ORCID Profile
0000-0001-7927-8395
Current Organisations
Vrije Universiteit Amsterdam
,
Consorzio Interuniversatario per lo Sviluppo dei Sistemi a Grande Interfase
,
Università degli Studi di Firenze
,
University of California Merced
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Publisher: Cold Spring Harbor Laboratory
Date: 16-04-2023
DOI: 10.1101/2023.04.14.536633
Abstract: Communication between cells located in different parts of an organism is often mediated by membrane-enveloped nanoparticles, such as extracellular vesicles (EVs). EV binding and cell uptake mechanisms depend on the heterogeneous composition of the EV membrane. From a colloidal perspective, the EV membrane interacts with other biological interfaces via both specific and non-specific interactions, where the latter include long-ranged electrostatic and van der Waals forces, and short-ranged repulsive “steric-hydration” forces. While electrostatic forces are generally exploited in most EV immobilization protocols, the roles played by various colloidal forces in controlling EV adsorption on surfaces have not yet been thoroughly addressed. In the present work, we study the interaction and adsorption of EVs with supported lipid bilayers (SLBs) carrying different surface charge densities. By probing the EV-SLB interaction using quartz crystal microbalance with dissipation monitoring (QCM-D) and confocal laser scanning microscopy (CLSM), we demonstrate that EV adsorption onto lipid membranes can be controlled by varying the strength of electrostatic forces. We then model the observed phenomena within the framework of nonlinear Poisson-Boltzmann theory. Modelling results confirm the experimental observations and highlight the crucial role played by attractive electrostatics in EV adsorption onto lipid membranes. Our results provide new fundamental insights into EV-membrane interactions and could be useful for developing novel EV separation and immobilization strategies.
Publisher: Proceedings of the National Academy of Sciences
Date: 15-08-2005
Abstract: The anthropogenic introduction of exotic species is one of the greatest modern threats to marine bio ersity. Yet exotic species introductions remain difficult to predict and are easily misunderstood because knowledge of natural dispersal patterns, species ersity, and biogeography is often insufficient to distinguish between a broadly dispersed natural population and an exotic one. Here we compare a global molecular phylogeny of a representative marine meroplanktonic taxon, the moon-jellyfish Aurelia , with natural dispersion patterns predicted by a global biophysical ocean model. Despite assumed high dispersal ability, the phylogeny reveals many cryptic species and predominantly regional structure with one notable exception: the globally distributed Aurelia sp.1, which, molecular data suggest, may occasionally traverse the Pacific unaided. This possibility is refuted by the ocean model, which shows much more limited dispersion and patterns of distribution broadly consistent with modern biogeographic zones, thus identifying multiple introductions worldwide of this cryptogenic species. This approach also supports existing evidence that ( i ) the occurrence in Hawaii of Aurelia sp. 4 and other native Indo-West Pacific species with similar life histories is most likely due to anthropogenic translocation, and ( ii ) there may be a route for rare natural colonization of northeast North America by the European marine snail Littorina littorea , whose status as endemic or exotic is unclear.
Publisher: Wiley
Date: 05-10-2022
DOI: 10.1111/JBI.14481
Abstract: We consider the opportunities and challenges comparative phylogeography (CP) faces in the genomic age to determine: (1) how we can maximise the potential of big CP analyses to advance biogeographic and macroevolutionary theory and (2) what we can, and will struggle, to achieve using CP approaches in this era of genomics. World‐wide. All. We review the literature to discuss the future of CP ‐ particularly examining CP insights enabled by genomics that may not be possible for single species and/or few molecular markers. We focus on how geography and species' natural histories interact to yield congruent and incongruent patterns of neutral and adaptive processes in the context of both historical and recent rapid evolution. We also consider how CP genomic data are being stored, accessed, and shared. With the widespread availability of genomic data, the shift from a single‐ to a multi‐locus perspective is resulting in detailed historical inferences and an improved statistical rigour in phylogeography. However, the time and effort required for collecting co‐distributed species and accruing species‐specific ecological knowledge continue to be limiting factors. Bioinformatic skills and user‐friendly analytical tools, alongside the computational infrastructure required for big data, can also be limiting. Over the last ~35 years, there has been much progress in understanding how intraspecific genetic variation is geographically distributed. The next major steps in CP will be to incorporate evolutionary processes and community perspectives to account for patterns and responses among co‐distributed species and across temporal scales, including those related to anthropogenic change. However, the full potential of CP will only be realised if we employ robust study designs within a sound comparative framework. We advocate that phylogeographers adopt such consistent approaches to enhance future comparisons to present‐day findings.
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D1CP03201A
Abstract: Topological effects are key in driving nano-bio interface phenomena: the symmetry of the lipid membrane (cubic or lamellar) dictates the interaction mechanism, while nanoparticles shape (sphere or rod) modulates the interaction strength.
Publisher: Wiley
Date: 26-07-2021
DOI: 10.1111/JBI.14223
Abstract: Despite increasing awareness of issues affecting inclusivity, equity and ersity, change has been slow in science and academia, and gender disparities remain significant. Biogeography has not escaped this pattern. Here, we present a virtual issue compiling some of the most cited papers led by women that have been published in the Journal of Biogeography since 2009 in an effort to equalize visibility of women's influential work. We summarize leading gender disparities and their potential underlying causes, and present our motivation and methodology in compiling this issue. We further provide a blog, website and social media links to highlight the research of the authors whose work is showcased here. Highlighting influential contributions by women biogeographers is a small step towards equalizing visibility across genders. We hope that this virtual issue will also contribute in some way to creating a greater sense of belonging for women biogeographers.
Publisher: Wiley
Date: 05-06-2023
DOI: 10.1111/JBI.14630
Publisher: Springer Science and Business Media LLC
Date: 17-06-2014
Publisher: Oxford University Press (OUP)
Date: 02-2012
Publisher: Cold Spring Harbor Laboratory
Date: 29-03-2021
DOI: 10.1101/2021.03.29.437497
Abstract: Inverse bicontinuous cubic phase membranes are ubiquitous in nature but their properties and functions are still not fully understood. To shed light on this topic, we herein realize thin supported cubic phase lipid films, characterize their structure and provide the first study of the mechanical properties of these non-lamellar architectures.
Publisher: Elsevier BV
Date: 09-2007
DOI: 10.1016/J.TREE.2007.06.009
Abstract: Species invasions provide numerous unplanned and frequently, but imperfectly, replicated experiments that can be used to better understand the natural world. Classic studies by Darwin, Grinnell, Elton and others on these species-invasion experiments provided invaluable insights for ecology and evolutionary biology. Recent studies of invasions have resulted in additional insights, six of which we discuss here these insights highlight the utility of using exotic species as 'model organisms'. We also discuss a nascent hypothesis that might provide a more general, predictive understanding of invasions and community assembly. Finally, we emphasize how the study of invasions can help to inform our understanding of applied problems, such as extinction, ecosystem function and the response of species to climate change.
Location: Italy
No related grants have been discovered for Michael Dawson.