Publication
Susceptibility to patterns of ciprofloxacin among nalidixic acid-resistant Salmonella isolates collected in Banepa, Nepal from enteric fever patients
Publisher:
PAGEPress Publications
Date:
20-12-2016
DOI:
10.4081/JBR.2016.5527
Abstract: The present study determined the susceptibility to ciprofloxacin of nalidixic acid resistant em Salmonella /em (NARS) isolated from enteric fever patients at Scheer Memorial Hospital, Banepa, Nepal, from June 2012 to December 2012. The antimicrobial sensitivity to nalidixic acid and ciprofloxacin was determined using modified Kirby-Bauer disc diffusion and broth dilution method according to the guidelines of the Clinical and Laboratory Standard Institute. em Salmonella /em was isolated from 34 out of 992 (3.43%) blood cultures collected during the study period, and 10 (29.4%) isolates were identified as em Salmonella enterica /em serotype Typhi, while 24 (70.6%) were identified as em Salmonella enterica /em serotype Paratyphi. Out of the total isolates, 31 (91.2%) were nalidixic acid-resistant em Salmonella /em (NARS). Among NARS, the minimum inhibitory concentration values for ciprofloxacin ranged from 0.25 to 2 mg/L and were constantly higher than those shown by the nalidixic acid-susceptible em Salmonella /em . Therefore, in typhoid em Salmonella /em nalidixic acid resistance may be the indicator of decreased susceptibility to ciprofloxacin.