ORCID Profile
0000-0003-4652-5358
Current Organisations
University Medical Center Hamburg-Eppendorf
,
University of Cambridge
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Publisher: American Diabetes Association
Date: 06-08-2010
DOI: 10.2337/DC10-1150
Abstract: Whole-grain foods are touted for multiple health benefits, including enhancing insulin sensitivity and reducing type 2 diabetes risk. Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with fasting glucose and insulin concentrations in in iduals free of diabetes. We tested the hypothesis that whole-grain food intake and genetic variation interact to influence concentrations of fasting glucose and insulin. Via meta-analysis of data from 14 cohorts comprising ∼48,000 participants of European descent, we studied interactions of whole-grain intake with loci previously associated in GWAS with fasting glucose (16 loci) and/or insulin (2 loci) concentrations. For tests of interaction, we considered a P value & .0028 (0.05 of 18 tests) as statistically significant. Greater whole-grain food intake was associated with lower fasting glucose and insulin concentrations independent of demographics, other dietary and lifestyle factors, and BMI (β [95% CI] per 1-serving-greater whole-grain intake: −0.009 mmol/l glucose [−0.013 to −0.005], P & 0.0001 and −0.011 pmol/l [ln] insulin [−0.015 to −0.007], P = 0.0003). No interactions met our multiple testing–adjusted statistical significance threshold. The strongest SNP interaction with whole-grain intake was rs780094 (GCKR) for fasting insulin (P = 0.006), where greater whole-grain intake was associated with a smaller reduction in fasting insulin concentrations in those with the insulin-raising allele. Our results support the favorable association of whole-grain intake with fasting glucose and insulin and suggest a potential interaction between variation in GCKR and whole-grain intake in influencing fasting insulin concentrations.
Publisher: Springer Science and Business Media LLC
Date: 05-02-2012
DOI: 10.1038/NG.1081
Publisher: Copernicus GmbH
Date: 28-03-2022
DOI: 10.5194/EGUSPHERE-EGU22-12205
Abstract: & & The Southeast Asia (SEA) region is tectonically very active as it accommodates the northward movement of the Indo-Australian plate in the south and the westward movement of the Philippine Sea plate in the east. Borneo and Sulawesi are located in the centre of SEA, which is our area of interest. Borneo has an intraplate setting, while Sulawesi is situated above several microplate boundaries. For that reason, Sulawesi is seismically and volcanically more active than Borneo. The tectonic link and evolution between the two islands are not well understood as we are missing some fundamental knowledge, such as the variations in their crustal thickness and structure. This includes the provenance of their respective lithosphere, which may have Eurasian and/or East Gondwana origin.& & & & Here, we show the results obtained from the receiver function (RF) study on seismic stations in the region to have a better understanding of the crust and mantle lithosphere beneath the two islands. The RF study includes H-k stacking, time-depth migration of the RF and inversion to estimate crustal thickness and the shear speed variation with depth. The finding from this study shows that the crust in Sulawesi is much more complex than that of Borneo. The crustal thickness gradually changes throughout Borneo, with northern Borneo having an overall thicker crust than other parts of the island. In Sulawesi, the crustal thickness is much more varied across small distances, especially along the northern and southern arms of the island.& & & & We also show some results from the Virtual Deep Seismic Sounding (VDSS) method, which we only applied to the seismic stations in northern Borneo. We used VDSS on Northern Borneo to learn more about its complex tectonic history, such as the two subduction episodes and a continent-continent collision in a recent geological time scale. Our finding reveals a band of alternating thick and thin crust striking NE-SW in this region, which we believed resulted from extensional tectonics related to the Sulu Sea basin opening in the Miocene.& &
Publisher: American Geophysical Union (AGU)
Date: 04-02-2022
DOI: 10.1029/2021GL096117
Abstract: We use two‐plane‐wave tomography with a dense network of seismic stations across Sabah, northern Borneo, to image the shear wave velocity structure of the crust and upper mantle. Our model is used to estimate crustal thickness and the depth of the lithosphere‐asthenosphere boundary (LAB) beneath the region. Calculated crustal thickness ranges between 25 and 55 km and suggests extension in a NW‐SE direction, presumably due to back‐arc processes associated with subduction of the Celebes Sea. We estimate the β‐factor to be 1.3–2, well below the initiation of seafloor spreading. The LAB is, on average, at a depth of 100 km, which is inconsistent with models that ascribe Neogene uplift to wholescale removal of the mantle lithosphere. Instead, beneath a region of Plio‐Pleistocene volcanism in the southeast, we image a region 50–100 km across where the lithosphere has thinned to km, supporting recent suggestions of lower lithospheric removal through a Rayleigh‐Taylor instability.
Publisher: American Geophysical Union (AGU)
Date: 03-2021
DOI: 10.1029/2020TC006573
Publisher: Public Library of Science (PLoS)
Date: 10-05-2012
Publisher: Springer Science and Business Media LLC
Date: 10-05-2009
DOI: 10.1038/NG.361
Publisher: Springer Science and Business Media LLC
Date: 19-06-2023
Publisher: Public Library of Science (PLoS)
Date: 10-03-2011
Publisher: Copernicus GmbH
Date: 27-03-2022
DOI: 10.5194/EGUSPHERE-EGU22-5344
Abstract: & & Subduction is the main driver of tectonic activity on Earth. Termination of subduction is followed by erse and unexpected tectonic activity, such as anomalous magmatism, exhumation, subsidence and subsequent rapid uplift. What fundamentally drives these processes remain enigmatic. A prime ex le of subduction termination can be found in northern Borneo (Malaysia), where subduction ceased in the late Miocene and was followed by puzzling tectonic activity, as reconstructed from geological and petrological evidence. Our current understanding of the subduction cycle cannot be reconciled with evidence of post-subduction tectonics in both the near-surface geology and mantle of northern Borneo.& & & & We use new passive-seismic data to image at unprecedent detail a sub-vertical lithospheric drip that developed as a Rayleigh-Taylor gravitational instability from the root of a volcanic arc, which formed above a subducting plate. We use thermo-mechanical simulations to reconcile these images with time-dependent dynamical processes within the crust and underlying mantle, following subduction termination. Our model predictions illustrate how significant extension from a downwelling lithospheric drip can thin the crust in an adjacent orogenic belt, causing lower crustal melting and possible exhumation of subcontinental material, which can explain core-complex formations seen in other areas of recent subduction termination.& &
Publisher: American Geophysical Union (AGU)
Date: 28-10-2022
DOI: 10.1029/2022GC010563
Abstract: We present a new 3‐D seismic structural model of the eastern Indonesian region and its surroundings from full‐waveform inversion (FWI) that exploits seismic data filtered at periods between 15–150 s. SASSY21 —a recent 3‐D FWI tomographic model of Southeast Asia—is used as a starting model, and our study region is characterized by particularly good data coverage, which facilitates a more refined image. We use the spectral‐element solver Salvus to determine the full 3‐D wavefield, accounting for the fluid ocean explicitly by solving a coupled system of acoustic and elastic wave equations. This is computationally more expensive but allows seismic waves within the water layer to be simulated, which becomes important for periods ≤20 s. We investigate path‐dependent effects of surface elevation (topography and bathymetry) and the fluid ocean on synthetic waveforms, and compare our final model to the tomographic result obtained with the frequently used ocean loading approximation. Furthermore, we highlight some of the key features of our final model— SASSIER22 —after 34 L‐BFGS iterations, which reveals detailed anomalies down to the mantle transition zone, including a convergent double‐subduction zone along the southern segment of the Philippine Trench, which was not evident in the starting model. A more detailed illumination of the slab beneath the North Sulawesi Trench reveals a pronounced positive wavespeed anomaly down to 200 km depth, consistent with the maximum depth of seismicity, and a more diffuse but aseismic positive wavespeed anomaly that continues to the 410 km discontinuity.
Publisher: Elsevier BV
Date: 09-2011
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Udo Seedorf.