ORCID Profile
0000-0002-5426-9545
Current Organisation
King's College London
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Publisher: Frontiers Media SA
Date: 29-09-2020
Publisher: Elsevier BV
Date: 06-2019
Publisher: Cold Spring Harbor Laboratory
Date: 24-10-2020
DOI: 10.1101/2020.10.24.353284
Abstract: In vitro , developing neurons progress through well-defined stages to form an axon and multiple dendrites. In vivo , neurons are derived from progenitors within a polarised neuroepithelium and it is not clear how axon initiation observed in vitro relates to what occurs in a complex, three-dimensional in vivo environment. Here we show that the position of axon initiation in embryonic zebrafish spinal neurons is extremely consistent across neuronal sub-types. We investigated what mechanisms may regulate axon positioning in vivo and found that microtubule organising centres are located distant from the site of axon initiation in contrast to that observed in vitro , and that microtubule plus-ends are not enriched in the axon during axon initiation. F-actin accumulation precedes axon formation and nascent axons form but are not stabilised in the absence of microtubules. Laminin depletion removes a spatial cue for axon initiation but axon initiation remains robust.
Publisher: MDPI AG
Date: 26-03-2020
DOI: 10.3390/JDB8020008
Abstract: Maintenance of the neural progenitor pool during embryonic development is essential to promote growth of the central nervous system (CNS). The CNS is initially formed by tightly compacted proliferative neuroepithelial cells that later acquire radial glial characteristics and continue to ide at the ventricular (apical) and pial (basal) surface of the neuroepithelium to generate neurons. While neural progenitors such as neuroepithelial cells and apical radial glia form strong connections with their neighbours at the apical and basal surfaces of the neuroepithelium, neurons usually form the mantle layer at the basal surface. This review will discuss the existing evidence that supports a role for neurons, from early stages of differentiation, in promoting progenitor cell fates in the vertebrates CNS, maintaining tissue homeostasis and regulating spatiotemporal patterning of neuronal differentiation through Delta-Notch signalling.
Publisher: EMBO
Date: 04-10-2022
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Rachel E Moore.