ORCID Profile
0000-0002-0151-3110
Current Organisations
Syddansk Universitet
,
Umeå Universitet
,
SDU
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Publisher: ACM
Date: 03-07-2020
Publisher: ACM
Date: 03-07-2020
Publisher: ACM
Date: 02-05-2019
Publisher: figshare
Date: 2019
Publisher: ACM
Date: 27-04-2013
Publisher: ACM
Date: 30-05-2018
Publisher: ACM
Date: 29-11-2010
Publisher: MDPI AG
Date: 14-02-2020
DOI: 10.3390/MOLECULES25040830
Abstract: The use of natural products as chemotherapeutic agents is well established however, many of these are associated with undesirable side effects, including high toxicity and instability. Furthermore, the development of drug resistant cancers makes the search for new anticancer lead compounds a priority. In this study, the extraction of an Ircinia sp. sponge resulted in the isolation of an inseparable mixture of (7E,12E,20Z)-variabilin (1) and (7E,12Z,20Z)-variabilin (2) and structural assignment was established using standard 1D and 2D NMR experiments. The cytotoxic activity of the compound against three solid tumour cell lines displayed moderate anti-cancer activity through apoptosis, together with a general lack of selectivity among the cancer cell lines studied. Structural assignment and cytotoxic evaluation of variabilin was complicated and further aggravated by its inherent instability. Variabilin was therefore incorporated into solid lipid nanoparticles (SLNs) and the stability and cytotoxic activity evaluated. Encapsulation of variabilin into SLNs led to a marked improvement in stability of the natural product coupled with enhanced cytotoxic activity, particularly against the prostate (PC-3) cancer cell line, with IC50 values of 87.74 μM vs. 8.94 μM for the variabilin alone and Var-SLN, respectively. Both variabilin and Var-SLN revealed comparable activity to Ceramide against the MCF-7 breast cancer cell line, revealing IC50 values of 34.8, 38.1 and 33.6 μM for variabilin, Var-SLN and Ceramide, respectively. These s les revealed no activity ( μM for all) against HT-29 (colon) cell lines and MCF-12 (normal breast) cell lines. Var-SLNs induced 47, 48 and 59% of apoptosis in HT-29, MCF-7 and PC-3 cells, respectively, while variabilin alone revealed 38, 29 and 29% apoptotic cells for HT-29, MCF-7 and PC-3 cell lines, respectively. The encapsulation of natural products into SLNs may provide a promising approach to overcome some of the issues hindering the development of new anticancer drugs from natural products.
Publisher: Springer Science and Business Media LLC
Date: 25-06-2004
Publisher: Det Kgl. Bibliotek/Royal Danish Library
Date: 05-10-2015
Abstract: class="page" title="Page 1" class="layoutArea" class="column" span The value of engaging the full gamut of sensory motor skills in the design and use of smart objects and systems is recognized. Yet methods for arriving at robust and reliable outcomes for their development are not fully understood, nor are they easily reported or transferred through typical conference presentations and paper submissions. New forms of knowledge transfer, such as pictorials (e.g., DIS and RTD conferences), and video are enabling enhanced, image-enriched reporting of outcomes. Y et appropriate transfer of embodied research methods remains elusive. /span span In this workshop we propose to investigate how embodied research techniques may be used as direct and unmediated vehicles for their own reporting. Rather than engaging in oral presentations, participants will lead other participants through a proven embodied method or approach. Small groups will create mash-ups of techniques, exploring ways that the new approaches might coherently be reported. Participants will be encouraged to experiment with different recording techniques, including body-mounted sensing and recording devices, as well as less conventional approaches. The intention is to find appropriate ways of reporting embodied experiments, so that intangible elements are not lost. Participants will be supported to reflect on unfolding discoveries, to share impressions, as well as outcomes, including documentation experiments that aim to tangibly capture and communicate the processes undertaken. /span span Embodied ideation, communication and collaboration techniques enable enhanced creative engagement and assist creativity [2]. By applying such methods to the problem of their reporting, we hope to deepen understanding of how to move towards enriched, nuanced and repeatable methods for embodied design and knowledge transfer. Crucially, our intention is not simply to find the next form of research reporting. Rather, this workshop will engage participants in an experimental enquiry, so that embodied design research may become an active area of inquiry moving forward. /span / / /
Publisher: Elsevier BV
Date: 2020
Publisher: SAGE Publications
Date: 2022
DOI: 10.1177/18479804221108254
Abstract: Along with the increasing requirement for efficient organic conversions using green chemistry, there is a need to develop highly efficient and eco-friendly catalytic reaction systems. Gold nanoparticles (AuNPs)-based nanocatalysts are promising candidates for the reduction of environmental pollutants, such as nitroaromatics and dyes. This study reports on the green synthesis of AuNPs using Carpobrotus edulis (C. edulis) fruit aqueous extract (CeFE) and their catalytic activities. The CeFE induced rapid reduction of gold (III) salt to form monodispersed and spherical AuNPs, with a core and hydrodynamic sizes of 40 and 108.7 nm, respectively. CeFE alone had no effect on 4-nitrophenol, whereas incubation with methylene blue (MB) caused reduction of the peak at 665 nm. Addition of CeFE-AuNPs in the presence of NaBH 4 , caused the reduction of 4-nitrophenol to 4-AP, and MB to leucoMB within 10 min. These reactions followed the pseudo first-order kinetics. Therefore, biogenic CeFE-AuNPs could be used for the elimination of noxious environmental pollutants.
Publisher: ACM
Date: 22-06-2021
Publisher: ACM
Date: 17-10-2019
Publisher: Springer Science and Business Media LLC
Date: 17-06-2016
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9RA10872F
Abstract: Moxifloxacin was conjugated to polyethylene glycol to segregate host cell toxicity from antimicrobial activity. The conjugate was then encapsulated into a polycaprolactone nanoparticle to assist the simultaneous delivery of multiple drugs to the site of microbial infection.
Publisher: Walter de Gruyter GmbH
Date: 2011
Publisher: ACM
Date: 24-08-2015
Publisher: Association for Computing Machinery (ACM)
Date: 27-12-2021
DOI: 10.1145/3494974
Abstract: Wearable technologies draw on a range of disciplines, including fashion, textiles, HCI, and engineering. Due to differences in methodology, wearables researchers can experience gaps or breakdowns in values, goals, and vocabulary when collaborating. This situation makes wearables development challenging, even more so when technologies are in the early stages of development and their technological and cultural potential is not fully understood. We propose a common ground to enhance the accessibility of wearables-related resources. The objective is to raise awareness and create a convergent space for researchers and developers to both access and share information across domains. We present CHIMERA, an online search interface that allows users to explore wearable technologies beyond their discipline. CHIMERA is powered by a Wearables Taxonomy and a database of research, tutorials, aesthetic approaches, concepts, and patents. To validate CHIMERA, we used a design task with multidisciplinary designers, an open-ended usability study with experts, and a usability survey with students of a wearables design class. Our findings suggest that CHIMERA assists users with different mindsets and skillsets to engage with information, expand and share knowledge when developing wearables. It forges common ground across ergent disciplines, encourages creativity, and affords the formation of inclusive, multidisciplinary perspectives in wearables development.
Publisher: ACM
Date: 21-06-2020
Publisher: Design Research Society
Date: 16-06-2022
Publisher: ACM
Date: 03-07-2020
Publisher: Elisava Barcelona School of Design and Engineering
Date: 27-07-2022
Abstract: This issue of Temes de Disseny focuses on the contribution of design in promoting caring for life in all its manifestations and for the environment. In other words, caring for the entire planet. At a time when human health is in the spotlight more than ever, it is important to consider design within an interplay of different disciplines as societies worldwide strive to meet the Sustainable Development Goals while staying within the planetary boundaries. The aim of this issue is to bring a series of design and research perspectives to the forefront to plant the seed for new ideas about what might help designers become agents of change in the global health landscape.
Publisher: ACM
Date: 24-08-2015
Publisher: Elsevier BV
Date: 02-2022
Publisher: Intellect
Date: 05-2008
DOI: 10.1386/PADM.4.1.7_1
Publisher: Intellect
Date: 04-2019
DOI: 10.1386/IJFD.4.1.3_1
Abstract: Socialization, eating and play are core activities that make us human. While they are often brought together, play theory suggests that their combination has unexplored potential in the context of gastronomy. Our research also indicates that a chef’s desire to control the meal may be a key impediment to developing dining experiences in which the diner’s playful engagement impacts taste, texture and flavour combination. We investigate if combining participatory research through design and play theory might better situate chefs to ersify their approach to playful gastronomy. Using experimental design methods, we interviewed a chef, a maître d’, a professional gastronomist, two food enthusiasts and a novice, to identify overlooked opportunities to extend play in gastronomy. We then conducted a series of dinners – designed with and for experts, enthusiasts and novices – to explore these opportunities, and tested the resulting method through a workshop with student chefs and game designers. We present the method: Participatory Research through Gastronomy Design (PRGD), using the case of its development to explicate its characteristics. Our research suggests that PRGD supports the design of playful gastronomic experiences that appeal to a range of diners, affords exploration of play’s impact on social dynamics and can productively inform concrete design choices. It also – crucially – supports chefs to partially transfer control of how a meal unfolds, without diluting their sense of controlling the overall experience. PRGD thus addresses a key impediment to extending play in gastronomy. Gastronomy that responds to diners’ needs and desires for play are currently limited. We propose PRGD as an exciting – and viable – approach to address this limitation.
Publisher: ACM
Date: 19-08-2022
Publisher: ACM
Date: 19-08-2022
Publisher: Dobras
Date: 22-05-2018
DOI: 10.26563/DOBRAS.V11I23.718
Abstract: A indústria da moda é permeada por hiperconsumo. Produção em massa, preços baixos e tendências fazem com que consumidores percebam roupas como descartáveis. Essa cultura do descarte se soma aos já problemá- ticos impactos ambientais causados pela indústria. Para alterar esse cenário propomos intervenções em guarda-roupas, um método que parte de práticas experimentais em design para promover engajamentos mais ativos entre usuários e vestíveis, com suporte da noção de agência material. A partir de dois casos, usados para desenvolver e verificar o método, demonstramos como é possível intensificar valores presentes nas relações usuário-vestível através da percepção da agência das roupas, e, potencialmente, alterar ações de consumidores.
Publisher: ACM
Date: 06-07-2020
Publisher: ACM
Date: 06-07-2020
Publisher: ACM
Date: 16-02-2014
Publisher: Association for Computing Machinery (ACM)
Date: 09-2020
DOI: 10.1145/3411286
Publisher: ACM
Date: 14-02-2016
Publisher: Springer Science and Business Media LLC
Date: 07-2003
Publisher: Association for Computing Machinery (ACM)
Date: 05-2012
Publisher: MDPI AG
Date: 26-12-2017
Publisher: ACM
Date: 08-06-2018
Publisher: Association for Computing Machinery (ACM)
Date: 07-2011
Abstract: The boundaries between 'the digital' and our everyday physical world are dissolving as we develop more physical ways of interacting with computing. This forum presents some of the topics discussed in the colorful multidisciplinary field of tangible and embodied interaction. Eva Hornecker, Editor
Publisher: ACM
Date: 17-10-2019
Publisher: Association for Computing Machinery (ACM)
Date: 09-2020
DOI: 10.1145/3414471
Publisher: ACM
Date: 18-06-2019
Publisher: MDPI
Date: 21-06-2022
Publisher: ACM
Date: 15-01-1999
Location: United Kingdom of Great Britain and Northern Ireland
Location: Australia
Start Date: 2011
End Date: 2012
Funder: Australia Council for the Arts, Australian Government
View Funded ActivityStart Date: 2007
End Date: 2011
Funder: Commonwealth Scientific and Industrial Research Organisation
View Funded ActivityStart Date: 2017
End Date: 2021
Funder: European Cooperation in Science and Technology
View Funded ActivityStart Date: 2015
End Date: 2017
Funder: Erasmus+
View Funded ActivityStart Date: 2018
End Date: 2019
Funder: Nordic Culture Point
View Funded ActivityStart Date: 2012
End Date: 2014
Funder: Sidney Myer Fund and Myer Foundation
View Funded ActivityStart Date: 2017
End Date: 2018
Funder: H2020 European Research Council
View Funded ActivityStart Date: 2021
End Date: 2024
Funder: H2020 European Research Council
View Funded ActivityStart Date: 2014
End Date: 2017
Funder: Department of Education and Training
View Funded Activity