Grant Count
4
Highest Funding Involved
$860,000.00
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No related researchers have been discovered for organisation State University Of New York, Buffalo.
Start Date: 2016
End Date: 12-2019
Amount: $646,400.00
Summary: Molecular force sensing mechanisms of PIEZO channels. The aim of this project is to characterise the gating mechanism of Piezo mechanosensitive ion channels recently identified in animals and humans. Mechanotransduction is ancient, as indicated by the presence of mechanosensitive channels in bacteria where these channels are activated by the bilayer mechanism according to the force-from-lipids paradigm possibly applicable to gating of the Piezo channels as well. Piezo channels play a crucial rol .... Molecular force sensing mechanisms of PIEZO channels. The aim of this project is to characterise the gating mechanism of Piezo mechanosensitive ion channels recently identified in animals and humans. Mechanotransduction is ancient, as indicated by the presence of mechanosensitive channels in bacteria where these channels are activated by the bilayer mechanism according to the force-from-lipids paradigm possibly applicable to gating of the Piezo channels as well. Piezo channels play a crucial role in senses of touch and pain, and mutations in Piezo1 have been shown to cause Xerocytosis – a hereditary genetic disorder manifested in haemolytic anemia. This project aims to help answer fundamental questions in mechanotransduction in vertebrates. Read more Read less
Funder: Australian Research Council
View Funded ActivityStart Date: 02-2017
End Date: 12-2020
Amount: $300,000.00
Summary: A bio-inspired lightweight composite system for blast and impact protection. This project aims to develop a lightweight armour system that protects structural elements from extreme loads. Every day around the world, accidental and deliberate loads cost billions of dollars in damage and loss of life. The project’s composite system can concentrate material into areas most needed under impact loads and absorb and mitigate energy under blast. The anticipated outcomes of this project should be direct .... A bio-inspired lightweight composite system for blast and impact protection. This project aims to develop a lightweight armour system that protects structural elements from extreme loads. Every day around the world, accidental and deliberate loads cost billions of dollars in damage and loss of life. The project’s composite system can concentrate material into areas most needed under impact loads and absorb and mitigate energy under blast. The anticipated outcomes of this project should be directly applicable to designing, assessing and strengthening structures, including civilian buildings, defence structures, bridges and offshore and industrial facilities. Read more Read less
Funder: Australian Research Council
View Funded ActivityStart Date: 09-2013
End Date: 12-2017
Amount: $223,838.00
Summary: Emotional responses to comparisons in romantic relationships: implications for relationship wellbeing. This project will identify the nature of the emotions that stem from comparisons between romantic partners. It will reveal how these emotions in turn impact relationship dynamics and ultimately, relationship wellbeing. This research will provide important insights into the underlying processes that make some relationships thrive and others fail.
Funder: Australian Research Council
View Funded ActivityStart Date: 2020
End Date: 12-2023
Amount: $860,000.00
Summary: Force-from-lipids biophysical principle underlying mechanotransduction. The major aim of this project is to determine evolutionary conserved physical principles of mechanotransduction in living cells through structure and function studies of PIEZO mechanoreceptor channels playing a crucial role in senses such as touch and pain in animals and humans. Mutations in these channels can cause numerous genetic disorders, including hereditary anaemias and joint contractures. Since they have been shown t .... Force-from-lipids biophysical principle underlying mechanotransduction. The major aim of this project is to determine evolutionary conserved physical principles of mechanotransduction in living cells through structure and function studies of PIEZO mechanoreceptor channels playing a crucial role in senses such as touch and pain in animals and humans. Mutations in these channels can cause numerous genetic disorders, including hereditary anaemias and joint contractures. Since they have been shown to respond to mechanical stimuli in the same manner as mechanoreceptor channels of organisms from bacteria to humans the intended outcome of this project is to uncover the unifying principles of mechanotransduction anchored in the laws of physics and chemistry that have guided the force-dependent design of all life forms. Read more Read less
Funder: Australian Research Council
View Funded Activity