ARDC Research Link Australia

ORCID Profile
Orcid icon. 0000-0002-4459-2875

Current Organisations
TU Dresden , Sea Country Solutions , Technische Universität Dresden

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Publications

Publication

Identifying and mitigating potential risks for Marine Stewardship Council assessment and certification

Publisher: Elsevier BV

Date: 10-2016

DOI: 10.1016/J.FISHRES.2016.03.006

Publication

Key attributes related to fishery improvement project (FIP) effectiveness in promoting improvements towards sustainability

Publisher: Wiley

Date: 13-03-2019

DOI: 10.1111/FAF.12357

Publication

Virtual Ontogeny of Cortical Growth Preceding Mental Illness

Publisher: Elsevier BV

Date: 08-2022

DOI: 10.1016/J.BIOPSYCH.2022.02.959

Abstract: Morphology of the human cerebral cortex differs across psychiatric disorders, with neurobiology and developmental origins mostly undetermined. Deviations in the tangential growth of the cerebral cortex during pre erinatal periods may be reflected in in idual variations in cortical surface area later in life. Interregional profiles of group differences in surface area between cases and controls were generated using T1-weighted magnetic resonance imaging from 27,359 in iduals including those with attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, schizophrenia, and high general psychopathology (through the Child Behavior Checklist). Similarity of interregional profiles of group differences in surface area and prenatal cell-specific gene expression was assessed. Across the 11 cortical regions, group differences in cortical area for attention-deficit/hyperactivity disorder, schizophrenia, and Child Behavior Checklist were dominant in multimodal association cortices. The same interregional profiles were also associated with interregional profiles of (prenatal) gene expression specific to proliferative cells, namely radial glia and intermediate progenitor cells (greater expression, larger difference), as well as differentiated cells, namely excitatory neurons and endothelial and mural cells (greater expression, smaller difference). Finally, these cell types were implicated in known pre erinatal risk factors for psychosis. Genes coexpressed with radial glia were enriched with genes implicated in congenital abnormalities, birth weight, hypoxia, and starvation. Genes coexpressed with endothelial and mural genes were enriched with genes associated with maternal hypertension and preterm birth. Our findings support a neurodevelopmental model of vulnerability to mental illness whereby prenatal risk factors acting through cell-specific processes lead to deviations from typical brain development during pregnancy.

Publication