Nglaa Ahmad

COVID-19 and global clothing retailers' responsibility to vulnerable workers: NGO counter-rhetoric

Publisher: Emerald

Date: 26-08-2021

DOI: 10.1108/AAAJ-08-2020-4794

Abstract: This article aims to examine how non-governmental organisations (NGOs)' narratives portray the vulnerability of workers in global clothing supply chains during the COVID-19 crisis. The research analyses the rhetoric in global clothing retailers' and NGOs' counter-rhetoric during the first seven months of 2020. During this period, retailers employed rhetorical strategies to legitimise irresponsible actions (corporate hegemony prevailed), while NGOs embraced forms of counter-rhetoric trying to delegitimise the retailers' logic, stressing the role of neoliberalism in worsening the situation. The authors contribute to the literature by providing new insight into the consequences of COVID-19 for retailers' neoliberal practices and the livelihood of workers in global supply chains. Findings of this study extend authors’ knowledge about retailers' COVID-19 measures: These have contributed to the plights of workers working for their supply factories in the global South.

Safety and Activity of Immune Checkpoint Inhibitors in People Living With HIV and Cancer: A Real-World Report From the Cancer Therapy Using Checkpoint Inhibitors in People Living With HIV-Internationa

Publisher: American Society of Clinical Oncology (ASCO)

Date: 20-07-2023

DOI: 10.1200/JCO.22.02459

Abstract: Compared with people living without HIV (PWOH), people living with HIV (PWH) and cancer have traditionally been excluded from immune checkpoint inhibitor (ICI) trials. Furthermore, there is a paucity of real-world data on the use of ICIs in PWH and cancer. This retrospective study included PWH treated with anti–PD-1- or anti–PD-L1-based therapies for advanced cancers. Kaplan-Meier method was used to estimate overall survival (OS) and progression-free survival (PFS). Objective response rates (ORRs) were measured per RECIST 1.1 or other tumor-specific criteria, whenever feasible. Restricted mean survival time (RMST) was used to compare OS and PFS between matched PWH and PWOH with metastatic NSCLC (mNSCLC). Among 390 PWH, median age was 58 years, 85% (n = 331) were males, 36% (n = 138) were Black 70% (n = 274) received anti–PD-1/anti–PD-L1 monotherapy. Most common cancers were NSCLC (28%, n = 111), hepatocellular carcinoma ([HCC] 11%, n = 44), and head and neck squamous cell carcinoma (HNSCC 10%, n = 39). Seventy percent (152/216) had CD4+ T cell counts ≥200 cells/µL, and 94% (179/190) had HIV viral load copies/mL. Twenty percent (79/390) had any grade immune-related adverse events (irAEs) and 7.7% (30/390) had grade ≥3 irAEs. ORRs were 69% (nonmelanoma skin cancer), 31% (NSCLC), 16% (HCC), and 11% (HNSCC). In the matched mNSCLC cohort (61 PWH v 110 PWOH), 20% (12/61) PWH and 22% (24/110) PWOH had irAEs. Adjusted 42-month RMST difference was –0.06 months (95% CI, –5.49 to 5.37 P = .98) for PFS and 2.23 months (95% CI, –4.02 to 8.48 P = .48) for OS. Among PWH, ICIs demonstrated differential activity across cancer types with no excess toxicity. Safety and activity of ICIs were similar between matched cohorts of PWH and PWOH with mNSCLC.

University Of Aberdeen

Location: United Kingdom of Great Britain and Northern Ireland

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The Ohio State University Comprehensive Cancer Center Arthur G James Cancer Hospital And Richard J Solove Research Institute

Location: United States of America

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