ORCID Profile
0000-0001-6129-5613
Current Organisations
Medical University of Vienna
,
University of Stuttgart
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In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Photonics and Electro-Optical Engineering (excl. Communications) | Optometry and Ophthalmology | Optical Technology | Optical Properties of Materials |
Expanding Knowledge in the Physical Sciences | Technological and Organisational Innovation
Publisher: American Association for the Advancement of Science (AAAS)
Date: 24-04-2020
Abstract: Skyrmions are stable topological textures that arise from solutions of the electromagnetic field. Because these “hedgehog”-like textures are robust, can be manipulated, and can interact, there is an interest in pursuing them for memory and logic applications. Skyrmions can also be generated in thin metal layers under optical excitation, but detailed information about the vectorial dynamics of these surface plasmon polariton skyrmions is so far lacking. Davis et al. used a time-resolved photoelectron vector microscope to image their spatiotemporal dynamics, piecing together movies as the skyrmions propagated across the surface of a perfect gold crystal. Access to dynamics with such high spatial and temporal resolution could help in controlling other nanophotonic systems. Science , this issue p. eaba6415
Publisher: Wiley
Date: 15-11-2013
Publisher: EMBO
Date: 29-09-2021
Publisher: American Chemical Society (ACS)
Date: 04-10-2017
DOI: 10.1021/ACS.NANOLETT.7B02235
Abstract: We use subcycle time-resolved photoemission microscopy to unambiguously distinguish optically triggered electron emission (photoemission) from effects caused purely by the plasmonic field (termed "plasmoemission"). We find from time-resolved imaging that nonlinear plasmoemission is dominated by the transverse plasmon field component by utilizing a transient standing wave from two counter-propagating plasmon pulses of opposite transverse spin. From plasmonic foci on flat metal surfaces, we observe highly nonlinear plasmoemission up to the fifth power of intensity and quantized energy transfer, which reflects the quantum-mechanical nature of surface plasmons. Our work constitutes the basis for novel plasmonic devices such as nanometer-confined ultrafast electron sources as well as applications in time-resolved electron microscopy.
Publisher: American Chemical Society (ACS)
Date: 21-02-2019
Publisher: Springer Science and Business Media LLC
Date: 20-07-2020
DOI: 10.1038/S41377-020-00365-W
Abstract: Preclinical and clinical diagnostics increasingly rely on techniques to visualize internal organs at high resolution via endoscopes. Miniaturized endoscopic probes are necessary for imaging small luminal or delicate organs without causing trauma to tissue. However, current fabrication methods limit the imaging performance of highly miniaturized probes, restricting their widespread application. To overcome this limitation, we developed a novel ultrathin probe fabrication technique that utilizes 3D microprinting to reliably create side-facing freeform micro-optics ( µm diameter) on single-mode fibers. Using this technique, we built a fully functional ultrathin aberration-corrected optical coherence tomography probe. This is the smallest freeform 3D imaging probe yet reported, with a diameter of 0.457 mm, including the catheter sheath. We demonstrated image quality and mechanical flexibility by imaging atherosclerotic human and mouse arteries. The ability to provide microstructural information with the smallest optical coherence tomography catheter opens a gateway for novel minimally invasive applications in disease.
Publisher: American Chemical Society (ACS)
Date: 09-07-2020
Publisher: Wiley
Date: 03-2022
Abstract: Multimodal microendoscopes enable co‐located structural and molecular measurements in vivo, thus providing useful insights into the pathological changes associated with disease. However, different optical imaging modalities often have conflicting optical requirements for optimal lens design. For ex le, a high numerical aperture (NA) lens is needed to realize high‐sensitivity fluorescence measurements. In contrast, optical coherence tomography (OCT) demands a low NA to achieve a large depth of focus. These competing requirements present a significant challenge in the design and fabrication of miniaturized imaging probes that are capable of supporting high‐quality multiple modalities simultaneously. An optical design is demonstrated which uses two‐photon 3D printing to create a miniaturized lens that is simultaneously optimized for these conflicting imaging modalities. The lens‐in‐lens design contains distinct but connected optical surfaces that separately address the needs of both fluorescence and OCT imaging within a lens of 330 µm diameter. This design shows an improvement in fluorescence sensitivity of x in contrast to more conventional fiber‐optic design approaches. This lens‐in‐lens is then integrated into an intravascular catheter probe with a diameter of 520 µm. The first simultaneous intravascular OCT and fluorescence imaging of a mouse artery in vivo is reported.
Publisher: American Chemical Society (ACS)
Date: 25-09-2017
Publisher: Springer Science and Business Media LLC
Date: 2023
DOI: 10.1038/S41377-022-01015-Z
Abstract: Manipulating light on the nanoscale has become a central challenge in metadevices, resonant surfaces, nanoscale optical sensors, and many more, and it is largely based on resonant light confinement in dispersive and lossy metals and dielectrics. Here, we experimentally implement a novel strategy for dielectric nanophotonics: Resonant subwavelength localized confinement of light in air. We demonstrate that voids created in high-index dielectric host materials support localized resonant modes with exceptional optical properties. Due to the confinement in air, the modes do not suffer from the loss and dispersion of the dielectric host medium. We experimentally realize these resonant Mie voids by focused ion beam milling into bulk silicon wafers and experimentally demonstrate resonant light confinement down to the UV spectral range at 265 nm (4.68 eV). Furthermore, we utilize the bright, intense, and naturalistic colours for nanoscale colour printing. Mie voids will thus push the operation of functional high-index metasurfaces into the blue and UV spectral range. The combination of resonant dielectric Mie voids with dielectric nanoparticles will more than double the parameter space for the future design of metasurfaces and other micro- and nanoscale optical elements. In particular, this extension will enable novel antenna and structure designs which benefit from the full access to the modal field inside the void as well as the nearly free choice of the high-index material for novel sensing and active manipulation strategies.
Publisher: Rockefeller University Press
Date: 22-02-2018
DOI: 10.1084/JEM.20171696
Abstract: Colorectal cancer is treated with antibodies blocking epidermal growth factor receptor (EGF-R), but therapeutic success is limited. EGF-R is stimulated by soluble ligands, which are derived from transmembrane precursors by ADAM17-mediated proteolytic cleavage. In mouse intestinal cancer models in the absence of ADAM17, tumorigenesis was almost completely inhibited, and the few remaining tumors were of low-grade dysplasia. RNA sequencing analysis demonstrated down-regulation of STAT3 and Wnt pathway components. Because EGF-R on myeloid cells, but not on intestinal epithelial cells, is required for intestinal cancer and because IL-6 is induced via EGF-R stimulation, we analyzed the role of IL-6 signaling. Tumor formation was equally impaired in IL-6−/− mice and sgp130Fc transgenic mice, in which only trans-signaling via soluble IL-6R is abrogated. ADAM17 is needed for EGF-R–mediated induction of IL-6 synthesis, which via IL-6 trans-signaling induces β-catenin–dependent tumorigenesis. Our data reveal the possibility of a novel strategy for treatment of colorectal cancer that could circumvent intrinsic and acquired resistance to EGF-R blockade.
Publisher: Springer Science and Business Media LLC
Date: 05-02-2019
DOI: 10.1038/S41467-019-08488-4
Abstract: Relativistic electron beams create optical radiation when interacting with tailored nanostructures. This phenomenon has been so far used to design grating-based and holographic electron-driven photon sources. It has been proposed recently that such sources can be used for hybrid electron- and light-based spectroscopy techniques. However, this demands the design of a thin-film source suitable for electron-microscopy applications. Here, we present a mesoscopic structure composed of an array of nanoscale holes in a gold film which is designed using transformation optics and delivers ultrashort chirped electromagnetic wave packets upon 30–200 keV electron irradiation. The femtosecond photon bunches result from coherent scattering of surface plasmon polaritons with hyperbolic dispersion. They decay by radiation in a broad spectral band which is focused into a 1.5 micrometer beam waist. The focusing ability and broadband nature of this photon source will initiate applications in ultrafast spectral interferometry techniques.
Publisher: American Association for the Advancement of Science (AAAS)
Date: 20-06-2018
DOI: 10.1126/SCITRANSLMED.AAO2301
Abstract: K-RAS –mutated lung adenocarcinomas depend on ERBB signaling, and pan-ERBB inhibitors impair K-RAS–driven lung tumorigenesis.
Location: Italy
Start Date: 05-2020
End Date: 08-2025
Amount: $450,000.00
Funder: Australian Research Council
View Funded Activity