ORCID Profile
0000-0003-2841-7580
Current Organisations
Newcastle University
,
Monash University
,
Monash University Malaysia
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In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Pattern Recognition and Data Mining | Psychology | Computer-Human Interaction | Developmental Psychology and Ageing
Expanding Knowledge in Psychology and Cognitive Sciences | Expanding Knowledge in the Medical and Health Sciences | Expanding Knowledge in Technology |
Publisher: ACM
Date: 24-06-2013
Publisher: Springer Berlin Heidelberg
Date: 2007
Publisher: ACM
Date: 11-06-2012
Publisher: Elsevier BV
Date: 04-2013
Publisher: Elsevier BV
Date: 03-1988
DOI: 10.1016/0021-9150(88)90104-9
Abstract: These studies examine the effects of a hypercholesterolemic diet (with butter and cholesterol added), or a hypertriglyceridemic diet (30% sucrose (w/v) in drinking water), on murine plasma lipids and lipoproteins prepared either by sequential ultracentrifugation or gel exclusion chromatography. The hypercholesterolemic diet increased plasma cholesterol (186%), particularly that associated with very low (VLDL) and low (LDL) density lipoproteins. In addition, the cholesterol/triglyceride ratio in the VLDL fraction rose significantly from 0.10 to 4.0. The hypertriglyceridemic diet raised markedly plasma triglyceride levels (46%) by expanding the circulating VLDL pool (+39%). These dietary modifications were used to provide a model for the examination of 3 classical hypolipidemic drugs (fenofibrate, gemfibrozil and nicotinic acid). In animals receiving the standard diet, fenofibrate, gemfibrozil and nicotinic acid decreased the triglyceride (TG) level (-28%, -31%, and -38%) by lowering VLDL-TG (-37%, -42%, and -49%), fenofibrate and gemfibrozil increased HDL-cholesterol by 18% and 31%, respectively. In animals receiving the hypercholesterolemic diet fenofibrate lowered the total plasma cholesterol level by 40%, at the same time increasing HDL-cholesterol by 23%. In animals fed sucrose, on the other hand, fenofibrate (100 mg/kg per day) and nicotinic acid (900 and 600 mg/kg per day) reduced plasma triglyceride levels (-20%, -40% and -33%), and nicotinic acid (900 mg/kg per day) decreased VLDL-TG by 58%. These results are in good agreement with clinical data from studies in man and suggest that this animal model may provide a useful and rapid screening system for testing new lipid lowering drugs.
Publisher: Cambridge University Press (CUP)
Date: 26-09-2016
DOI: 10.1017/S0033291716002166
Abstract: Late-life depression (LLD) is associated with a decline in physical activity. Typically this is assessed by self-report questionnaires and, more recently, with actigraphy. We sought to explore the utility of a bespoke activity monitor to characterize activity profiles in LLD more precisely. The activity monitor was worn for 7 days by 29 adults with LLD and 30 healthy controls. Subjects underwent neuropsychological assessment and quality of life (QoL) (36-item Short-Form Health Survey) and activities of daily living (ADL) scales (Instrumental Activities of Daily Living Scale) were administered. Physical activity was significantly reduced in LLD compared with controls ( t = 3.63, p 0.001), primarily in the morning. LLD subjects showed slower fine motor movements ( t = 3.49, p 0.001). In LLD patients, activity reductions were related to reduced ADL ( r = 0.61, p 0.001), lower QoL ( r = 0.65, p 0.001), associative learning ( r = 0.40, p = 0.036), and higher Montgomery–Åsberg Depression Rating Scale score ( r = −0.37, p 0.05). Patients with LLD had a significant reduction in general physical activity compared with healthy controls. Assessment of specific activity parameters further revealed the correlates of impairments associated with LLD. Our study suggests that novel wearable technology has the potential to provide an objective way of monitoring real-world function.
Publisher: MIT Press - Journals
Date: 2018
DOI: 10.1162/DESI_A_00479
Abstract: This article presents a number of perspectives on mortality in light of both Victorian mourning and memento mori jewelry and bereavement therapy and grieving. Both help to reveal valuable qualities for digital design. The article then illustrates how these qualities influenced the design of four digital lockets, examining how both Victorian and modern practices relate to mortality, mourning, grief, and death, and exploring possibilities for digital design. Finally, ongoingness—by reference to the work of artist Moira Ricci—is explained as both a theoretical construct and a resource for design practice. Central in the proposal is the notion that, rather than being distanced or detached from the deceased (as has been the predominant grieving therapy approach of modernity), the bereaved can continue to have an active and growing relationship with them.
Publisher: ACM
Date: 07-05-2011
Publisher: Wiley
Date: 21-11-2008
Publisher: ACM
Date: 07-05-2016
Publisher: Elsevier BV
Date: 07-2003
Abstract: Remedies for coughs and colds often contain both an indirect sympathomimetic agent plus another drug (anti-inflammatory, analgesic or antibiotic, etc.). In France, oral sympathomimetics are available over the counter, and preparations for topical use (nasal sprays or drops) require a medical prescription. Using the French Pharmacovigilance database, we performed a retrospective study to identify cardiovascular and neurological adverse drug reactions (ADRs) associated with the use of nasal decongestants containing a sympathomimetic agent. Of a total of 165 ADRs. 15 were strokes or cerebral haemorrhages. We also found the following: 67 cases of arterial hypertension, 33 of convulsions, 28 of headaches and 24 of vasomotor symptoms involving the extremities. In most of these cases, misuse or a predisposing factor was found (such as a history of arterial hypertension or headache, the combination of two decongestants, long-term use, etc.). The incidence of cardiovascular or neurological ADRs with cold remedies seems 'very rare' but some of these reactions, mainly stroke, are 'serious'. However, there is no available clinical evidence showing the benefit of such agents after repeated use over several days. Since most of the nasal decongestants are freely available without prescription, drug information is needed to advise prescribers and also patients about risk of 'serious' ADRs with these drugs.
Publisher: Informa UK Limited
Date: 11-10-2017
Publisher: Springer Science and Business Media LLC
Date: 12-04-2003
DOI: 10.1007/S00259-003-1137-X
Abstract: These guidelines, which summarise the views of the Paediatric Committee of the European Association of Nuclear Medicine, provide a framework which may prove helpful to nuclear medicine teams in daily practice. They contain information on the indications, acquisition, processing and interpretation of direct radioisotope cystography in children. The guidelines should be taken in the context of "good practice" and any local/national rules which apply to nuclear medicine examinations.
Publisher: ACM
Date: 02-05-2017
Publisher: Walter de Gruyter GmbH
Date: 05-2009
Abstract: The declarative design of graphics lies at the core of the Smart Graphics research agenda. For 3D graphics the number of lights included, and the properties of these lights, has an enormous impact on what a viewer can judge about the content (the objects), properties (the geometric characteristics and spatial relations of the objects) and other aesthetic qualities of a scene. The traditional approach to lighting design for image synthesis is based on manual design methods, whereby users interactively specify values of lighting parameters, render the scene, and modify the lighting parameters until the desired visual properties of the scene are achieved. Non-expert users encounter a number of difficulties in selecting the appropriate lighting parameters, as the process requires both a subtle technical and aesthetic understanding of lighting in computer graphics. We review range of “smart” lighting design and steady slow convergence on ideal lighting approaches which optimise the lighting configuration for a scene with respect to a set of absolute perceptual metrics. More recently perceptual approaches have been combined with aspects of exemplar driven approaches to yield “lighting-by-ex le” techniques that can replicate the lighting of existing static 2D images and 3D scenes.
Publisher: Elsevier BV
Date: 03-2012
DOI: 10.1016/J.EJCA.2011.12.023
Abstract: To investigate the dose-response relationship and pain-relieving effect of radium-223, a highly bone-targeted alpha-pharmaceutical. One hundred patients with castration-resistant prostate cancer (CRPC) and painful bone metastases were randomized to a single intravenous dose of 5, 25, 50 or 100 k Bq/kg radium-223. The primary end-point was pain index (visual analogue scale [VAS] and analgesic use), also used to classify patients as responders or non-responders. A significant dose response for pain index was seen at week 2 (P = .035). At week 8 there were 40%, 63%, 56% and 71% pain responders (reduced pain and stable analgesic consumption) in the 5, 25, 50 and 100 k Bq/kg groups, respectively. On the daily VAS, at week 8, pain decreased by a mean of -30, -31, -27 and -28 mm, respectively (P = .008, P = .0005, P = .002, and P < . 0001) in these responders (post-hoc analysis). There was also a significant improvement in the brief pain inventory functional index for all dose-groups (P = .04, .01, .002 and .02, Wilcoxon signed rank test). Furthermore, a decrease in bone alkaline phosphatase in the highest dose-group was demonstrated (P = .0067). All doses were safe and well tolerated. Pain response was seen in up to 71% of the patients with a dose response observed 2 weeks after administration. The highly tolerable side-effect profile of radium-223 previously reported was confirmed.
Publisher: Elsevier BV
Date: 05-2011
DOI: 10.1016/J.ANNDER.2011.02.023
Abstract: PET/CT has proven extremely useful in the management of melanoma patients, with great sensitivity (Se), but it tends to give false-positive results. Whole-body MRI (wb-MRI) is a new method that has made considerable progress. The aim of this study was to assess the Se and specificity (Sp) of wb-MRI with a diffusion sequence for detecting melanoma metastasis compared to PET/CT. This was a prospective study, including patients at any AJCC (American Joint Committee on Cancer) stage of melanoma. PET/CT, wb-MRI and CT, including the brain, were performed on the same day. For each of the three exams, the number of lesions per patient was counted. The treatments proposed by the doctor immediately after PET/CT and then MRI were compared. Forty patients were included and a total of 72 metastases were noted. CT detected 53 of these metastases (Se 80%, Sp 95%), while PET/CT detected 53 metastases, with four false-positive (Se 74%, Sp 89%) and Wb-MRI detected 59, with two false-positive (Se 83%, Sp 96%). The sensitivity of MRI was distinctly superior to PET/CT for both hepatic and pulmonary lesions. The treatment proposed after PET/CT and MRI differed in three cases: one patient was falsely reclassified by MRI (AJCC IV instead of IIB) while two others were falsely reclassified by PET/CT (AJCC IV instead of IB and IIIC). Exclusively whole-body scan influenced the treatment of four patients (10%). Wb-MRI with diffusion sequence, which is less costly than PET/CT and is also non-radioactive, could play an important role in the detection of metastases in melanoma patients.
Publisher: Springer Science and Business Media LLC
Date: 2001
Publisher: Elsevier BV
Date: 09-2011
Publisher: Cambridge University Press (CUP)
Date: 06-2006
Publisher: Springer International Publishing
Date: 2015
Publisher: Springer International Publishing
Date: 2015
Publisher: Elsevier BV
Date: 10-1996
Publisher: Springer Science and Business Media LLC
Date: 14-04-2014
Abstract: Computer based gaming systems, such as the Microsoft Kinect (Kinect), can facilitate complex task practice, enhance sensory feedback and action observation in novel, relevant and motivating modes of exercise which can be difficult to achieve with standard physiotherapy for people with Parkinson’s disease (PD). However, there is a current need for safe, feasible and effective exercise games that are appropriate for PD rehabilitation. The aims of this study were to i) develop a computer game to rehabilitate dynamic postural control for people with PD using the Kinect and ii) pilot test the game’s safety and feasibility in a group of people with PD. A rehabilitation game aimed at training dynamic postural control was developed through an iterative process with input from a design workshop of people with PD. The game trains dynamic postural control through multi-directional reaching and stepping tasks, with increasing complexity across 12 levels of difficulty. Nine people with PD pilot tested the game for one session. Participant feedback to identify issues relating to safety and feasibility were collected using semi-structured interviews. Participants reported that they felt safe whilst playing the game. In addition, there were no adverse events whilst playing. In general, the participants stated that they enjoyed the game and seven of the nine participants said they could imagine themselves using the game at home, especially if they felt it would improve their balance. The Flow State Scale indicated participants were immersed in the gameplay and enjoyed the experience. However, some participants reported that they found it difficult to discriminate between different types and orientations of visual objects in the game and some also had difficulty with the stepping tasks, especially when performed at the same time as the reaching tasks. Computer-based rehabilitation games using the Kinect are safe and feasible for people with PD although intervention trials are needed to test their safety, feasibility and efficacy in the home.
Publisher: JMIR Publications Inc.
Date: 16-01-2019
Abstract: nder-reporting because of the limitations of human memory is one of the key challenges in dietary assessment surveys that use the multiple-pass 24-hour recall. Research indicates that shortening a retention interval (ie, the time between the eating event and recall) reduces the burden on memory and may increase the accuracy of the assessment. his study aimed to explore the accuracy and acceptability of Web-based dietary assessment surveys based on a progressive recall, where a respondent is asked to record multiple recalls throughout a 24-hour period using the multiple-pass protocol and portion size estimation methods of the 24-hour recall. he experiment was conducted with a dietary assessment system, Intake24, that typically implements the multiple-pass 24-hour recall method where respondents record all meals they had for the previous day on a single occasion. We modified the system to allow respondents to add multiple recalls throughout the day using the multiple-pass protocol and portion size estimation methods of the 24-hour recall (progressive recall). We conducted a dietary assessment survey with 33 participants, where they were asked to record dietary intake using both 24-hour and progressive recall methods for weekdays only. We compared mean retention intervals (ie, the time between eating event and recall) for the 2 methods. To examine accuracy, we compared mean energy estimates and the mean number of reported foods. Of these participants, 23 were interviewed to examine the acceptability of the progressive recall. etention intervals were found to be, on average, 15.2 hours (SD 7.8) shorter during progressive recalls than those during 24-hour recalls. We found that the mean number of foods reported for evening meals for progressive recalls (5.2 foods) was significantly higher ( i P /i =.001) than that for 24-hour recalls (4.2 foods). The number of foods and the amount of energy reported for other meals remained similar across the 2 methods. In interviews, 65% (15/23) of participants said that the 24-hour recall is more convenient in terms of fitting in with their daily lifestyles, and 65% (15/23) of respondents indicated that they remembered meal content and portion sizes better with the progressive recall. he analysis of interviews and data from our study indicate that progressive recalls provide minor improvements to the accuracy of dietary assessment in Intake24. Additional work is needed to improve the acceptability of progressive recalls in this system.
Publisher: ACM
Date: 10-06-2017
Publisher: Springer Netherlands
Date: 1998
Publisher: Elsevier BV
Date: 07-1999
DOI: 10.1016/S0735-1097(99)00156-4
Abstract: The purpose of this study was to determine whether antianginal medications modify the prognostic significance of exercise single photon emission computed tomography (SPECT) ischemia. Antianginal medications (especially beta-adrenergic blocking agents) limit exercise SPECT ischemia, but it is not known whether such medications also modify the prognostic effect of exercise SPECT ischemia. We included 352 patients with coronary heart disease, who had exercise Tl-201 SPECT and coronary angiography, and who were initially treated medically. Survival Cox models were applied in patients for whom classes of antianginal medications taken at exercise SPECT were the same as those prescribed for follow-up (GI n = 136), and in patients for whom new classes of antianginal medications, including beta-blockers (GII n = 79) or not including beta-blockers (GIII n = 113), were added for follow-up. During a mean 5.3+/-1.6 years of follow-up, 45 patients had cardiac death or myocardial infarction. Variables reflecting necrosis (irreversible defect extent, left ventricular ejection fraction) and those from coronary angiography provided equivalent prognostic information in the three groups. In contrast, the SPECT variable reflecting ischemia (reversible defect extent), which provided comparable prognostic information in GI (p = 0.005) and GIII (p = 0.004), lost its prognostic significance (p = 0.54) in GII, and was associated with a lower relative risk in GII than in GI or GIII (both p < 0.05). In patients with coronary heart disease, the introduction of antianginal medications, when including beta-blockers, appears to have a favorable effect on the deleterious prognostic effect of exercise ischemia.
Publisher: Elsevier BV
Date: 08-2012
Publisher: ACM
Date: 02-05-2017
Publisher: ACM
Date: 21-04-2018
Publisher: Elsevier BV
Date: 11-2014
Publisher: SAGE Publications
Date: 03-1999
DOI: 10.1345/APH.18162
Publisher: Cambridge University Press (CUP)
Date: 2016
Publisher: JMIR Publications Inc.
Date: 05-08-2022
DOI: 10.2196/39280
Abstract: Improving preconception health can benefit all women, their children, and their families regardless of their in idual pregnancy intentions. Rapidly increasing access to information technology and online engagement have created opportunities to use digital health resources to engage with preconception women regarding lifestyle behaviors. This study explores how preconception women engage with digital health resources and online platforms to inform the design and development of a digital health resource to support women to make positive behavior change for their preconception health. This codesign research followed the Double Diamond process, which focuses on contextualization and explorative processes in phase 1 and ideation and development processes in phase 2. Phase 1 is reported on in this study and was undertaken via a series of 1-on-1 in-depth interviews with female participants (N=12) aged 18-45 years over 3 months. Interviews were designed to explore participants’ lived experiences in relation to their health and desired supports for healthy lifestyle behaviors. The first interview focused on participants’ perceptions of health and health behaviors, the second interview focused on social connections for health, and the third interview focused on digital health information and supports. Conversations from the first interview informed the development of the second interview, and conversations from the second interview informed the development of the third interview. Community advisors (N=8) met to provide feedback and advice to the researchers throughout the interview process. Qualitative analyses of transcripts from interviews were undertaken by 2 researchers before a deductive process identified themes mapped to the capability, opportunity, motivation, and behavior (COM-B) framework. In total, 9 themes and 8 subthemes were identified from 124 codes. In relation to digital health resources, specifically, participants were already engaging with a range of digital health resources and had high expectations of these. Digital health resources needed to be easy to access, make women’s busy lives easier, be evidence based, and be reputable. Social connectedness was also highly important to our participants, with information and advice from peers with similar experiences being preferred over yet more online health information. Online communities facilitated these social interactions. Participants were open to the idea of chatbots and virtual assistants but acknowledged that they would not replace authentic social interactions. Codesigned digital health resources should be evidence based, reputable, and easy to access. Social connections were considered highly important to women, and designers of digital health resources should consider how they can increase opportunities for women to connect and learn from each other to promote health behaviors.
Publisher: Springer Science and Business Media LLC
Date: 26-04-1999
Abstract: beta-Methyl-substituted free fatty acids (FFAs) have been developed for myocardial single-photon emission tomography (SPET) imaging, but little is known about their kinetics in ischaemic conditions. The aim of this study was to determine the changes in the myocardial kinetics of a beta-methyl-branched FFA, [123I]16-iodo-3-methyl-hexadecanoic acid (MIHA), under ischaemic conditions. The kinetics of MIHA were analysed: (a) using a blood-perfused isolated heart model subjected to moderate ischaemia (50% flow reduction) and (b) in patients who had an exercise thallium-201 SPET defect corresponding to either necrotic (n = 13) or chronically ischaemic and viable (n = 15) myocardium, and who underwent two consecutive SPET studies after MIHA injection. In animals, the myocardial early retention fraction of MIHA, but not its clearance rate, was dependent on coronary flow, the early retention fraction being higher in ischaemic than in normoxic conditions (0.24 +/- 0.10 vs 0.14 +/- 0.04, P = 0.004). In the patient SPET studies, the uptake of MIHA calculated in ischaemic and viable areas (G1: 74% +/- 9% of maximal left ventricular value) was different from that calculated in necrotic (G2: 59% +/- 7%, P < 0.001) or normal (G3: 88 +/- 6%, P < 0.001) areas. By contrast, MIHA-clearance calculated between the two consecutive SPET studies was not different in G1, G2 and G3. Unlike in the case of other FFAs, the myocardial clearance of MIHA is not decreased by ischaemia. However, the early retention of MIHA is increased in the case of a moderate reduction in coronary flow, a property which might help in the detection of viability in chronically ischaemic myocardium.
Publisher: Public Library of Science (PLoS)
Date: 07-05-2019
Publisher: ACM
Date: 26-04-2014
Publisher: Springer Science and Business Media LLC
Date: 22-02-2014
Publisher: Elsevier BV
Date: 06-2011
Publisher: ACM
Date: 05-05-2012
Publisher: ACM
Date: 04-04-2009
Publisher: Springer Berlin Heidelberg
Date: 2009
Publisher: Elsevier BV
Date: 07-2011
Publisher: Springer Berlin Heidelberg
Date: 2008
Publisher: Informa UK Limited
Date: 04-1994
Abstract: Src homology 2 (SH2) domains provide specificity to intracellular signaling by binding to specific phosphotyrosine (phospho-Tyr)-containing sequences. We recently developed a technique using a degenerate phosphopeptide library to predict the specificity of in idual SH2 domains (src family members, Abl, Nck, Sem5, phospholipase C-gamma, p85 subunit of phosphatidylinositol-3-kinase, and SHPTP2 (Z. Songyang, S. E. Shoelson, M. Chaudhuri, G. Gish, T. Pawson, W. G. Haser, F. King, T. Roberts, S. Ratnofsky, R. J. Lechleider, B. G. Neel, R. B. Birge, J. E. Fajardo, M. M. Chou, H. Hanafusa, B. Schaffhausen, and L. C. Cantley, Cell 72:767-778, 1993). We report here the optimal recognition motifs for SH2 domains from GRB-2, Drk, Csk, Vav, fps/fes, SHC, Syk (carboxy-terminal SH2), 3BP2, and HCP (amino-terminal SH2 domain, also called PTP1C and SHPTP1). As predicted, SH2 domains from proteins that fall into group I on the basis of a Phe or Tyr at the beta D5 position (GRB-2, 3BP2, Csk, fps/fes, Syk C-terminal SH2) select phosphopeptides with the general motif phospho-Tyr-hydrophilic (residue)-hydrophilic (residue)-hydrophobic (residue). The SH2 domains of SHC and HCP (group III proteins with Ile, Leu, of Cys at the beta D5 position) selected the general motif phospho-Tyr-hydrophobic-Xxx-hydrophobic, also as predicted. Vav, which has a Thr at the beta D5 position, selected phospho-Tyr-Met-Glu-Pro as the optimal motif. Each SH2 domain selected a unique optimal motif distinct from motifs previously determined for other SH2 domains. These motifs are used to predict potential sites in signaling proteins for interaction with specific SH2 domain-containing proteins. The Syk SH2 domain is predicted to bind to Tyr-hydrophilic-hydrophilic-Leu/Ile motifs like those repeated at 10-residue intervals in T- and B-cell receptor-associated proteins. SHC is predicted to bind to a subgroup og these same motifs. A structural basis for the association of Csk with Src family members is also suggested from these studies.
Publisher: Springer Science and Business Media LLC
Date: 2002
Publisher: Springer Science and Business Media LLC
Date: 18-03-2011
DOI: 10.3758/S13428-011-0074-Z
Abstract: The n-back task is commonly used to load working memory (WM) in dual-task and neuroimaging experiments. However, it typically involves visual presentation and buttonpress responses, making it unsuitable for combination with primary tasks that involve vision and action, such as sequential object use and other tasks of daily living. The N-backer software presented here will automatically present and score auditory-verbal n-back sequences utilising the standard speech synthesis and recognition facilities that come with Microsoft Windows. Data are presented from an experiment in which 12 student participants carried out three tasks from the Naturalistic Action Test (NAT) while their attention was ided between the primary task and a continuous auditory-verbal 2-back secondary task. The participants' 2-back performance was scored in two ways: by hand, from video recordings, and automatically, using the software, allowing us to evaluate the accuracy of N-backer. There was an extremely high correlation between these scores (.933). The videos were also used to obtain a comprehensive error score for the NAT. Significantly more errors were made in the more complex NAT tasks when participants were 2-backing, as compared with when they were not, showing that the auditory-verbal n-back task can be used to disrupt sequential object use. This dual-task method may simulate the attentional deficits of patients with brain injury, providing insights into the difficulties they face in tasks of daily living.
Publisher: Elsevier BV
Date: 09-2000
Abstract: Diagnosis of arterial prosthetic infection is often difficult to confirm. Several cases of lower extremity hypertrophic osteoarthropathy (HOA) have been associated with arterial prosthetic infection. The presence of bone and joint abnormalities could constitute an early sign of HOA. The purpose of this prospective study was to determine the diagnostic value of routine bone scintiscan in patients hospitalized for suspected arterial prosthesis infection. Between December 1995 and May 1997, 17 patients with suspected infection were admitted to our institution. All underwent bone scintiscan before surgical treatment. Presence or absence of infection was defined according to the criteria proposed by Yeager. During the same period, bone scintiscan was performed in a control group of 8 patients with arterial prostheses but no clinical or laboratory signs of infection. Scintiscans were studied to detect bone and joint abnormalities distal to the arterial prosthesis. The results of this preliminary study indicate that routine bone scintiscan can assist definitive diagnosis in patients with suspected arterial prosthesis infection. Demonstration of bone and joint abnormalities distal to a prosthesis appears to be a fairly sensitive and highly specific sign of infection.
Publisher: Springer Science and Business Media LLC
Date: 09-2001
Publisher: Association for Computing Machinery (ACM)
Date: 17-02-2015
DOI: 10.1145/2696867
Abstract: Ageing has become a significant area of interest in Human-Computer Interaction (HCI) in recent years. In this article we provide a critical analysis of 30 years of ageing research published across the ACM Special Interest Group on Computer-Human Interaction (SIGCHI) community. Discourse analysis of the content of 644 archival papers highlights how ageing is typically framed as a “problem” that can be managed by technology. We highlight how ageing is typically defined through an emphasis on the economic and societal impact of health and care needs of older people, concerns around socialisation as people age, and declines in abilities and associated reductions in performance when using technology. We draw from research within the fields of social and critical gerontology to highlight how these discourses in SIGCHI literature represent common stereotypes around old age that have also prevailed in the wider literature in gerontology. We conclude by proposing strategies for future research at the intersection of ageing and HCI.
Publisher: Association for Computing Machinery (ACM)
Date: 11-09-2023
DOI: 10.1145/3604255
Publisher: ACM
Date: 26-06-2017
Publisher: ACM
Date: 07-05-2011
Publisher: IEEE
Date: 1993
Publisher: BCS Learning & Development
Date: 2018
Publisher: Springer Netherlands
Date: 1996
Publisher: Atlantis Press
Date: 2011
Publisher: Association for Computing Machinery (ACM)
Date: 16-03-2016
Abstract: Human activity recognition (HAR), i.e., the automated detection and classification of specific activities that a person pursues, is one of the core concerns of mobile and ubiquitous computing. Multimodal sensing facilities of modern mobile devices allow for detailed capture of contextual information, most importantly movement data recorded with inertial measurement units that are now standard in most mobile devices. The majority of HAR applications aim at automatically documenting when something of interest has happened and what that was. For ex le, the popular moves app on iOS and Android devices "automatically records any walking, cycling, and running [a user does]" [7] and as such automatically generates a life log for those interested in their daily movement patterns. Beyond the mere recognition of certain activities of interest, few applications currently go a step further and analyze the quality of a person's activities, i.e., how (well) their activities were performed, which directly corresponds to a person's abilities or skills .
Publisher: Elsevier BV
Date: 11-1988
DOI: 10.1016/0021-9150(88)90186-4
Abstract: The short term effects of fenofibrate (150 mg/kg per day), administered by gavage, on lipoprotein and fatty acid distribution have been investigated in an hypertriglyceridemic model, the Zucker rat. Lean rats were compared to control obese and treated obese rats, and control obese animals to treated obese littermates. Classically, plasma cholesterol and triacylglycerol increased by 1.8- and 7.9-fold, respectively, in control obese versus lean rats. Treatment of the Zucker obese rats with fenofibrate reduced their plasma cholesterol by 10% and raised triacylglycerol by 47% (P less than 0.001) in comparison to untreated control obese rats. These effects were accompanied by a change in the composition of all plasma lipoproteins. The cholesterol/triacylglycerol ratio in VLDL rose by 32% while that in LDL and HDL fell by 43 and 47%, respectively. Drug therapy altered the fatty acid profile in both plasma and liver the percentage of polyunsaturated fatty acids fell while monounsaturated fatty acids increased. The increased proportion of monounsaturated fatty acids in plasma suggests that the fatty acid composition of circulating lipoproteins is modified, particularly in VLDL. This, in association with the altered lipid distribution in VLDL may reflect an abnormal metabolism of this lipoprotein. In view of these abnormalities, we conclude that this rat is not an appropriate model for the short-term study of clofibrate analogues.
Publisher: ACM
Date: 16-12-2009
Publisher: Association for Computational Linguistics
Date: 1994
Publisher: Mary Ann Liebert Inc
Date: 1993
Abstract: An unusual osteogenic anaplastic carcinoma of the thyroid developed in a 68-year-old man and showed follicular and osteosarcomatous components. Seven months after surgery and 70 mCi 131I treatment, a local tumor recurrence was found and showed an intense uptake of 99mTc-MDP on the bone scan. After a second operation, pathologic and immunostaining analysis revealed no more thyroid carcinoma but only osteosarcomatous cells. Chemotherapy was ineffective and the patient died with diffuse pulmonary metastases 26 months after the diagnosis. The importance of osteogenic sarcomatous differentiation is proven by the bone scan. Osteosarcoma of the thyroid is a rare but well known tumor. Usually these tumors do not contain any cells originating from the thyroid epithelium and only comprise sarcomatous components. Ten cases of undifferentiated carcinoma of thyroid origin with osteogenic component have been reported. These tumors have been recently included in undifferentiated carcinomas in the second edition of the WHO classification. The evolution and pathologic findings favor the hypothesis of a transdifferentiation of the thyroid cell into osteogenic cells.
Publisher: SPIE
Date: 04-07-2000
DOI: 10.1117/12.390556
Publisher: International World Wide Web Conferences Steering Committee
Date: 03-04-2017
Publisher: ACM
Date: 25-02-2017
Publisher: Elsevier BV
Date: 11-1997
DOI: 10.1016/S0735-1097(97)00292-1
Abstract: We compared the ability of rest single-photon emission computed tomography (SPECT) with [123I]-16-iodo-3-methylhexadecanoic acid (MIHA) and the thallium-201 (Tl-201) rest-reinjection technique to detect myocardial viability after infarction. After myocardial infarction, MIHA frequently shows increased uptake in the areas with exercise Tl-201 defects (mismatch), even in patients with an irreversible Tl-201 reinjection defect. Whether such increased uptake is indicative of ischemic but viable myocardium is not known. We studied 38 patients who 1) underwent exercise SPECT Tl-201 with rest-reinjection and rest SPECT with MIHA before undergoing percutaneous transluminal coronary angioplasty (PTCA) of an infarct-related coronary artery, and 2) were found to have successful revascularization at follow-up angiography. The relation between SPECT results before PTCA and subsequent improvement in left ventricular wall motion was assessed. A mismatch was evident before PTCA in 51 of 76 infarct-related segments and correlated with subsequent improvement in wall motion (overall accuracy 71%), even for the 27 segments whose exercise defects remained irreversible after Tl-201 reinjection (overall accuracy 81%). The finding of a mismatch clearly enhanced the results provided by the finding of > or = 50% Tl-201 uptake as determined at redistribution (p < 0.05), but not as determined at reinjection, although there was a trend toward a better specificity for the findings of a mismatch. MIHA is an efficient marker of viability inside exercise-underperfused areas after infarction, even in patients with irreversible Tl-201 reinjection defects. Assessment by conventional SPECT of a mismatch between results obtained with a metabolic tracer (MIHA) and a flow tracer analyzed at exercise (Tl-201) as a marker of myocardial viability is a promising area of research.
Publisher: International Society for Horticultural Science (ISHS)
Date: 07-2012
Publisher: ACM
Date: 26-04-2014
Publisher: SciTePress - Science and and Technology Publications
Date: 2008
Publisher: Informa UK Limited
Date: 1994
Publisher: Elsevier BV
Date: 2019
Publisher: IEEE
Date: 1992
Publisher: IGI Global
Date: 2013
DOI: 10.4018/978-1-4666-1933-3.CH013
Abstract: In this case study, the authors revisit the benefits of reflection for learning and classify three different types of reflection support as evident in the pedagogy literature: post-activity, inter-activity and part-of-activity. They present their design of a collaborative learning application (Digital Mysteries) as implemented on the emerging digital tabletop technology. The design of Digital Mysteries aims at demonstrating the potential of technology for providing support for all the identified types of reflection. The application was evaluated through 12 trials with 6 groups of students 11-14 years old in a school environment. Two of the six groups carried out repeated trials with the goal of evaluating benefits from repeated use and to overcome effects resulting from the novelty of the technology. The trials showed clear evidence of reflective interactions, caused by the application’s design, which positively affected subsequent trials. The authors conclude with a number of generalized recommendations for designers of collaborative learning environments.
Publisher: Elsevier BV
Date: 1994
Publisher: SAGE Publications
Date: 02-2008
Abstract: The authors introduce the notion of a crossmodal display as a proposal for enhancing the privacy of public information displays. The selection of appropriate display technology and interaction techniques relies on an understanding of the public—private nature of information and the spaces from which it is accessed. The crossmodal display framework supports multiple users simultaneously accessing information that contains public and personal elements. Crossmodal displays are multiuser interfaces that facilitate the efficient public access of personalized information, while maintaining the anonymity of each user in physical public spaces. Based on psychological theories of crossmodal attention that characterize human capabilities for matching information received through different modalities, the framework takes advantage of public displays and mobile devices through the use of peripheral cues and allows information personalization in public space. Two ex le systems are presented, in the first in iduals access situated ambient displays of directions to destinations, and in the second a structured combination of cues is used to provide access to information board displays. The configuration and implications for privacy of both systems is introduced and analyzed within the wider context of access to public information displays in pervasive computing.
Publisher: Elsevier BV
Date: 06-1998
DOI: 10.1016/S1078-5884(98)80120-2
Abstract: Esophageal leiomyoma is the most common benign submucosal mesenchymal tumor. Esophageal intraepithelial neoplasia includes low-grade and high-grade intraepithelial neoplasia. The coexistence of epithelial lesions and the subepithelial lesion is rare. We recorded a case of esophageal low-grade intraepithelial neoplasia (LGIN) overlying multiple esophageal leiomyomas and followed with a review of the literature. A 49-year-old female patient came for the treatment of esophageal lesions. The submucosal eminences were observed in the right posterior wall and the left anterior wall of the esophagus by Esophagogastroduodenoscopy (EGD). Additionally, we noticed the mucosa of the right wall with brown background color and the dilated, tortuous vessels by narrow-band imaging (NBI). Then we ensured that the submucosal lesions originated from the esophageal mucosal muscle by endoscopic ultrasonography (EUS) and enhanced CT. Subsequently, the submucosal eminence of the right posterior wall and the overlying mucosal lesion were removed together by endoscopic submucosal dissection (ESD). Postoperative pathological diagnosed esophageal submucosal leiomyoma with focal LGIN. Review EGD showed white scars on the right wall of the upper esophagus three months later, while pathological biopsy showed slight squamous epithelial hyperplasia in the left wall. We decided that the left submucosal lesion can be resected at a selective-time operation, and we continue to follow up as planned. The case of intraepithelial neoplasia overlying the submucosal tumor is rare. Either missed diagnosis or overdiagnosis should be avoided through EGD and pathological biopsy.
Publisher: Springer Science and Business Media LLC
Date: 15-05-2015
Publisher: Cambridge University Press (CUP)
Date: 2016
Publisher: Association for Computing Machinery (ACM)
Date: 25-06-2015
DOI: 10.1145/2776885
Abstract: Community + Culture features practitioner perspectives on designing technologies for and with communities. We highlight compelling projects and provocative points of view that speak to both community technology practice and the interaction design field as a whole. --- Christopher A. Le Dantec, Editor
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 04-2009
DOI: 10.1109/MPRV.2009.35
Publisher: ACM
Date: 23-11-2009
Publisher: Springer Berlin Heidelberg
Date: 2013
Publisher: SAGE Publications
Date: 03-2007
DOI: 10.1345/APH.1H475
Abstract: To report a case of probable fenofibrate-induced gynecomastia. A 56-year-old white hypercholesterolemic man was treated with fenofibrate 160 mg/day for 1 year. During the course of treatment, he developed gynecomastia on the left side, which resolved after the drug was stopped and replaced with alpha tocopherol acetate. Sixteen months after fenofibrate discontinuation, the patient was rechallenged and subsequently developed gynecomastia symptoms on the right side. The usual etiologies of gynecomastia were excluded by careful assessment of the patient's medical history, physical examination, and results of diagnostic tests such as chest X-ray, mammography, scrotal ultrasonography, routine blood chemistry, and extensive hormonal panel. Gynecomastia again resolved after discontinuation of fenofibrate. In this case, the resolution of gynecomastia on discontinuation of fenofibrate and recurrence after rechallenge highly suggest the role of fenofibrate. Use of the Naranjo probability scale registered causality as probable. Case reports of gynecomastia caused by different drugs have been previously published, but, to our knowledge, this is the first report linking gynecomastia to the use of fenofibrate. The pathogenesis of this adverse drug reaction remains unclear. Although fenofibrate-induced gynecomastia appears to be uncommon, patients receiving this medication should be monitored for this adverse drug reaction.
Publisher: Elsevier BV
Date: 05-1995
DOI: 10.1016/0278-6915(94)00149-I
Abstract: A 52-wk toxicity study by dietary administration was performed in Sprague-Dawley rats and in pure-bred beagle dogs with beta-cyclodextrin, a starch derivative that acts as a molecular inclusion agent. Doses of 0 (control), 12,500, 25,000 and 50,000 ppm were selected for the rat study, and 0 (control), 6200, 12,500 and 50,000 ppm were selected for the dog study. The liver and kidney were identified at the histopathological examination as target organs for toxicity in the rat at doses of 50,000 and 25,000 ppm, with the hepatic changes associated with increased plasma liver enzyme and reduced plasma triglyceride concentrations. In the dog study, there was no pathological evidence of systemic toxicity, although there were minor changes in urinalysis and biochemical parameters and a slightly higher incidence of liquid faeces. These changes were considered to be of no toxicological importance. The results in these studies, therefore, indicate that the non-toxic effect level was 12,500 ppm in the rat (equivalent to 654 or 864 mg/kg/day for males or females, respectively) and 50,000 ppm in the dog (equivalent to 1831 or 1967 mg/kg/day for males or females, respectively).
Publisher: Springer Berlin Heidelberg
Date: 2007
Publisher: ACM
Date: 03-12-2012
Publisher: ACM
Date: 04-04-2009
Publisher: Springer Berlin Heidelberg
Date: 2010
Publisher: Springer Berlin Heidelberg
Date: 2010
Publisher: Springer Berlin Heidelberg
Date: 2010
Publisher: ACM
Date: 27-04-2013
Publisher: JMIR Publications Inc.
Date: 08-2017
Abstract: ecreational sun exposure has been associated with melanoma prevalence, and tourism settings are of particular interest for skin cancer prevention. Effective, affordable, and geographically flexible interventions to promote sun protection are needed. he aim of this study was to describe the protocol for a definitive randomized controlled trial (RCT) evaluating a smartphone mobile intervention (mISkin app) promoting sun protection in holidaymakers and to assess the acceptability and feasibility of the mISkin app and associated trial procedures in an internal pilot study. articipants were recruited from the general community. Holidaymakers traveling abroad and owning a smartphone were enrolled in the internal pilot of a 2 (mISkin vs control) x 2 (sun protection factor [SPF] 15 vs SPF 30) RCT with a postholiday follow-up. The smartphone app is fully automated and entails a behavioral intervention to promote sun protection. It consisted of five components: skin assessment, educational videos, ultraviolet (UV) photos, gamification, and prompts for sun protection. Participants were also randomly allocated to receive sunscreen SPF 15 or SPF 30. Primary outcomes for the internal pilot study were acceptability and feasibility of trial procedures and intervention features. Secondary outcomes were collected at baseline and after holidays through face-to-face-assessments and included skin sun damage, sunscreen use (residual weight and application events), and sun protection practices (Web-based questionnaire). rom 142 registers of interest, 42 participants were randomized (76% [32/42] female mean age 35.5 years). Outcome assessments were completed by all participants. Random allocation to SPF 15 versus SPF 30 was found not to be feasible in a definitive trial protocol. Of the 21 people allocated to the mISkin intervention, 19 (91%) installed the mISkin on their phones, and 18 (86%) used it at least once. Participants were satisfied with the mISkin app and made suggestions for further improvements. Due to difficulties with the random allocation to SPF and slow uptake, the trial was discontinued. he internal pilot study concluded that randomization to SPF was not feasible and that recruitment rate was slower than expected because of difficulties with gatekeeper engagement. Possible solutions to the problems identified are discussed. Further refinements to the mISkin app are needed before a definitive trial. nternational Standard Randomized Controlled Trial Number ISRCTN63943558 www.isrctn.com/ISRCTN63943558 (Archived by WebCite at xOLvbab8)
Publisher: ACM
Date: 07-09-2015
Publisher: IEEE
Date: 2006
Publisher: Springer Berlin Heidelberg
Date: 2009
Publisher: Springer Science and Business Media LLC
Date: 26-03-2003
DOI: 10.1007/S00259-003-1138-9
Abstract: These guidelines on the use of radioiodinated (99m)Tc-MIBG scintigraphy in children, which summarise the views of the Paediatric Committee of the European Association of Nuclear Medicine, provide a framework which may prove helpful to nuclear medicine teams in daily practice. They have been influenced by the conclusions of the "Consensus Guidelines for MIBG Scintigraphy" (Paris, November 6, 1997) of the European Neuroblastoma Group and by those of the Oncological Committee of the French Society of Nuclear Medicine. The guidelines should be taken in the context of "good practice" and any local/national rules which apply to nuclear medicine examinations.
Publisher: Wiley
Date: 21-04-2016
DOI: 10.1118/1.4946814
Publisher: ACM
Date: 19-04-2023
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 04-2011
DOI: 10.1109/MC.2011.112
Publisher: Elsevier BV
Date: 06-2007
Publisher: Elsevier BV
Date: 03-2002
DOI: 10.1016/S0003-3944(01)00713-1
Abstract: Intraoperative MIBG radionuclear scanning has been used to improve pathological foci localization and surgical accuracy in patients with neural crest derived tumors. This intraoperative detection has been reported in less than 10 patients during reoperation for pheochromocytoma. We report a case of 123I-MIBG intraoperative detection allowing to improve surgical resection quality during reoperation for pheochromocytoma. The use of intraoperative MIBG radionuclear scanning is helpful when reoperation for pheochromocytoma is performed.
Publisher: Springer Science and Business Media LLC
Date: 23-06-2000
Abstract: In patients unable to perform a maximal exercise test, dipyridamole single-photon emission tomography (SPET) has a higher capacity than exercise SPET to detect coronary artery disease (CAD). However, in patients with myocardial ischaemia who are able to perform a maximal exercise test, it is not known whether these two tests may be equally used to assess the areas of myocardial ischaemia. This study was aimed at comparing the results provided by dipyridamole and exercise SPET in CAD patients with documented exercise myocardial ischaemia. Forty CAD patients who had undergone exercise thallium-201 SPET and who had myocardial ischaemia documented by an unequivocally positive exercise test underwent an additional 201Tl SPET study after dipyridamole infusion and low-level (40 W) exercise. The extent of defects was compared between the two tests and predictors of discrepant results were sought among data from exercise testing and coronary angiography. The extent of SPET defects was equivalent between the two tests in only 11 patients (28%), larger defects being observed with exercise in 18 [average difference: 12%+/-5% of left ventricle (LV)] and with dipyridamole in 11 (average difference: 15%+/-11% of LV). The best independent predictors of discrepancies between the two tests were: (1) increase in heart rate at exercise SPET, with defects being smaller at exercise than after dipyridamole in none of the patients with an increase >60 bpm (0/14), but in 42% of the others (11/26 P=0.004) and (2) an ischaemic territory related to a <70% coronary stenosis, for which SPET defects were always induced at exercise (10/10) but in only 30% (3/10) with dipyridamole (P=0.0004). Exercise and dipyridamole SPET provide different estimates of myocardial ischaemic areas. Dipyridamole allows the unmasking of perfusion abnormalities in patients who have low increases in heart rate at exercise SPET. However, dipyridamole is also much less efficient at inducing perfusion abnormalities in the ischaemic areas supplied by coronary stenoses of intermediate severity at rest angiography.
Publisher: ACM
Date: 19-04-2023
Publisher: ACM
Date: 19-04-2023
Publisher: JMIR Publications Inc.
Date: 27-02-2018
DOI: 10.2196/DERMA.8608
Publisher: ACM
Date: 09-06-2009
Publisher: Elsevier BV
Date: 02-2000
DOI: 10.1016/S1053-0770(00)90052-1
Abstract: To assess hemodynamic stability, postoperative pain management, and the control and timing of early extubation of a total intravenous anesthetic technique using propofol target-controlled infusion (TCI) and remifentanil in cardiac surgery. Prospective study. University hospital. Fifty patients scheduled for elective cardiac surgery. Premedication consisted of oral midazolam, 0.1 mg/kg. Anesthesia was induced with propofol TCI at a target concentration of 1.5 to 2 microg/mL remifentanil, 1 microg/kg and rocuronium. Anesthesia was maintained with propofol at the same target concentration and remifentanil titrated between 0.25 and 1 microg/kg/min. Thirty minutes before the end of surgery, a 0.1-mg/kg bolus of morphine was administered intravenously. Postoperative sedation was achieved by maintaining the propofol infusion until the patient was deemed ready for extubation. Postoperative pain relief was evaluated using a visual analog scale. The intervals between arrival in the intensive care unit, spontaneous ventilation, and extubation were recorded. Included in this study were 36 men and 14 women (American Society of Anesthesiologist = III New York Heart Association = II) scheduled for cardiac surgery. All patients remained hemodynamically stable throughout the perioperative period. Thirty-seven patients were successfully extubated during the first 4 postoperative hours. Spontaneous breathing was achieved at a mean interval of 15+/-5 minutes after propofol discontinuation. The mean interval to extubation was 163+/-45 minutes after arrival in the intensive care unit. Extubation was performed 48+/-12 minutes after patients were considered ready to awaken. During spontaneous ventilation, 36 patients received additional boluses of morphine (mean, 2.5+/-1 mg). Subsequently, all patients achieved a visual analog scale less than 40 mm. The combination of remifentanil and propofol TCI resulted in hemodynamic stability and good postoperative analgesia. This technique allows physicians to schedule the time of extubation in patients undergoing cardiac anesthesia.
Publisher: ACM
Date: 21-06-2014
Publisher: European Respiratory Society (ERS)
Date: 09-2002
DOI: 10.1183/09031936.02.00892001
Abstract: The aim of this study was to determine whether perfusion-scintillation scanning, used as a predictive pre-operative index of lung functionality in patients with lung cancer, is affected by the level of pulmonary blood flow (PBF). Twenty patients with primary lung cancer underwent spirometry and a radionuclide-perfusion scan (macroaggregated albumin particles labelled with 99mTechnetium) both at rest and during the last minute of a r -like increase in work rate until exhaustion. On average, the perfusion of the lung with the tumour was significantly reduced by the same magnitude at rest and during exercise (mean+/-SD: -9+/-6% versus -10+/-4% of the cardiac output), regardless of the extent of the tumour. However, subject-by-subject analysis revealed that in two patients, a larger decrease in the perfusion of the lung with the tumour was observed during exercise than at rest (-11% and -17%, respectively). This leads to an underestimation of predictive postoperative functional parameters if resting values are used in these patients. The use of perfusion scintigraphy at rest therefore gives a clear picture of the functionality of the lung before resection in most patients requiring surgery.
Publisher: Springer Berlin Heidelberg
Date: 2008
Publisher: ACM
Date: 07-05-2016
Publisher: Association for Computing Machinery (ACM)
Date: 28-09-2023
DOI: 10.1145/3610174
Publisher: Elsevier BV
Date: 2016
DOI: 10.1016/J.DIII.2014.11.038
Abstract: Whilst the detailed X-ray features of thoracic manifestations of sarcoidosis are now clearly defined and known by most radiologists, the same does not apply to osteoarticular and muscular features of the disease, which may however raise major diagnostic problems, either because they are the presenting features of the disease (7% of cases) or because they develop during its course. The bony lesions of sarcoid dactylitis (classical Perthes-Jüngling disease) are very characteristic and well known. Many other presentations of bone and bone marrow sarcoidosis may however raise major diagnostic difficulties, particularly uni- or multifocal osteolytic and sclerotic forms of the disease. The articular manifestations of sarcoidosis are difficult to distinguish from those of the other inflammatory and degenerative arthropathies. The muscular lesions in sarcoidosis are generally clinically silent and therefore often missed. MRI has shown them to be very common in active sarcoidosis. Acute forms carry a good prognosis whereas chronic lesions are a presenting feature of multi-organ sarcoidosis. Finally, clinicians should always think about the possibility of an iatrogenic origin for musculoskeletal abnormalities seen in sarcoidosis, particularly those related to corticosteroid therapy.
Publisher: Cambridge University Press (CUP)
Date: 2015
Publisher: Springer Berlin Heidelberg
Date: 2006
DOI: 10.1007/11795018_15
Publisher: IEEE
Date: 03-2012
Publisher: Oxford University Press (OUP)
Date: 21-08-2013
DOI: 10.1093/IWC/IWT038
Publisher: Elsevier BV
Date: 1989
Publisher: Springer London
Date: 2007
Publisher: Elsevier BV
Date: 2014
Publisher: Informa UK Limited
Date: 06-1996
Publisher: ACM
Date: 25-06-2014
Publisher: ACM
Date: 22-01-2011
Publisher: Wiley
Date: 15-03-1999
Publisher: ACM
Date: 06-10-2013
Publisher: ACM
Date: 27-04-2013
Publisher: Elsevier BV
Date: 05-2011
Publisher: ACM
Date: 18-04-2015
Publisher: The Royal Society
Date: 13-07-2009
Abstract: The AMUC (Associated Motion capture User Categories) project consisted of building a prototype sketch retrieval client for exploring motion capture archives. High-dimensional datasets reflect the dynamic process of motion capture and comprise high-rate s led data of a performer's joint angles in response to multiple query criteria, these data can potentially yield different kinds of information. The AMUC prototype harnesses graphic input via an electronic tablet as a query mechanism, time and position signals obtained from the sketch being mapped to the properties of data streams stored in the motion capture repository. As well as proposing a pragmatic solution for exploring motion capture datasets, the project demonstrates the conceptual value of iterative prototyping in innovative interdisciplinary design. The AMUC team was composed of live performance practitioners and theorists conversant with a variety of movement techniques, bioengineers who recorded and processed motion data for integration into the retrieval tool, and computer scientists who designed and implemented the retrieval system and server architecture, scoped for Grid-based applications. Creative input on information system design and navigation, and digital image processing, underpinned implementation of the prototype, which has undergone preliminary trials with erse users, allowing identification of rich potential development areas.
Publisher: ACM
Date: 26-04-2014
Publisher: ACM
Date: 26-04-2014
Publisher: IGI Global
Date: 2013
DOI: 10.4018/IJCALLT.2013010104
Abstract: This paper reports on the French Digital Kitchen, a design-based project which drew on digital sensor technology to take the principles of Task-Based Language Teaching (TBLT) out of the classroom and into the real-world environment of a kitchen. The project aimed to produce a situated language learning environment where learners could learn aspects of French language and cuisine whilst performing a real-world task. The article describes the blend of TBLT, human-computer interaction (HCI) and user-centred design (UCD) principles the authors adopted in constructing and trialling the kitchen, using multiple data sources. An ex le of a task cycle is then presented to illustrate (by using CA analysis of transcripts) how learners have used the resources of the kitchen to accomplish the task. The authors’ findings show how the integration of the pedagogical and technological design enabled learners to notice and manipulate new vocabulary items.
Publisher: Public Library of Science (PLoS)
Date: 28-06-2012
Publisher: Springer Berlin Heidelberg
Date: 27-11-2006
Publisher: ACM
Date: 28-02-2015
Publisher: Association for Computing Machinery (ACM)
Date: 14-04-2023
DOI: 10.1145/3579478
Abstract: Previous research on employee voice has sought to design technological solutions that address the challenges of speaking up in the workplace. However, effectively embedding employee voice systems in organisations requires designers to engage with the social processes, power relations and contextual factors of in idual workplaces. We explore this process within a university workplace through a research project responding to a crisis in educational service delivery arising from the COVID-19 pandemic. Within a successful three-month staff-led engagement, we examined the intricacies of embedding employee voice, exploring how the interactions between existing actors impacted the effectiveness of the process. We sought to identify specific actions to promote employee voice and overcome barriers to its successful establishment in organisational decision-making. We highlight design considerations for an effective employee voice system that facilitates embedding employee voice, including assurance, bounded accountability and bias reflexivity.
Publisher: Springer International Publishing
Date: 2017
Publisher: Springer Science and Business Media LLC
Date: 16-07-2005
Publisher: ACM
Date: 05-05-2012
Publisher: ACM
Date: 05-05-2012
Publisher: ACM
Date: 10-04-2010
Publisher: Association for Computing Machinery (ACM)
Date: 30-06-2017
DOI: 10.1145/3090081
Abstract: We present a system for making emissive computer displays (LCDs) look like they are reflective, i.e. not emitting light but instead reflecting ambient light, an effect that we call a “calm display”. We achieve this effect by using a light sensor and a one-time calibration process to drive an algorithm which controls the display's backlight intensity and gamma correction functionality to continually match the brightness and chromaticity of the ambient light. We present an experimental evaluation of our system, showing quantitatively that the color and brightness output by our system is perceptually close to that of a piece of paper under similar lighting conditions. We argue that calm displays can more easily fade into the background, and further that they are more suitable for environments such as bedrooms where glowing displays are often out-of-place. We validate these claims and more generally explore users’ perception of calm displays, through a field study of an LCD display deployed in participants’ bedrooms.
Publisher: ACM
Date: 21-04-2018
Publisher: ACM
Date: 26-04-2014
Publisher: Springer Science and Business Media LLC
Date: 1999
Publisher: Wiley
Date: 06-11-2019
DOI: 10.1002/CAPR.12275
Publisher: JMIR Publications Inc.
Date: 07-05-2022
Abstract: mproving preconception health can benefit all women, their children and families, regardless of their in idual pregnancy intentions. xplore how women engage with digital health resources and online platforms to inform the design and development of a digital health resource to support women to make positive behaviour change for their preconception health. his co-design research followed the Double Diamond process. Phase one, contextualisation and explorative processes to develop a design brief, was undertaken via a series of in-depth interviews with female participants (n = 12) aged 18-45 years over three months. Community advisors (n = 8) provided feedback throughout the process. Qualitative analyses of transcripts from interviews was undertaken by two researchers before a deductive process identified themes mapped to the COM-B framework. ine themes and eight sub-themes were identified. Participants were already engaging with a range of digital health resources and had high expectations of these. Digital health resources needed to be easy to access, make women’s busy lives easier, be evidence-based, and be reputable. Social connectedness was also highly important to our participants, with information and advice from peers with similar experiences being preferred over yet more online health information. o-designed digital health resources should be evidence-based, reputable and easy to access. Social connections were considered highly important to women and designers of digital health resources should consider how they can increase opportunities for women to connect and learn from each other to promote health behaviours.
Publisher: Springer Science and Business Media LLC
Date: 25-07-2014
DOI: 10.1007/S11523-014-0328-7
Abstract: Antineoplastic drugs are one of the pharmacological classes more frequently involved in occurrence of "serious" adverse drug reactions. However, few epidemiological data are available regarding the preventability of adverse drug reactions with ambulatory cancer chemotherapy. We assessed the rate and characteristics of "preventable" or "potentially preventable" "serious" adverse drug reactions induced by oral protein kinase inhibitors (PKIs). We performed a retrospective study with all "serious" adverse drug reactions (ADRs) recorded from 1 January 2008 to 31 December 2009 in the French Pharmacovigilance Database with the eight oral protein kinase inhibitors marketed in France: sorafenib, imatinib, erlotinib, sunitinib, dasatinib, lapatinib, nilotinib and everolimus (Afinitor®) using the French adverse drug reactions preventability scale. This study was carried out on 265 spontaneous notifications. Most of adverse drug reactions were "unpreventable" (63.8 %). Around one third were "unevaluable" due to notifications poorly documented (medical history, dosage, use of drugs as first or second intention, concomitant drugs). One (0.4 %) adverse drug reaction was "preventable" with dasatinib (subdural hematoma) and three (1.1 %) were "potentially preventable" (hepatic adverse drug reactions): two with imatinib and one with sorafenib. For these four cases, we identified some characteristics: incorrect dosages, drug interactions and off-label uses. An appropriate prescription could avoid the occurrence of 1.5 % "serious" adverse drug reactions with oral PKIs. This rate is low and further studies are needed to compare our results by using other preventability instruments and to improve the French ADRs Preventability Scale.
Publisher: Springer Science and Business Media LLC
Date: 1994
DOI: 10.1007/BF00849071
Publisher: JMIR Publications Inc.
Date: 06-07-2020
DOI: 10.2196/14283
Abstract: Lebanon currently hosts around one million Syrian refugees. There has been an increasing interest in integrating eHealth and mHealth technologies into the provision of primary health care to refugees and Lebanese citizens. We aimed to gain a deeper understanding of the potential for technology integration in primary health care provision in the context of the protracted Syrian refugee crisis in Lebanon. A total of 17 face-to-face semistructured interviews were conducted with key informants (n=8) and health care providers (n=9) involved in the provision of health care to the Syrian refugee population in Lebanon. Interviews were audio recorded and directly translated and transcribed from Arabic to English. Thematic analysis was conducted. Study participants indicated that varying resources, primarily time and the availability of technologies at primary health care centers, were the main challenges for integrating technologies for the provision of health care services for refugees. This challenge is compounded by refugees being viewed by participants as a mobile population thus making primary health care centers less willing to invest in refugee health technologies. Lastly, participant views regarding the health and technology literacies of refugees varied and that was considered to be a challenge that needs to be addressed for the successful integration of refugee health technologies. Our findings indicate that in the context of integrating technology into the provision of health care for refugees in a low or middle income country such as Lebanon, some barriers for technology integration related to the availability of resources are similar to those found elsewhere. However, we identified participant views of refugees’ health and technology literacies to be a challenge specific to the context of this refugee crisis. These challenges need to be addressed when considering refugee health technologies. This could be done by increasing the visibility of refugee capabilities and configuring refugee health technologies so that they may create spaces in which refugees are empowered within the health care system and can work toward debunking the views discovered in this study.
Publisher: Elsevier BV
Date: 12-2014
Publisher: Elsevier BV
Date: 04-1995
DOI: 10.1016/0887-2333(94)00209-D
Abstract: The effects of three polyols, mannitol, sorbitol and xylitol, on primary cultures of rat hepatocytes were studied with the aid of two cytotoxicity markers, the MTT test and the neutral red assay. A dose-related increase in the uptake of neutral red (up to approximately 60%) was observed in comparison with untreated cells, whereas the MTT test was unaffected by concentrations of polyols up to 330 mM (620 mOsmol/litre). The increase in neutral red uptake does not indicate cellular toxicity as it was reversible and was shown to be due to an increase in the size of lysosomes. For compounds acting on cellular metabolism, such as phenol, mercuric chloride and pentobarbital, it was shown that the increase in neutral red uptake may minimize any cytotoxic effect of these compounds. The neutral red assay should therefore be used with caution when testing compounds that provoke lysosomal swelling. We recommend the use of multiple, mechanistically different, cytotoxicity markers for the evaluation of xenobiotic cytotoxicity.
Publisher: ACM
Date: 23-07-2008
Publisher: Elsevier BV
Date: 12-2007
DOI: 10.1016/J.ARCPED.2007.08.013
Abstract: Acyclovir is a synthetic nucleoside analogue active against herpes viruses. Exposure during human pregnancy and during the neonatal period seems safe. We report a case of early necrotizing enterocolitis in a full term infant treated with acyclovir as a prophylactic therapy. The mother had herpes genitalis with preterm, premature ruture of membranes at 32 weeks of gestational age and was treated with acyclovir until vaginal delivery. Acyclovir treatment in utero and after birth is discussed as a possible cause of necrotizing enterocolitis in the infant. Acyclovir should be used only if its benefit outweighs the potential risk to the baby.
Publisher: Elsevier BV
Date: 10-2011
Publisher: ACM
Date: 17-06-2013
Publisher: SciTePress - Science and and Technology Publications
Date: 2011
Publisher: Cambridge University Press (CUP)
Date: 05-02-2009
Publisher: Springer Berlin Heidelberg
Date: 2010
Publisher: JMIR Publications Inc.
Date: 05-12-2022
DOI: 10.2196/39238
Abstract: Chronic diseases and the associated risk factors are preventable with lifestyle changes such as eating a healthier diet and being more physically active. In Malaysia, the prevalence of chronic diseases, including diabetes, hypertension, and heart diseases, has risen. In the present study, we explore the potential of co-designing and implementing a digital wellness intervention to promote socially-driven health knowledge and practices in the workplace in Malaysia, drawing on social cognitive theory, social impact theory, and social influence theory. This study aims to co-design and assess the feasibility of a socially-driven digital health intervention to promote healthy behavior and prevent chronic diseases in a workplace in Malaysia. This study involves two phases: (i) identifying the barriers and facilitators to healthy behaviors at work and co-designing the intervention activities with the employees, (ii) implementing and evaluating the intervention’s feasibility. Phase 1 will involve qualitative data collection and analysis through semi-structured, in-depth interviews and co-design workshops with the employees, while Phase 2 will consist of a feasibility study employing quantitative measurements of health behaviors through accelerometers and questionnaires. This study was funded in June 2021 and ethics approval for Phase 1 was obtained from the Monash University Human Research Ethics Committee in January 2022. As of August 2022, qualitative interviews with 12 employees have been completed and the data has been transcribed and analyzed. These results will be published in a future paper with results from all Phase 1 activities. The study will help us to better understand the mechanisms through which digital technologies can promote socially-driven health knowledge and behaviors. This research will also result in a scalable wellness intervention that could be further tailored and expanded to other employers and social groups across the region. PRR1-10.2196/39238
Publisher: ACM
Date: 13-09-2014
Publisher: Association for Computing Machinery (ACM)
Date: 12-2012
Abstract: The ratio of healthcare professionals to care recipients is dropping at an alarming rate, particularly for the older population. It is estimated that the number of persons with Alzheimer's disease, for ex le, will top 100 million worldwide by the year 2050 [Alzheimer's Disease International 2009]. It will become harder and harder to provide needed health services to this population of older adults. Further, patients are becoming more aware and involved in their own healthcare decisions. This is creating a void in which technology has an increasingly important role to play as a tool to connect providers with recipients. Ex les of interactive technologies range from telecare for remote regions to computer games promoting fitness in the home. Currently, such technologies are developed for specific applications and are difficult to modify to suit in idual user needs. The future potential economic and social impact of technology in the healthcare field therefore lies in our ability to make intelligent devices that are customizable by healthcare professionals and their clients, that are adaptive to users over time, and that generalize across tasks and environments. A wide application area for technology in healthcare is for assistance and monitoring in the home. As the population ages, it becomes increasingly dependent on chronic healthcare, such as assistance for tasks of everyday life (washing, cooking, dressing), medication taking, nutrition, and fitness. This article will present a summary of work over the past decade on the development of intelligent systems that provide assistance to persons with cognitive disabilities. These systems are unique in that they are all built using a common framework, a decision-theoretic model for general-purpose assistance in the home. In this article, we will show how this type of general model can be applied to a range of assistance tasks, including prompting for activities of daily living, assistance for art therapists, and stroke rehabilitation. This model is a Partially Observable Markov Decision Process (POMDP) that can be customized by end-users, that can integrate complex sensor information, and that can adapt over time. These three characteristics of the POMDP model will allow for increasing uptake and long-term efficiency and robustness of technology for assistance.
Publisher: Geological Society of London
Date: 05-1998
Publisher: Elsevier BV
Date: 10-2013
Publisher: Springer Science and Business Media LLC
Date: 31-10-1997
Publisher: Springer Science and Business Media LLC
Date: 08-2003
DOI: 10.1016/S1071-3581(03)00429-X
Abstract: Beta-blockers are potent anti-ischemic medications, able to improve prognosis in patients with coronary artery disease (CAD). However, it is not known whether beta-blockers have the same beneficial prognostic effect when residual ischemia persists on treatment. The prognostic impact of exercise single photon emission computed tomography (SPECT) ischemia was analyzed in 442 patients with chronic CAD, who were treated with beta-blockers and who were referred to exercise thallium 201 SPECT, while they were receiving their daily-life medications. Ischemic and viable myocardium was documented on Tl-201 SPECT in 190 patients (43%), of whom only 23% had angina and only 26% had positive exercise testing results. During a follow-up of 3.8 +/- 1.7 years, 36 patients died and survival curves were progressively ergent between patients with and those without ischemic and viable myocardium: at 5 years, the respective survival rates were 81% +/- 4% and 94% +/- 2% (P =.004). By multivariate analysis, the best independent predictors of death were large extent of necrosis (>25% of left ventricle on Tl-201 SPECT, P <.001) and ischemic and viable myocardium (P =.001). In the CAD patients treated on a long-term basis with beta-blockers, survival is strongly influenced by persistent exercise SPECT ischemia on treatment. Therefore exercise SPECT on treatment could be a useful tool for selecting those who might benefit from additional anti-ischemic therapeutic interventions.
Publisher: Association for Computing Machinery (ACM)
Date: 19-12-2017
DOI: 10.1145/3144569
Abstract: User identification on interactive surfaces is a desirable feature that is not inherently supported by existing technologies. We have conducted an extensive survey of existing identification techniques, which led us to formulate a unified model for user identification. We start by introducing this model that (1) classifies existing user identification approaches in five categories according to the identification technology, (2) identifies eight characteristic identification system parameters, and (3) proposes a way for visualizing the system's characteristics as points on a radar chart to allow for quick comparison and contrast between systems. This model is then used to present our survey of existing user identification approaches and visualize their characteristics, highlighting their strengths and limitations. The model also makes it possible to visually represent requirements of systems that require user identification, identify existing approaches that can meet an application's requirements, and help report on and evaluate new approaches to user identification systematically.
Publisher: IEEE
Date: 1991
Publisher: Institution of Engineering and Technology (IET)
Date: 1985
DOI: 10.1049/EL:19850587
Publisher: ACM
Date: 21-04-2018
Publisher: Springer Science and Business Media LLC
Date: 03-2018
Publisher: ACM
Date: 10-04-2010
Publisher: Springer Netherlands
Date: 1997
Publisher: Springer Science and Business Media LLC
Date: 22-09-2015
Publisher: IGI Global
Date: 2014
DOI: 10.4018/978-1-4666-6042-7.CH046
Abstract: This paper reports on the French Digital Kitchen, a design-based project which drew on digital sensor technology to take the principles of Task-Based Language Teaching (TBLT) out of the classroom and into the real-world environment of a kitchen. The project aimed to produce a situated language learning environment where learners could learn aspects of French language and cuisine whilst performing a real-world task. The article describes the blend of TBLT, human-computer interaction (HCI) and user-centred design (UCD) principles the authors adopted in constructing and trialling the kitchen, using multiple data sources. An ex le of a task cycle is then presented to illustrate (by using CA analysis of transcripts) how learners have used the resources of the kitchen to accomplish the task. The authors' findings show how the integration of the pedagogical and technological design enabled learners to notice and manipulate new vocabulary items.
Publisher: ACM
Date: 10-07-2023
Publisher: Wiley
Date: 03-1993
DOI: 10.1007/BF02536637
Publisher: Elsevier BV
Date: 02-1999
DOI: 10.1016/S1053-0770(99)90164-7
Abstract: In the present study, the authors compared continuous infusion to bolus administration of sufentanil and midazolam in patients undergoing mitral valve surgery. The purpose of the study was to evaluate the hemodynamic variability, total dose, effective plasma drug concentrations, and simplicity of the two anesthetic techniques. Prospective, randomized study. University hospital. Thirty patients scheduled for elective mitral valve surgery. Induction of anesthesia was similar in both groups and consisted of sufentanil, up to 2 microg/kg, and midazolam, 0.05 to 0.15 mg/kg, followed by atracurium, 0.5 mg/kg. Anesthesia was maintained in the bolus group with predetermined boluses of sufentanil, 2 microg/kg, and midazolam, 0.03 mg/kg. Boluses were not administered if blood pressure was within 20% of baseline. The continuous-infusion group received sufentanil, 3.6 microg/kg/h, and midazolam, 0.08 mg/kg/h, started immediately after induction. The infusion rate was reduced to sufentanil, 1.8 microg/kg/h, and midazolam, 0.04 mg/kg/h, after sternotomy and was discontinued at skin closure. Atracurium was infused at a rate of 0.5 mg/kg/h up to sternal closure in both groups. No inhalation agents were used. Hemodynamic variability between the groups was not significant. Total sufentanil dose was 773 +/- 186 microg in the continuous-infusion group and 610 +/- 184 microg in the bolus group (p = 0.01). Total midazolam dose was 14.4 +/- 3 mg and 11.2 +/- 3 mg in the continuous-infusion and bolus groups, respectively. There were 3.46 (range, 0 to 7) additional bolus injections in the bolus group and 0.31 (range, 0 to 1) in the continuous-infusion group (p < 0.001). Plasma sufentanil concentrations at extubation were similar in both groups (0.5 ng/mL). Plasma midazolam concentrations at extubation in the bolus group (17 +/- 6.7 ng/mL) were similar to those in the continuous-infusion group (23 +/- 5 ng/mL). The simplicity of the continuous infusion is a major advantage. This technique provides hemodynamically safe and stable conditions similar to those of bolus administration.
Publisher: ACM
Date: 19-04-2023
Publisher: Public Library of Science (PLoS)
Date: 02-2017
Publisher: SPIE
Date: 14-09-1993
DOI: 10.1117/12.154621
Publisher: Elsevier BV
Date: 06-1997
Publisher: Elsevier BV
Date: 11-2015
Publisher: ACM
Date: 13-07-2015
Publisher: Cold Spring Harbor Laboratory
Date: 17-10-2022
DOI: 10.1101/2022.10.16.22280934
Abstract: Circadian rhythm disturbance is a common feature of many psychiatric disorders. Light is the primary input to the circadian clock, with daytime light strengthening rhythms and night light disrupting them. Therefore, habitual light exposure may represent an environmental risk factor for susceptibility to psychiatric disorders. We performed the largest to-date cross-sectional analysis of light, sleep, physical activity, and mental health ( n = 86,772 adults aged 62.4 ± 7.4 years 57% women). We examined the independent association of day and night light exposure with covariate-adjusted risk for psychiatric disorders and self-harm. Greater night light exposure was associated with increased risk for major depressive disorder, generalized anxiety disorder, PTSD, psychosis, bipolar disorder, and self-harm behavior. Independent of night light, greater day light exposure was associated with reduced risk for major depressive disorder, PTSD, psychosis, and self-harm behavior. These findings were robust to adjustment for sociodemographics, photoperiod, physical activity, and sleep quality. Avoiding light at night and seeking light during the day may be a simple and effective, non-pharmacological means of broadly improving mental health.
Publisher: JMIR Publications Inc.
Date: 08-04-2019
Abstract: ebanon currently hosts around one million Syrian refugees. There has been an increasing interest in integrating eHealth and mHealth technologies into the provision of primary health care to refugees and Lebanese citizens. e aimed to gain a deeper understanding of the potential for technology integration in primary health care provision in the context of the protracted Syrian refugee crisis in Lebanon. total of 17 face-to-face semistructured interviews were conducted with key informants (n=8) and health care providers (n=9) involved in the provision of health care to the Syrian refugee population in Lebanon. Interviews were audio recorded and directly translated and transcribed from Arabic to English. Thematic analysis was conducted. tudy participants indicated that varying resources, primarily time and the availability of technologies at primary health care centers, were the main challenges for integrating technologies for the provision of health care services for refugees. This challenge is compounded by refugees being viewed by participants as a mobile population thus making primary health care centers less willing to invest in refugee health technologies. Lastly, participant views regarding the health and technology literacies of refugees varied and that was considered to be a challenge that needs to be addressed for the successful integration of refugee health technologies. ur findings indicate that in the context of integrating technology into the provision of health care for refugees in a low or middle income country such as Lebanon, some barriers for technology integration related to the availability of resources are similar to those found elsewhere. However, we identified participant views of refugees’ health and technology literacies to be a challenge specific to the context of this refugee crisis. These challenges need to be addressed when considering refugee health technologies. This could be done by increasing the visibility of refugee capabilities and configuring refugee health technologies so that they may create spaces in which refugees are empowered within the health care system and can work toward debunking the views discovered in this study.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 1993
DOI: 10.1109/36.210463
Publisher: JMIR Publications Inc.
Date: 03-02-2020
DOI: 10.2196/13266
Abstract: Under-reporting because of the limitations of human memory is one of the key challenges in dietary assessment surveys that use the multiple-pass 24-hour recall. Research indicates that shortening a retention interval (ie, the time between the eating event and recall) reduces the burden on memory and may increase the accuracy of the assessment. This study aimed to explore the accuracy and acceptability of Web-based dietary assessment surveys based on a progressive recall, where a respondent is asked to record multiple recalls throughout a 24-hour period using the multiple-pass protocol and portion size estimation methods of the 24-hour recall. The experiment was conducted with a dietary assessment system, Intake24, that typically implements the multiple-pass 24-hour recall method where respondents record all meals they had for the previous day on a single occasion. We modified the system to allow respondents to add multiple recalls throughout the day using the multiple-pass protocol and portion size estimation methods of the 24-hour recall (progressive recall). We conducted a dietary assessment survey with 33 participants, where they were asked to record dietary intake using both 24-hour and progressive recall methods for weekdays only. We compared mean retention intervals (ie, the time between eating event and recall) for the 2 methods. To examine accuracy, we compared mean energy estimates and the mean number of reported foods. Of these participants, 23 were interviewed to examine the acceptability of the progressive recall. Retention intervals were found to be, on average, 15.2 hours (SD 7.8) shorter during progressive recalls than those during 24-hour recalls. We found that the mean number of foods reported for evening meals for progressive recalls (5.2 foods) was significantly higher (P=.001) than that for 24-hour recalls (4.2 foods). The number of foods and the amount of energy reported for other meals remained similar across the 2 methods. In interviews, 65% (15/23) of participants said that the 24-hour recall is more convenient in terms of fitting in with their daily lifestyles, and 65% (15/23) of respondents indicated that they remembered meal content and portion sizes better with the progressive recall. The analysis of interviews and data from our study indicate that progressive recalls provide minor improvements to the accuracy of dietary assessment in Intake24. Additional work is needed to improve the acceptability of progressive recalls in this system.
Publisher: ACM
Date: 15-09-2014
Publisher: ACM
Date: 05-05-2012
Publisher: ACM
Date: 02-05-2017
Publisher: Informa UK Limited
Date: 03-1994
Publisher: Elsevier BV
Date: 07-1995
DOI: 10.1016/0890-6238(95)00026-7
Abstract: A 3-generation study with two mating phases per generation and a teratology phase was performed in the rat to assess the reproductive and developmental toxicity of beta-cyclodextrin (beta-CD) in the diet. Transient neonatal growth retardation occurred with 5% beta-CD: a similar, but equivocal, effect was also observed with 2.5%. No permanent defects or other indications of developmental toxicity were found. There was no significant maternal toxicity. The dietary level of 1.25% was found to be a NOAEL for developmental toxicity. Further investigations showed the growth retardation to be specific to dietary administration during lactation: it was not produced by parenteral (i.p.) administration and was not influenced by treatment of the dams or litters during gestation. Slight maternal nutritional deficiency, caused by physico-chemical interactions of beta-CD with nutrients in the gut is proposed as the mechanism of action. No difference in milk composition was found.
Publisher: Elsevier BV
Date: 09-1993
DOI: 10.1016/0002-8703(93)90406-Y
Abstract: The usefulness of exercise single photon emission computed tomography (SPECT)-thallium for detecting asymptomatic restenosis was assessed prospectively in 62 patients with angina before angioplasty, who underwent < or = 6-month re-angiography and exercise SPECT-thallium imaging. Among patients with restenosis, nine had recurrence of angina but eight did not. These two subgroups had equivalent percentages of restenosis (71 +/- 16% vs 64 +/- 16%, NS) and extent of reversible thallium defects (2.8 +/- 1.7 vs 4.1 +/- 2.6, NS), and both subgroups had poorer hemodynamic responses to exercise compared with patients without restenosis (maximal) rate-pressure product [X 100], 258 +/- 54 and 239 +/- 33 vs 302 +/- 61 p < 0.05 and p < 0.01, respectively). Exercise testing detected fewer patients with restenosis compared to exercise SPECT-thallium imaging, especially among asymptomatic patients (25% vs 100%, p < 0.005). Asymptomatic restenosis occurs frequently, induces an amount of stress ischemia equivalent to that of symptomatic restenosis, and is efficiently detected by exercise SPECT-thallium with rest-reinjection but not by exercise testing.
Publisher: ACM
Date: 07-05-2011
Publisher: Elsevier BV
Date: 02-2009
Publisher: IEEE
Date: 04-2014
Publisher: Springer Berlin Heidelberg
Date: 2009
Publisher: Elsevier BV
Date: 1989
DOI: 10.1016/0009-8981(89)90026-0
Abstract: Two monoclonal antibodies against human apolipoprotein A-I were characterized to recognize rabbit apo A-I. By immunoblotting we determined that while neither antibody reacted with the other rabbit apolipoproteins they both recognized all rabbit apo A-I isoforms. Cotitration revealed that each antibody bound to different apo A-I epitopes. Then we developed a noncompetitive enzyme-linked immunosorbent assay (ELISA) to measure the concentration of total apolipoprotein A-I in rabbit serum. The ELISA curves of the different lipoprotein class and serum showed the similarity of the expression of the apo A-I epitopes recognized in each of them and in serum. This assay, as opposed to other techniques, offers several advantages such as sensitivity, specificity, and simplicity and avoids the use of radioisotope.
Publisher: Elsevier
Date: 2003
Publisher: EDP Sciences
Date: 05-2002
DOI: 10.2113/173.3.207
Abstract: Introduction. – The Variscan basement of the French Massif Central is considered [Faure, 1995] to have suffered (i) a southwestward nappe stacking during the early Carboniferous (ii) a NW-SE trending extension during the late Visean and granite emplacement during Namurian and Westphalian time (iii) a NE-SW trending extension during late Carboniferous-early Permian. The structure of the Veinazès and Marcolès monzogranitic plutons, located in the Châtaigneraie (southern French Massif Central), is studied in this paper through the anisotropy of magnetic susceptibility technique (AMS) to better understand the effects of the Namurian-Westphalian phase which is poorly documented in this region. Magnetic and structural study. – The long axis K1 of the AMS ellipsoid represents the magnetic lineation and the short axis K3 is normal to the magnetic foliation. This magnetic fabric may be equated with the mineral fabric. Km, the mean magnetic susceptibility, corresponds to the arithmetic mean (K1+K2+K3)/3. Pp %, the magnetic anisotropy ratio, corresponds to ((K1 – D/K3 – D) – 1) × 100, D being the diamagnetic component. Magnetic susceptibility (K) values (fig. 3 table I) range from 3.5 to 18.9 × 10−5 SI (mean 12.3 × 10−5 SI) for Veinazès, and from 0.7 to 13.1 x 10−5 SI (mean 8.1 × 10−5 SI) for Marcolès. Such values are typical of dominantly paramagnetic rocks. This is confirmed by the very good correspondence between these measured values and the magnetic susceptibilities calculated from sites for which chemical analyses are available (table II). For Veinazès the highest K values are mainly located in the western part of the pluton, whereas the weakest are in the northeastern part (fig. 3). This corresponds roughly to the distribution of the main petrographic facies determined by Joubert [1978] and Bogdanoff et al. [1989a]. The anisotropy of the magnetic susceptibility ratio (Pp %) (fig. 4 table I) ranges from 0.9 % to 5.3 % (mean 2.2 %) for Veinazès and from 0.8 % to 4 % (mean 2.2 %) for Marcolès. The part of the Veinazès pluton located to the south-west of the Sansac-Montsalvy line displays a mean anisotropy (2.7 %) clearly higher than the northeastern part of the pluton (1.6 %). For Marcolès, the map of Pp % does not display significant distribution heterogeneities. Three types of microstructures were determined in thin-sections in the Veinazès and Marcolès granites (fig. 5) : 1–undeformed magmatic textures 2– late magmatic weakly deformed textures 3– late magmatic deformed textures. There is a good correspondence between the mapped distribution of these microstructures (fig. 6) and the Pp % values (fig. 4). Magnetic foliations (fig. 7 & 8 table I). Veinazès : to the north-east of the Sansac-Montsalvy line, the foliations are roughly organized in a dome. To the south-west of this line, the foliations are mainly WNW-ESE trending with a medium to steep northward dip. Near the borders of the pluton the foliations become WSW-ENE. Marcolès : the foliations are concentrated around a NW-SE trending mean direction, with generally steep (≥ 60o) and northeast dips. Near the extremities of the pluton the foliations are closer to an E-W trend. In both plutons the pattern of foliations tends to form Z-sigmoids. Magnetic lineations (fig. 7 & 9 table I). Veinazès : to the north-east of the pluton, the lineations display generally shallow plunges and N-S trending directions. In the central part of the pluton they display very shallow plunges and are mainly E-W trending. To the west, the lineations display shallow to steep plunges mainly trending either E-W or NW-SE. Marcolès : most lineations are NW-SE to E-W trending, with middle SE or eastward plunges. These lineations form a Z-sigmoid pattern in plan view. Discussion and interpretation. – The shallow plunging lineations carried by rather steep foliations and the sigmoidal features observed in plan view, show that most magmatic fabrics of both plutons may correspond to strike-slip movements. Moreover, the organization of the main cleavage in the country rocks around the Veinazès pluton could correspond to an E-W-trending left-lateral transcurrent zone (fig. 1). In the western part of the Châtaigneraie, the mean direction of the cleavage becomes N150oE-165oE, with eastward middle to steep dips, indicating a clockwise rotation with respect to the regional trend. Dextral shearings are linked to this NNW-SSE band. Gravimetric data indicate that the Veinazès pluton is characterized by a rather flat floor and a single zone of relative deepening (2.5 km) between Ladinhac and Sansac-Veinazès (fig. 10), interpreted as a possible root. For the Marcolès pluton the maximum depth (1.25 km) is located beneath the village of Marcolès. We propose the following model (fig. 11) for the emplacement of the Veinazès and Marcolès plutons during the late Namurian-early Stephanian time-span: initial opening of the crust corresponding to the present deepest parts of the plutons floor, led by ENE-WSW-trending left-lateral strike-slip faults (fig. 11a) magmatic ascent and accretion of the plutons (fig. 11b) about 40o clockwise rotation of the Marcolès pluton, the SW end of the Veinazès pluton and their country rocks, linked to a NNW-SSE right-lateral strike-slip band (fig. 11c). We consider that these events predate the low temperature sinistral movements along the NNE-SSW-trending Sillon Houiller during the Stephanian time. Conclusion. – The magmatic fabrics measured in the Veinazès and Marcolès plutons, combined with previous data from the country rocks, show the probable importance of transcurrent movements for the emplacement of these plutons. The rotation suffered by the western part of this region after granites were emplaced would need to be better contrained by palaeomagnetic measurements on the Marcolès pluton.
Publisher: Springer Berlin Heidelberg
Date: 2008
Publisher: ACM
Date: 08-09-2013
Publisher: Springer Berlin Heidelberg
Date: 2005
DOI: 10.1007/11536482_4
Publisher: JMIR Publications Inc.
Date: 12-06-2017
DOI: 10.2196/RESPROT.7172
Publisher: Public Library of Science (PLoS)
Date: 10-10-2012
Publisher: ACM
Date: 13-07-2015
Publisher: Cambridge University Press (CUP)
Date: 2015
Publisher: Springer Science and Business Media LLC
Date: 30-08-2000
Abstract: The specific impact of ischaemia on the myocardial kinetics of thallium-201 and technetium-99m 2-methoxy-2-isobutylisonitrile (MIBI) remains a matter of debate. Using an isolated heart model perfused with red blood cell-enhanced perfusate, we compared the overall first-pass kinetics of 201Tl and MIBI under haemodynamically stable conditions of low-flow ischaemia (> 50% reduction in normal coronary flow and a > or = 20 mmHg fall in systolic contraction pressure, n = 10) and normoxia (n = 11). For both 201Tl and MIBI, we found that under ischaemic conditions (as compared with normoxia) there was a higher initial net extraction fraction (201Tl: 0.78 +/- 0.03 vs 0.72 +/- 0.06, P = 0.006 MIBI: 0.49 +/- 0.10 vs 0.39 +/- 0.11, P = 0.03), a lower clearance rate in the 30 min following extraction (% decrease in cardiac uptake: 201Tl: 30 +/- 12 vs 47 +/- 14, P = 0.02 MIBI: 5 +/- 5 vs 13 +/- 11, P = 0.02) and a higher retention fraction at 30 min (20lTl: 0.54 +/- 0.10 vs 0.39 +/- 0.12, P = 0.004 MIBI: 0.46 +/- 0.08 vs 0.33 +/- 0.12, P = 0.01). Multivariate analyses, however, revealed that all myocardial kinetic parameters of both tracers were dependent only on coronary flow rates, without any additional significant impact of the presence of ischaemia or states of contractility or oxidative metabolism. We conclude that the myocardial fractional retention of both 201Tl and MIBI is strongly correlated with the decrease in coronary flow during ischaemia. This inverse relationship with coronary flow derives from both the flow-dependent increase in the initial myocardial extraction and the decrease in the subsequent myocardial washout of the tracers.
Publisher: Wiley
Date: 03-2019
Abstract: Communication training for parents of young children with neurodisability is often delivered in groups and includes video coaching. Group teaching is problematic when there is wide variation in the characteristics and needs amongst participants. To assess the potential feasibility and acceptability of delivering one-to-one parent training supported by remote coaching using smartphone apps and of conducting further trials of the intervention. We aimed to recruit eight children aged 12-48 months with motor disorders and communication difficulties and to provide families with in idual parent training in six weekly home visits supplemented by remote coaching via smartphone apps. For outcome measurement, parents recorded their interaction with their child thrice weekly during baseline (3 weeks), intervention, post-intervention (3 weeks) and follow-up (1 week). Measures comprised parent responsiveness and counts of children's communication and vocalization. Research design feasibility was measured through rates of recruitment, attrition, outcome measure completion and agreement between raters on outcome measurement. Intervention feasibility was assessed through the proportion of therapy sessions received, the number of videos and text messages shared using the apps in remote coaching, and message content. Parents were interviewed about the acceptability of the intervention and trial design. Interviews were transcribed and analyzed using inductive thematic analysis. Nine children were recruited over 16 weeks. All fitted the inclusion criteria. Four families withdrew from the study. Five families completed the intervention. No family submitted the target number of video recordings for outcome measurement. Interrater agreement was moderate for child communication (K = 0.46) and vocalization (K = 0.60) and high for The Responsive Augmentative and Alternative Communication Style scale (RAACS) (r The intervention and study design demanded high levels of parental involvement and was not suitable for all families. Recording shorter periods of interaction via mobile phones or using alternative methods of data collection may increase feasibility of outcome measurement.
Publisher: ACM
Date: 27-04-2013
Publisher: ACM
Date: 05-05-2012
Publisher: Oxford University Press (OUP)
Date: 09-06-2016
DOI: 10.1093/IWC/IWW017
Publisher: ACM
Date: 27-04-2013
Publisher: Institution of Engineering and Technology (IET)
Date: 2008
Publisher: ACM
Date: 18-04-2015
Publisher: ACM
Date: 15-02-2014
Publisher: ACM
Date: 27-06-2022
Publisher: Inderscience Publishers
Date: 2010
Publisher: Center for Open Science
Date: 17-09-2019
Abstract: It is widely acknowledged in design that culture is embodied in many aspects of an in idual’s identity. Many design methods operationalize this understanding through the use of cultural markers or predefined cultural dimensions. Here, we take a first step to distil the culturally specific values of the Saudi culture. We adopt a bottom-up approach that allows for values to emerge from the data by reflecting on two studies of a transnational population: a form of identity where the choice of cultural values is conscious and deliberate. Despite their different goals, the two studies yield common overarching core cultural values. Using a value-sensitive approach, we propose a process for designers to identify culturally specific values, illustrating this in our context of interest: Saudi culture.
Publisher: Springer Science and Business Media LLC
Date: 11-2016
DOI: 10.1057/S41271-016-0040-1
Abstract: Digital technology is increasingly used in humanitarian action and promises to improve the health and social well-being of populations affected by both acute and protracted crises. We set out to (1) review the current landscape of digital technologies used by humanitarian actors and affected populations, (2) examine their impact on health and well-being of affected populations, and (3) consider the opportunities for and challenges faced by users of these technologies. Through a systematic search of academic databases and reports, we identified 50 digital technologies used by humanitarian actors, and/or populations affected by crises. We organized them according to the stage of the humanitarian cycle that they were used in, and the health outcomes or determinants of health they affected. Digital technologies were found to facilitate communication, coordination, and collection and analysis of data, enabling timely responses in humanitarian contexts. A lack of evaluation of these technologies, a paternalistic approach to their development, and issues of privacy and equity constituted major challenges. We highlight the need to create a space for dialogue between technology designers and populations affected by humanitarian crises.
Publisher: ACM
Date: 16-02-2009
Publisher: ACM
Date: 19-04-2023
Publisher: IEEE
Date: 2011
Publisher: Springer Berlin Heidelberg
Date: 2011
Publisher: Elsevier BV
Date: 03-1989
DOI: 10.1016/0009-8981(89)90294-5
Abstract: A series of compounds derived from 7-acyl-(2H)-1,4-benzoxazin-3-(4H)-one was synthesized and evaluated for its lipid lowering actions in animal models. These of three 7-(2-methylene butyryl) 4-methyl and 2,4 dimethyl or 2,2,4 trimethyl benzoxazinone showed very potent activity. Their hypocholesterolemic and hypotriglyceridemic activities were tested in normolipemic and in cholesterol-induced hyperlipidemic mice, rats and Syrian hamsters. Two key enzymatic activities (ACAT, HMG CoA Reductase) of the most active compound were also determined. Additional investigation with these products and other derivatives will be performed using a variety of hepatic enzyme activities to better determine their mechanisms of action.
Publisher: Elsevier BV
Date: 10-1995
DOI: 10.1016/0735-1097(95)00243-9
Abstract: This study sought to evaluate the prognostic role of exercise thallium-201 (Tl-201) single-photon emission computed tomography (SPECT) in patients with known or suspected coronary artery disease. Compared with planar Tl-201 scintigraphy, Tl-201 SPECT allows enhanced assessment of myocardial perfusion abnormalities. However, the long-term prognostic value of exercise Tl-201 SPECT has not been ascertained and compared with that of other techniques of investigation. Predictors of ischemic events were sought in 217 patients with known or suspected coronary artery disease who underwent exercise Tl-201 SPECT, coronary angiography and rest radionuclide angiography and who initially received medical therapy. Predictive values were determined using Cox proportional hazards regression models. During a mean (+/- SD) follow-up period of 70 +/- 19 months, 29 patients had a major ischemic event (cardiac death or myocardial infarction). Total extent of exercise defects was the best independent predictor by Tl-201 SPECT of major events (p < 0.001) and provided additional prognostic information compared with clinical, exercise testing and catheterization variables (p < 0.02). Extent of reversible Tl-201 SPECT perfusion defects provided additional prognostic information compared with extent of irreversible defects (p < 0.001) and was the sole Tl-201 SPECT variable providing additional prognostic information compared with radionuclide left ventricular ejection fraction (p < 0.02). Total extent of exercise Tl-201 SPECT defects is a powerful long-term predictor of major ischemic events that enhances the prediction provided by clinical, exercise testing and coronary angiographic data. In view of its prognostic significance, extent of reversible Tl-201 SPECT defects might provide original information about improving prognosis by coronary revascularization.
Publisher: Springer Science and Business Media LLC
Date: 08-2015
Publisher: ACM
Date: 18-07-2007
Publisher: Elsevier BV
Date: 12-2007
DOI: 10.1016/J.NEUROSCIENCE.2007.09.030
Abstract: Perinatal brain injuries often result in irreversible learning disabilities, which manifest in early childhood. These injuries are chiefly ascribable to marked susceptibility of the immature brain to glutamate-induced excitotoxicity. No treatments are available. One well-characterized model of perinatal brain injuries consists in injecting the glutamate analog ibotenate into the brain of 5-day-old mice. The resulting excitotoxic lesions resemble the hypoxic-ischemic gray-matter lesions seen in full-term and near-term newborns, as well as the white-matter lesions of preterm newborns. We previously reported that these lesions disrupted odor preference conditioning in newborn mice. The aim of this study was to assess the effectiveness of the neuroprotector melatonin in preventing learning disabilities in newborn mice with ibotenate-induced brain injury. In postnatal day (P) 6-P7 pups, we tested psychomotor reflexes, spontaneous preference for maternal odors as an index of memory, ultrasonic vocalization responses to stroking as an index of sensitivity to tactile stimuli, and conditioned preference for an odor previously paired with stroking as an index of learning abilities. Without melatonin, conditioning was abolished, whereas spontaneous odor preference, psychomotor reflexes, and sensitivity to tactile stimuli were normal. Thus, abolition of conditioning was not associated with sensorimotor impairments. Histological analysis confirmed the efficacy of melatonin in reducing white-matter lesions induced by ibotenate. Furthermore, treatment with melatonin protected the ability to develop conditioning. Thus, melatonin, which easily crosses the blood-brain barrier and has been proven safe in children, may be effective in preventing learning disabilities caused by perinatal brain injuries in human preterm infants.
Publisher: MDPI AG
Date: 09-06-2016
DOI: 10.3390/NU8060358
Publisher: ACM
Date: 03-11-2014
Publisher: Springer Science and Business Media LLC
Date: 26-07-2007
Publisher: IEEE
Date: 1993
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 03-1993
DOI: 10.1109/42.222673
Abstract: Specific effects of the depth of interaction (DOI) on the photomultiplier (PM) response in an Auger gamma camera were quantified. The method was implemented and tested on a Monte Carlo simulator with special care to the noise modeling. Two models were developed, one considering only the geometric aspects of the camera and used for comparison, and one describing a more realistic camera environment. In a typical camera configuration and 140-keV photons, the DOI alone can account for a 6.4-mm discrepancy in position and 12% in energy between two scintillations. Variation of the DOI can still bring additional distortions when photons do not enter the crystal perpendicularly such as in slant hole, cone beam and other focusing collimators. With a 0.95-cm crystal and a 30 degrees slant angle, the obliquity factor can be responsible for a 5.5-mm variation in the event position. Results indicate that both geometrical and stochastic effects of the DOI are definitely reducing the camera performances and should be included in the image formation process.
Publisher: Springer Berlin Heidelberg
Date: 2011
Publisher: Springer Science and Business Media LLC
Date: 19-05-2009
Publisher: Wiley
Date: 11-07-2007
DOI: 10.1111/J.1472-8206.2007.00499.X
Abstract: Nefopam is widely used for the relief of moderate acute pain. Its safety profile remains to be specified. The objective of the study was to review adverse reactions to nefopam spontaneously reported to the French Pharmacovigilance system. All cases of adverse drug reactions (ADRs) associated with nefopam, registered in the French Pharmacovigilance database from January 1, 1995 to December 31, 2004, were reviewed. For each reported ADR, information about patient (age, gender, medical history), drug exposure (suspected and concomitantly used drugs), characteristics of ADRs (imputability score, time of onset, seriousness, outcome) were collected. A total of 114 ADRs with an imputability rated from 'plausible' (I2) to 'likely' (I3) and 'very likely' (I4) was analysed. The most frequent ADRs included 'expected' ADRs such as sweating, nausea, tachycardia, malaise or vomiting 61 ADRs were 'unexpected. No overdose was reported 26 ADRs (23%) were considered as 'serious'. Most of them were 'unexpected', including neuropsychiatric (hallucinations, convulsions) or cutaneous (pruritus, erythema, urticaria) ADRs. Six cases of anaphylactic ADRs (two angioedema and four anaphylactic shocks) were reported, all occurring shortly after use of nefopam during the post-operative period. Physicians should be aware of the possible occurrence of some serious ADRs when using nefopam such as convulsions and anaphylactic shocks, especially when the drug is used in special medical conditions, like post-operative periods.
Publisher: ACM
Date: 18-04-2015
Publisher: Springer Berlin Heidelberg
Date: 2004
Publisher: ACM
Date: 05-05-2012
Publisher: Elsevier BV
Date: 04-2014
DOI: 10.1016/J.GAITPOST.2014.01.008
Abstract: The Microsoft Kinect sensor (Kinect) is potentially a low-cost solution for clinical and home-based assessment of movement symptoms in people with Parkinson's disease (PD). The purpose of this study was to establish the accuracy of the Kinect in measuring clinically relevant movements in people with PD. Nine people with PD and 10 controls performed a series of movements which were measured concurrently with a Vicon three-dimensional motion analysis system (gold-standard) and the Kinect. The movements included quiet standing, multidirectional reaching and stepping and walking on the spot, and the following items from the Unified Parkinson's Disease Rating Scale: hand clasping, finger tapping, foot, leg agility, chair rising and hand pronation. Outcomes included mean timing and range of motion across movement repetitions. The Kinect measured timing of movement repetitions very accurately (low bias, 95% limits of agreement 0.9 and Pearson's r>0.9). However, the Kinect had varied success measuring spatial characteristics, ranging from excellent for gross movements such as sit-to-stand (ICC=.989) to very poor for fine movement such as hand clasping (ICC=.012). Despite this, results from the Kinect related strongly to those obtained with the Vicon system (Pearson's r>0.8) for most movements. The Kinect can accurately measure timing and gross spatial characteristics of clinically relevant movements but not with the same spatial accuracy for smaller movements, such as hand clasping.
Publisher: ACM
Date: 07-05-2016
Publisher: Springer Berlin Heidelberg
Date: 2013
Publisher: American Geophysical Union (AGU)
Date: 04-1995
DOI: 10.1029/94WR03390
Publisher: Cold Spring Harbor Laboratory
Date: 08-09-2023
Publisher: ACM
Date: 19-04-2023
Publisher: SAGE Publications
Date: 07-1991
DOI: 10.3109/10915819109078639
Abstract: Beta-cyclodextrin (BCD) was administered in the diet to male and female OFA rats derived from a Sprague-Dawley strain. Rats were fed a standard semisynthetic diet, UAR 210, containing 1.25% BCD, 2.5% BCD, 5% BCD, 10% BCD, and 10% lactose. Twenty animals/sex/group were dosed for 90 consecutive days. One animal died in the course of the study, but there was no indication that the death was compound-related. There were no dose-related adverse effects pertaining to hematology, blood, or urine chemistry. A small fraction of BCD was recovered in the urine of animals fed 5% or 10% BCD, amounting to 0.1–0.3% of the highest administered dose. The absolute and relative filled cecal weights of the rats that were fed BCD or lactose were increased in both the males and females, which is common in rats receiving slowly digestible fermentable carbohydrates due to incomplete digestion in the small intestine. No treatment-related effects indicative of a toxicologic response were found from the histopathologic examination. Based on these findings, BCD appears to lack toxicologic activity.
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Start Date: 2008
End Date: 2012
Funder: Economic and Social Research Council
View Funded ActivityStart Date: 2015
End Date: 2020
Funder: Engineering and Physical Sciences Research Council
View Funded ActivityStart Date: 2011
End Date: 2013
Funder: Economic and Social Research Council
View Funded ActivityStart Date: 2014
End Date: 2017
Funder: Engineering and Physical Sciences Research Council
View Funded ActivityStart Date: 2010
End Date: 2012
Funder: Microsoft Research
View Funded ActivityStart Date: 2010
End Date: 2012
Funder: Engineering and Physical Sciences Research Council
View Funded ActivityStart Date: 2012
End Date: 2016
Funder: Medical Research Council
View Funded ActivityStart Date: 2012
End Date: 2016
Funder: European Commission
View Funded ActivityStart Date: 05-2023
End Date: 05-2028
Amount: $4,583,816.00
Funder: Australian Research Council
View Funded Activity