ORCID Profile
0000-0002-0114-2460
Current Organisation
Princess Alexandra Hospital
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Publisher: The Endocrine Society
Date: 20-07-2020
Abstract: Riedel thyroiditis (RT) is a rare inflammatory autoimmune disease that is often a clinically diagnostic dilemma because of its insidious presentation and nonspecific symptoms. The aim of the present systematic review and meta-analysis is to clarify the presentation, management, and outcomes of RT. A systematic search of PubMed/MEDLINE and Web of Science was conducted to identify relevant reports published up to September 2019. First author, country, patient sex, ethnicity, presentation, biochemical status, duration of symptoms, histology, treatment, follow-up duration, and short- and long-term outcomes. Data from 212 RT patients were retrieved. The mean age was 47 years with a predominantly female population (81%). Neck swelling (89%), dyspnea (50%), and neck pain (41%) were the most common presenting symptoms. Inflammatory markers were elevated in 70% to 97% and thyroid antibody positivity was present in less than 50%. Up to 82% underwent surgical intervention, with the most common being total thyroidectomy in 34% of in iduals. Glucocorticoids were used in 70% of in iduals with median duration 3 months. Prognosis was reasonable with 90% having resolution or improvement of symptoms. This analysis is the largest and most comprehensive to date of RT and provides clinicians with vital information on the common presentation features that may alert to the diagnosis and highlight management options.
Publisher: Oxford University Press (OUP)
Date: 21-12-2022
DOI: 10.1093/CEI/UXAC115
Abstract: Type 1 diabetes and Graves’ disease are chronic autoimmune conditions, characterized by a dysregulated immune response. In Type 1 diabetes, there is beta cell destruction and subsequent insulin deficiency whereas in Graves’ disease, there is unregulated excessive thyroid hormone production. Both diseases result in significant psychosocial, physiological, and emotional burden. There are associated risks of diabetic ketoacidosis and hypoglycaemia in Type 1 diabetes and risks of thyrotoxicosis and orbitopathy in Graves’ disease. Advances in the understanding of the immunopathogenesis and response to immunotherapy in Type 1 diabetes and Graves’ disease have facilitated the introduction of targeted therapies to induce self-tolerance, and subsequently, the potential to induce long-term remission if effective. We explore current research surrounding the use of antigen-specific immunotherapies, with a focus on human studies, in Type 1 diabetes and Graves’ disease including protein-based, peptide-based, dendritic-cell-based, and nanoparticle-based immunotherapies, including discussion of factors to be considered when translating immunotherapies to clinical practice.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 11-2021
No related grants have been discovered for Yuqing Zheng.