS nanohybrid system.
Publisher: American Chemical Society (ACS)
Date: 23-12-2015
Abstract: Fluorogens with aggregation-induced emission (AIEgens) have emerged as a powerful and versatile platform for the development of novel biosensors. In this study, a series of water-soluble fluorescent probes based on tetraphenylethylene (TPE) were designed and synthesized for the detection of monoamine oxidases (MAOs) based on specific interactions between the probes and the proteins. Among the six probes developed, t-TPEM displays a significant fluorescence increase upon introduction of MAOs. Of particular significance is that the fluorescence of t-TPEM in the presence of MAO-A is 21-fold higher than other proteins including MAO-B. Lineweaver-Burk plots reveal that t-TPEM acts as an uncompetitive inhibitor of MAO-A with Ki = 17.1 μM, which confirms its good binding affinity toward MAO-A. Furthermore, a cell imaging experiment reveals that t-TPEM is able to selectively monitor the activity of MAO-A which is localized in mitochondria of MCF-7 cells.
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: Wiley
Date: 02-11-2016
Abstract: A new bottom-up nanocrystallization method is developed to fabricate highly fluorescent organic nanocrystals in aqueous media using an aggregation-induced emission fluorogen (AIEgen) as an ex le. The nanocrystallization strategy leads to the fabrication of uniform nanocrystals of 110 ± 10 nm size in aqueous media, which shows over 400% increase in brightness as compared to the amorphous nanoaggregates.
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: Wiley
Date: 30-04-2018
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: Wiley
Date: 25-05-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2019
DOI: 10.1021/ACS.ANALCHEM.9B01053
Abstract: Tumor-associated macrophages (TAMs) that exist in tumor microenvironment promote tumor progression and have been suggested as a promising therapeutic target for cancer therapy in preclinical studies. Development of theranostic systems capable of specific targeting, imaging, and ablation of TAMs will offer clinical benefits. Here we constructed a theranostic probe, namely, TPE-Man, by attaching mannose moieties to a red-emissive and AIE (aggregation-induced emission)-active photosensitizer. TPE-Man can specifically recognize a mannose receptor that is overexpressed on TAMs by the sugar-receptor interaction and enables fluorescent visualization of the mannose-receptor-positive TAMs in high contrast. The histologic study of mouse tumor sections further verifies TPE-Man's excellent targeting specificity being comparable with the commercial mannose-receptor antibody. TAMs can be effectively eradicated upon exposure to white light irradiation via a photodynamic therapy effect. To our knowledge, this is the first small molecular theranostic probe for TAMs that revealed combined advantages of low cost, high targeting specificity, fluorescent light-up imaging, and efficient photodynamic ablation.
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
DOI: 10.1021/JACS.0C06516
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C6SC03859J
Abstract: An AIEgen-based theranostic system is developed to lify the antitumor efficacy of paclitaxel with a synergistic effect of “0 + 1 1”.
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 22-12-2018
DOI: 10.1021/ACS.ANALCHEM.7B03694
Abstract: Transferrin receptor (TfR) is overexpressed on the surface of many cancer cells due to its vital roles in iron circulation and cellular respiration. Soluble transferrin receptor (sTfR), a truncated extracellular form of TfR in serum, is an important marker of iron deficiency anemia (IDA) and bone marrow failure in cancer patients. More recently, sTfR level in urine has been related to a specific kidney disease of Henoch-Schönlein purpura nephritis (HSPN). Despite the universal significance of sTfR, there is still a lack of a simple and sensitive method for the quantification of sTfR. Furthermore, it is desirable to have a probe that can detect both TfR and sTfR for further comparison study. In this work, we developed a water-soluble AIE-peptide conjugate with aggregation-induced emission (AIE) characteristics. Taking advantage of the negligible emission from molecularly dissolved tetraphenylethene (TPE), probe TPE-2T7 was used for the light-up detection of sTfR. The probe itself is nonemissive in aqueous solution, but it turns on its fluorescence upon interaction with sTfR to yield a detection limit of 0.27 μg/mL, which is much lower than the sTfR level in IDA patients. Furthermore, a proof-of-concept experiment validates the potential of the probe for diagnosis of HSPN by urine test.
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 11-08-2020
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 21-07-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: Wiley
Date: 21-01-2019
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: Wiley
Date: 21-10-2013
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: American Chemical Society (ACS)
Date: 13-07-2020
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: Wiley
Date: 27-10-2014
Abstract: Real-time imaging of cell-surface-associated proteolytic enzymes is critical to better understand their performances in both physiological and pathological processes. However, most current approaches are limited by their complexity and poor membrane-anchoring properties. Herein, we have designed and synthesized a unique small-molecule fluorescent probe, which combines the principles of passive exogenous membrane insertion and Förster resonance energy transfer (FRET) to image cell-surface-localized furin-like convertase activities. The membrane-associated furin-like enzymatic cleavage of the peptide probe leads to an increased fluorescence intensity which was mainly localized on the plasma membrane of the furin-expressed cells. This small-molecule fluorescent probe may serve as a unique and reliable reporter for real-time visualization of endogenous cell-surfaceassociated proteolytic furin-like enzyme functions in live cells and tissues using one-photon and two-photon microscopy.
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: Wiley
Date: 25-05-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: Wiley
Date: 30-03-2015
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: Wiley
Date: 23-03-2018
Abstract: Pressure ulcers are a chronic problem for patients or the elderly who require extended periods of bed rest. The formation of ulcers is due to repeated cycles of ischemia-reperfusion (IR), which initiates an inflammatory response. Advanced ulcers disrupt the skin barrier, resulting in further complications. To date, the immunological aspect of skin IR has been understudied, partly due to the complexity of the skin immune cells. Through a combination of mass cytometry, confocal imaging and intravital multiphoton imaging, this study establishes a workflow for multidimensionality single cell analysis of skin myeloid cell responses in the context of IR injury with high spatiotemporal resolution. The data generated has provided us with previously uncharacterized insights into the distinct cellular behavior of resident dendritic cells (DCs) and recruited neutrophils post IR. Of interest, we observed a drop in DDC numbers in the IR region, which was subsequently replenished 48h post IR. More importantly, in these cells, we observe an attenuated response to repeated injuries, which may have implications in the subsequent wound healing process.
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0TC90119A
Abstract: Fengyan Song, Bin Liu and Ben Zhong Tang introduce the celebration of the 20th anniversary of aggregation-induced emission with research highlights from Royal Society of Chemistry journals.
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: Wiley
Date: 29-07-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7FD90003A
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 24-07-2023
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: American Chemical Society (ACS)
Date: 14-02-2019
Abstract: Two-photon excited photodynamic therapy (2PE-PDT) has attracted great attention in recent years due to its great potential for deep-tissue and highly spatiotemporally precise cancer therapy. Photosensitizers (PSs) with high singlet oxygen (
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1SC00045D
Abstract: AIE fluorogens provide new opportunities for the development of light-up probes for photodynamic therapy.
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7FD90004J
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9TB02848J
Abstract: A lipid-droplet-specific AIEgen was used to evaluate the inhibitory efficacy of HIF-1-targeting drugs by assessing lipid-droplet levels.
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 02-07-2015
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 26-02-2014
DOI: 10.1021/CM4040374
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
DOI: 10.1021/JACS.0C04253
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8TB00386F
Abstract: Organic nanoparticles with a high quantum yield of 90% and aggregation-induced emission characteristics were prepared for cellular imaging and real-time two-photon vasculature imaging of the lungs.
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 10-2020
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C7NR09196F
Abstract: Bright polymeric AIE nanorods with higher tumor accumulation and more efficient tumor cell uptake are reported for enhanced cancer imaging.
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: Springer Science and Business Media LLC
Date: 16-01-2021
DOI: 10.1007/S40820-020-00583-2
Abstract: Dual-functional aggregation-induced photosensitizers (AIE-PSs) with singlet oxygen generation (SOG) ability and bright fluorescence in aggregated state have received much attention in image-guided photodynamic therapy (PDT). However, designing an AIE-PS with both high SOG and intense fluorescence via molecular design is still challenging. In this work, we report a new nanohybrid consisting of gold nanostar (AuNS) and AIE-PS dots with enhanced fluorescence and photosensitization for theranostic applications. The spectral overlap between the extinction of AuNS and fluorescence emission of AIE-PS dots (665 nm) is carefully selected using five different AuNSs with distinct localized surface plasmon (LSPR) peaks. Results show that all the AuNSs can enhance the 1 O 2 production of AIE-PS dots, among which the AuNS with LSPR peak at 585 nm exhibited the highest 1 O 2 enhancement factor of 15-fold with increased fluorescence brightness. To the best of our knowledge, this is the highest enhancement factor reported for the metal-enhanced singlet oxygen generation systems. The Au585@AIE-PS nanodots were applied for simultaneous fluorescence imaging and photodynamic ablation of HeLa cancer cells with strongly enhanced PDT efficiency in vitro. This study provides a better understanding of the metal-enhanced AIE-PS nanohybrid systems, opening up new avenue towards advanced image-guided PDT with greatly improved efficacy.
Publisher: Wiley
Date: 24-05-2019
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0QM00469C
Abstract: Development of a AgNP@AIE photosensitizer with greatly enhanced singlet oxygen generation (SOG) for effective photodynamic therapy and improved photostability for bright fluorescence bioimaging.
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: Elsevier BV
Date: 2018
DOI: 10.1016/J.BIOMATERIALS.2017.10.031
Abstract: The study of blood brain barrier (BBB) functions is important for neurological disorder research. However, the lack of suitable tools and methods has h ered the progress of this field. Herein, we present a hybrid nanodot strategy, termed AIE-Gd dots, comprising of a fluorogen with aggregation-induced emission (AIE) characteristics as the core to provide bright and stable fluorescence for optical imaging, and gadolinium (Gd) for accurate quantification of vascular leakage via inductively-coupled plasma mass spectrometry (ICP-MS). In this report, we demonstrate that AIE-Gd dots enable direct visualization of brain vascular networks under resting condition, and that they form localized punctate aggregates and accumulate in the brain tissue during experimental cerebral malaria, indicative of hemorrhage and BBB malfunction. With its superior detection sensitivity and multimodality, we hereby propose that AIE-Gd dots can serve as a better alternative to Evans blue for visualization and quantification of changes in brain barrier functions.
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: Wiley
Date: 19-08-2013
Abstract: Ultrabright organic dots with aggregation-induced emission characteristics (AIE dots) are prepared and shown to exhibit a high quantum yield, a, large two-photon absorption cross-section, and low in vivo toxicity. Real-time two-photon intravital blood vascular imaging in various tissues substantiates that the AIE dots are effective probes for in vivo vasculature imaging in a deep and high-contrast manner.
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: American Chemical Society (ACS)
Date: 23-04-2020
Publisher: American Chemical Society (ACS)
Date: 19-06-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7FD90002C
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2JM31368E
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: American Chemical Society (ACS)
Date: 22-04-2020
Publisher: Wiley
Date: 23-12-2016
Location: Singapore
Start Date: 2023
End Date: 12-2025
Amount: $424,000.00
Funder: Australian Research Council
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