ORCID Profile
0000-0001-9412-1433
Current Organisations
Ingham Institute
,
Liverpool Hospital
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Publications
Hidradenitis suppurativa, a review of pathogenesis, associations and management. Part 1.
Publisher: Wiley
Date: 21-01-2018
DOI: 10.1111/AJD.12770
Abstract: Hidradenitis suppurativa is a chronic, painful, autoinflammatory condition resulting in nodules, abscesses and sinus tracts. We present an evidence-based review providing new understanding of the pathogenesis of hidradenitis suppurativa and associated comorbidities. By the nature of their speciality, dermatologists are uniquely positioned to investigate and treat patients with this condition. Data collected from a subspecialty hidradenitis suppurativa clinic (N = 106) and experiences thereof are discussed in this review.
Adopting the orphan: The importance of recognising hidradenitis suppurativa as a systemic auto-inflammatory disease
Publisher: Wiley
Date: 28-01-2016
DOI: 10.1111/AJD.12287
A retrospective cohort study evaluating the accuracy of clinical diagnosis compared with immunofluorescence and electron microscopy in children with inherited epidermolysis bullosa
Publisher: Oxford University Press (OUP)
Date: 25-02-2019
DOI: 10.1111/BJD.17648
Phenotypic heterogeneity implies heterogeneous pathogenic pathways in hidradenitis suppurativa
Publisher: Wiley
Date: 09-03-2015
DOI: 10.1111/EXD.12648
AUSTRALIAN AUTOINFLAMMATORY DISEASES REGISTRY (AADRY): A NATIONAL APPROACH TO THE GENETIC AND IMMUNOLOGICAL EVALUATION OF PATIENTS WITH SUSPECTED AUTOINFLAMMATORY DISEASE
Publisher: Wiley
Date: 09-2016
DOI: 10.1111/IMJ.73_13197
SAPHO syndrome associated with hidradenitis suppurativa and pyoderma gangrenosum successfully treated with adalimumab and methotrexate: a case report and review of the literature
Publisher: Wiley
Date: 07-09-2018
DOI: 10.1111/IJD.13740
Abstract: SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome is a rare inflammatory condition describing the combination of skin, bone, and joint manifestations that has a heterogeneous presentation. We report a case of severe SAPHO syndrome in association with hidradenitis suppurativa and pyoderma gangrenosum in a 27-year-old male. The patient had an initial migratory arthritis affecting the knees, ankles, metacarpophalangeal joints, proximal interphalangeal joints, wrists, shoulder, and lower back, which progressed to a persistent arthritis and swelling at the sternum, shoulders, wrists, hands, feet, and lower back. Radiographic changes were consistent with the diagnosis of SAPHO syndrome. Serum proinflammatory cytokine levels were significantly elevated and improved substantially after 3 months of therapy. Rationale for therapy in this patient was the observation that tumor necrosis alpha antagonists have been successfully used in SAPHO syndrome, and since arthropathy was so prominent in our patient, we elected to use adalimumab combined with methotrexate.
Development and validation of the International Hidradenitis Suppurativa Severity Score System (
IHS
4), a novel dynamic scoring system to assess
HS
Publisher: Oxford University Press (OUP)
Date: 30-10-2017
DOI: 10.1111/BJD.15748
Abstract: A validated tool for the dynamic severity assessment of hidradenitis suppurativa/acne inversa (HS) is lacking. To develop and validate a novel dynamic scoring system to assess the severity of HS. A Delphi voting procedure was conducted among the members of the European Hidradenitis Suppurativa Foundation (EHSF) to achieve consensus towards an initial HS Severity Score System (HS4). Strengths and weaknesses of HS4 were examined by a multicentre prospective study. Multivariate logistic regression, discriminant analysis and receiver operating characteristic curves, as well as examination for correlation (Spearman's rho) and agreement (Cohen's kappa) with existing scores, were engaged to recognize the variables for a new International HS4 (IHS4) that was established by a second Delphi round. Consensus HS4 was based on number of skin lesions, number of skin areas involved and Dermatology Life Quality Index (DLQI), and was evaluated by a s le of 236 patients from 11 centres. Subsequently, a multivariate regression model calculated adjusted odds ratios for several clinical signs. Nodules, abscesses and draining tunnels resulted as the scoring variables. Three candidate scores were presented to the second Delphi round. The resulting IHS4 score is arrived at by the number of nodules (multiplied by 1) plus the number of abscesses (multiplied by 2) plus the number of draining tunnels (multiplied by 4). A total score of 3 or less signifies mild, 4-10 signifies moderate and 11 or higher signifies severe disease. Cohen's kappa was fair (κ = 0·32) compared with Hurley classification, and moderate (κ = 0·49) compared with Expert Opinion. Correlation was good (ρ > 0·6) with Hurley classification, Expert Opinion, Physician's Global Assessment and Modified Sartorius score, and moderate for DLQI (ρ = 0·36). The novel IHS4 is a validated tool to dynamically assess HS severity and can be used both in real-life and the clinical trials setting.
Drug-associated hidradenitis suppurativa: A systematic review of case reports.
Publisher: Elsevier BV
Date: 2018
Pharmaceutical Benefits Scheme listing of adalimumab for hidradenitis suppurativa: Is hidradenitis suppurativa a life-changing drug or does lifestyle change the drug?
Publisher: Wiley
Date: 29-12-2017
DOI: 10.1111/AJD.12767
A systematic review and critical evaluation of reported pathogenic sequence variants in hidradenitis suppurativa
Publisher: Oxford University Press (OUP)
Date: 20-09-2017
DOI: 10.1111/BJD.15441
Abstract: Hidradenitis suppurativa (HS) is a severe chronic inflammatory disorder characterized by recurrent painful deep-seated nodules with a predilection to the apocrine-bearing areas of skin. A minority of cases of HS are due to mutations in the γ-secretase complex. Contention exists surrounding the pathogenicity of sequence variants and their effects upon Notch signalling. This systematic review was registered with PROSPERO (CRD42016041425) and was conducted in line with the PRISMA statement. Eligibility criteria for this review included published case reports, case series and reviews that identified sequence variants or protein or functional studies from patients with HS. Sixty-two articles were identified reporting a total of 41 sequence variants - heterozygous missense (nine), splice site (nine), insertion resulting in frameshift (one), premature termination codon (19) and promoter region PSTPIP1 (three) - with 18 associated protein or functional studies. The American College of Medical Genetics and Genomics standards and guidelines on the interpretation of sequence variants were applied to each identified variant to assess evidence for pathogenicity. Twenty-three variants were assessed as likely pathogenic, 17 of uncertain significance and one benign. The large number of variants of 'uncertain significance' is largely due to the variable number of functional studies. Four studies used Notch as a proxy for γ-secretase function, with conclusions of nonpathogenicity based on the assumption of Notch signalling as the sole pathogenic process. The role of Notch-independent signalling mechanisms requires further research. Limitations to this study include identification of variants of Mendelian inheritance and not complex polygenic traits.
Staphylococcus lugdunensis: case report and discussion
Publisher: Wiley
Date: 11-2014
DOI: 10.1111/AJD.12209
Hidradenitis suppurativa: A neglected disease in Indigenous Australians
Publisher: Wiley
Date: 09-08-2018
DOI: 10.1111/AJD.12697
Abstract: We report the first case series of hidradenitis suppurativa in patients of Indigenous Australian heritage. The incidence and ethnicity of populations affected by this condition are not known. The high comorbid disease burden and socioeconomic disadvantage that is well recognised in the Indigenous Australian population poses significant challenges to therapeutic outcomes.
Hidradenitis suppurativa, a review of pathogenesis, associations and management. Part 2
Publisher: Wiley
Date: 23-01-2018
DOI: 10.1111/AJD.12766
Abstract: Hidradenitis suppurativa is a chronic, painful, autoinflammatory condition resulting in nodules, abscesses and sinus tracts. We present an evidence-based review providing new understanding of the pathogenesis of hidradenitis suppurativa and associated comorbidities. By the nature of their speciality, dermatologists are uniquely positioned to investigate and treat patients.
Related Organisations
Related Funding Activities
No related grants have been discovered for Dunja Vekic.