ORCID Profile
0000-0002-5373-0811
Current Organisations
KU Leuven
,
University Hospitals Leuven
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Publisher: Springer Science and Business Media LLC
Date: 08-2019
DOI: 10.1038/S41556-019-0360-Z
Abstract: Endometrial disorders represent a major gynaecological burden. Current research models fail to recapitulate the nature and heterogeneity of these diseases, thereby h ering scientific and clinical progress. Here we developed long-term expandable organoids from a broad spectrum of endometrial pathologies. Organoids from endometriosis show disease-associated traits and cancer-linked mutations. Endometrial cancer-derived organoids accurately capture cancer subtypes, replicate the mutational landscape of the tumours and display patient-specific drug responses. Organoids were also established from precancerous pathologies encompassing endometrial hyperplasia and Lynch syndrome, and inherited gene mutations were maintained. Endometrial disease organoids reproduced the original lesion when transplanted in vivo. In summary, we developed multiple organoid models that capture endometrial disease ersity and will provide powerful research models and drug screening and discovery tools.
Publisher: Springer Science and Business Media LLC
Date: 20-03-2014
Publisher: American Chemical Society (ACS)
Date: 05-09-2019
Publisher: Elsevier BV
Date: 03-2018
DOI: 10.1016/J.EJPS.2017.12.008
Abstract: Brain tumor is a lethal, fast growing cancer and a difficult case for treatment. Receptor-mediated endocytosis has been recognized as one of the most effective methods for drug delivery to brain tissue by overcoming obstacles associated with conventional therapeutics. In this work, a targeted theranostic drug delivery system (DDS) was prepared based on gold‑iron oxide nanocomposites (Fe
Publisher: Springer Science and Business Media LLC
Date: 03-2023
Publisher: Elsevier BV
Date: 04-2014
DOI: 10.1016/J.IJBIOMAC.2014.01.006
Abstract: Acetylcholinesterase (AChE) is the enzyme that controls the acetylcholine (ACh) concentrations in cholinergic synaptic clefts by hydrolyzing ACh to choline and acetate. Cholinergic synapses are involved in important functions such as learning, memory and cognition. In this study, we investigated the effects of a wide range of extremely low frequency electromagnetic fields (ELF-EMFs) on synaptic ACh concentrations through AChE enzyme activity assay. Synaptosome suspensions were prepared as a neural terminus from cerebral cortex of sheep brain. Prepared synaptosomes were exposed to ELF-EMFs with frequency ranging from 50 Hz to 230 Hz for duration between 15 and 120 min and flux intensity between 0.1 mT and 1.7 mT. Consequently, AChE activity was measured by Ellman method. Raw data were analyzed by neural network based software, Inform 4.02, to predict AChE activity pattern through nine 3D curves. These curves showed that AChE activity decreases when exposed to ELF-EMFs of 1.2 mT to 1.7 mT intensity and 50 Hz to 90 Hz frequency. Thus, it is proposed that exposure to fields of in this range of frequency-intensity would be effective in clinical treatments of cholinergic disorders to increase synaptic ACh concentration. However, more in vivo experiments are needed to develop this suggested treatment.
Publisher: Informa UK Limited
Date: 23-04-2019
No related grants have been discovered for Carla Tomassetti.