ORCID Profile
0000-0002-9555-8124
Current Organisations
Noakhali Science and Technology University Faculty of Pharmacy
,
University of New South Wales
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Publisher: Informa UK Limited
Date: 2018
Publisher: Bentham Science Publishers Ltd.
Date: 22-12-2015
Publisher: Medknow
Date: 11-2014
Publisher: Springer Science and Business Media LLC
Date: 07-05-2014
DOI: 10.1038/JA.2014.56
Abstract: The objective of this study was to determine the presence of ciprofloxacin and pharmacokinetics of ciprofloxacin in blood plasma of broiler chicken after single oral administration at feeding state. Ciprofloxacin was administered orally at 10 mg kg(-1) to each of the 10 broiler chickens at feeding state. Presence of ciprofloxacin was determined by TLC method and pharmacokinetics by HPLC method. Peak plasma concentration (Cmax) of ciprofloxacin, 0.26±0.03 mg l(-1) was achieved at 4.40±0.1 h (Tmax). Biological half-life of ciprofloxacin was 5.25±0.02 h. Area under the curve (AUC) was 13.397±0.13 mg ml(-1) h, elimination rate constant was 0.13±0.02 h(-1), volume of distribution was 0.194±0.04 l kg(-1) and bioavailability was 49±0.48%. On the basis of the results of the present study, we conclude that, feeding state may have a vital effect on the pharmacokinetic profile of ciprofloxacin in broiler blood plasma.
Publisher: PAGEPress Publications
Date: 20-12-2016
Abstract: The present study determined the susceptibility to ciprofloxacin of nalidixic acid resistant em Salmonella /em (NARS) isolated from enteric fever patients at Scheer Memorial Hospital, Banepa, Nepal, from June 2012 to December 2012. The antimicrobial sensitivity to nalidixic acid and ciprofloxacin was determined using modified Kirby-Bauer disc diffusion and broth dilution method according to the guidelines of the Clinical and Laboratory Standard Institute. em Salmonella /em was isolated from 34 out of 992 (3.43%) blood cultures collected during the study period, and 10 (29.4%) isolates were identified as em Salmonella enterica /em serotype Typhi, while 24 (70.6%) were identified as em Salmonella enterica /em serotype Paratyphi. Out of the total isolates, 31 (91.2%) were nalidixic acid-resistant em Salmonella /em (NARS). Among NARS, the minimum inhibitory concentration values for ciprofloxacin ranged from 0.25 to 2 mg/L and were constantly higher than those shown by the nalidixic acid-susceptible em Salmonella /em . Therefore, in typhoid em Salmonella /em nalidixic acid resistance may be the indicator of decreased susceptibility to ciprofloxacin.
Publisher: Springer Science and Business Media LLC
Date: 28-10-2014
Publisher: Marmara Pharmaceutical Journal
Date: 12-01-2018
DOI: 10.12991/MPJ.2018.47
Location: Bangladesh
No related grants have been discovered for Md. Mustahsan Billah.