ORCID Profile
0000-0001-5261-8118
Current Organisations
Olivia Newton-John Cancer Wellness & Research Centre
,
Austin Health
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Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D2CC04813B
Abstract: A fluorine-18 labelled probe was developed to target bromodomain and extraterminal (BET) proteins for molecular imaging of cancer with positron emission tomography.
Publisher: Springer Science and Business Media LLC
Date: 09-11-2020
DOI: 10.1186/S41181-020-00104-X
Abstract: Oncrasin-1 is a small molecule which was identified from a screen of KRAS mutant cancer cells and has shown specificity for KRAS mutant cell killing. We aimed to develop a radiolabelled form of Oncrasin-1 to enable in-vivo imaging of mutant KRAS expression in malignant tumours. This work outlines the synthesis of 3 fluorinated derivatives and development of iodonium salt and boronic ester precursors for radiolabelling with the 18 F isotope. In our hands, synthesis of iodonium salts were not easily accessible due to the 3-carbaldehyde indole structure being preferentially oxidized by conditions required for iodonium salt formation, rather than benzyl iodide. Synthesis and radiolabelling of boronic acid pinacol ester precursors were successful, with the products being obtained in yields of 10.76% ± 0.96% ( n = 5), 14.7% ±8.58% ( n = 3) and 14.92% ±3.9% (n = 3) for 18 F KAM001, 18 F KAM002 and 18 F KAM003 respectively, with radiochemical purity of greater than 99%. The successful synthesis of these tracers has been undertaken utilizing boronic ester radio-fluorination methods and will allow for investigation of Oncrasin based molecules as potential diagnostics for cancers expressing mutant KRAS protein.
Publisher: Elsevier BV
Date: 07-2023
Publisher: BMJ
Date: 11-2021
Publisher: Springer Science and Business Media LLC
Date: 19-02-2021
Publisher: EDP Sciences
Date: 05-2021
DOI: 10.1051/0004-6361/202039975
Abstract: We measured the cross-correlation between galaxy weak lensing data from the Kilo Degree Survey (KiDS-1000, DR4) and cosmic microwave background (CMB) lensing data from the Atacama Cosmology Telescope (ACT, DR4) and the Planck Legacy survey. We used two s les of source galaxies, selected with photometric redshifts, (0.1 z B 1.2) and (1.2 z B 2), which produce a combined detection significance of the CMB lensing and weak galaxy lensing cross-spectrum of 7.7 σ . With the lower redshift galaxy s le, for which the cross-correlation was detected at a significance of 5.3 σ , we present joint cosmological constraints on the matter density parameter, Ω m , and the matter fluctuation litude parameter, σ 8 , marginalising over three nuisance parameters that model our uncertainty in the redshift and shear calibration as well as the intrinsic alignment of galaxies. We find our measurement to be consistent with the best-fitting flat ΛCDM cosmological models from both Planck and KiDS-1000. We demonstrate the capacity of CMB weak lensing cross-correlations to set constraints on either the redshift or shear calibration by analysing a previously unused high-redshift KiDS galaxy s le (1.2 z B 2), with the cross-correlation detected at a significance of 7 σ . This analysis provides an independent assessment for the accuracy of redshift measurements in a regime that is challenging to calibrate directly owing to known incompleteness in spectroscopic surveys.
Location: Australia
No related grants have been discovered for Alexander McDonald.