ORCID Profile
0000-0002-6743-751X
Current Organisations
Brigham and Women's Hospital
,
Harvard University
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Publisher: Springer Science and Business Media LLC
Date: 10-2023
Publisher: Springer Science and Business Media LLC
Date: 22-02-2022
DOI: 10.1038/S41467-021-27917-X
Abstract: Human gut microbiome research focuses on populations living in high-income countries and to a lesser extent, non-urban agriculturalist and hunter-gatherer societies. The scarcity of research between these extremes limits our understanding of how the gut microbiota relates to health and disease in the majority of the world’s population. Here, we evaluate gut microbiome composition in transitioning South African populations using short- and long-read sequencing. We analyze stool from adult females living in rural Bushbuckridge ( n = 118) or urban Soweto ( n = 51) and find that these microbiomes are taxonomically intermediate between those of in iduals living in high-income countries and traditional communities. We demonstrate that reference collections are incomplete for characterizing microbiomes of in iduals living outside high-income countries, yielding artificially low beta ersity measurements, and generate complete genomes of undescribed taxa, including Treponema , Lentisphaerae, and Succinatimonas . Our results suggest that the gut microbiome of South Africans does not conform to a simple “western-nonwestern” axis and contains undescribed microbial ersity.
Publisher: Springer Science and Business Media LLC
Date: 17-09-2022
Publisher: Cold Spring Harbor Laboratory
Date: 18-10-2021
Publisher: Wiley
Date: 10-02-2022
DOI: 10.1111/DOM.14655
No related grants have been discovered for Tinashe Chikowore.