ORCID Profile
0000-0001-9678-1187
Current Organisations
BeDimensional
,
Nanyang Technological University
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Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C6TA10572F
Abstract: Solution-processed H 2 -evolving hybrid organic PEC cells are boosted by using few-layer p-doped MoS 2 flakes as an efficient atomic-thick hole-selective layer.
Publisher: IEEE
Date: 07-2015
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C5TA08553E
Abstract: A binder-free graphene anode for Li-ion batteries showing a reversible specific capacity of ∼500 mA h g −1 after 100 cycles is demonstrated.
Publisher: Elsevier BV
Date: 12-2015
Publisher: Wiley
Date: 16-04-2018
Publisher: Springer Science and Business Media LLC
Date: 19-03-2021
DOI: 10.1038/S41522-021-00197-5
Abstract: Extracellular DNA, or eDNA, is recognised as a critical biofilm component however, it is not understood how it forms networked matrix structures. Here, we isolate eDNA from static-culture Pseudomonas aeruginosa biofilms using ionic liquids to preserve its biophysical signatures of fluid viscoelasticity and the temperature dependency of DNA transitions. We describe a loss of eDNA network structure as resulting from a change in nucleic acid conformation, and propose that its ability to form viscoelastic structures is key to its role in building biofilm matrices. Solid-state analysis of isolated eDNA, as a proxy for eDNA structure in biofilms, reveals non-canonical Hoogsteen base pairs, triads or tetrads involving thymine or uracil, and guanine, suggesting that the eDNA forms G-quadruplex structures. These are less abundant in chromosomal DNA and disappear when eDNA undergoes conformation transition. We verify the occurrence of G-quadruplex structures in the extracellular matrix of intact static and flow-cell biofilms of P. aeruginosa , as displayed by the matrix to G-quadruplex-specific antibody binding, and validate the loss of G-quadruplex structures in vivo to occur coincident with the disappearance of eDNA fibres. Given their stability, understanding how extracellular G-quadruplex structures form will elucidate how P. aeruginosa eDNA builds viscoelastic networks, which are a foundational biofilm property.
Publisher: American Chemical Society (ACS)
Date: 05-01-2018
Location: Italy
Location: Spain
Location: United States of America
No related grants have been discovered for Antonio Esau Del Rio Castillo.