Structure and interactions of a disordered malaria surface protein: implications for antigenicity

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/637368

Funding Status
Closed

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Funded Activity Summary

Malaria is responsible for around 2 million deaths annually, many in children under 5 years of age. Merozoite surface protein 2 (MSP2) from Plasmodium falciparum is being developed as a vaccine candidate. We will investigate the structure of MSP2 in various environments, including when bound to inhibitory antibodies. Key goals are to understand how the disordered structure of MSP2 affects its interaction with the host immune system and how that information can be used to design better vaccines.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $511,020.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Immunology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Binding affinity | Disordered protein structure | Immune recognition | Immune response | Malaria | Malaria surface antigen | Monoclonal antibodies | Vaccine

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