Enhancing host defence against intracellular pathogens by preventing iNOS interaction with a negative regulator, SSB-2

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/637348

Funding Status
Closed

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Funded Activity Summary

Secretion of nitric oxide (NO) gas by immune cells is a critical defence mechanism for the killing of intracellular pathogens. Production of NO within cells is regulated by the enzyme iNOS. We propose that preventing iNOS from interacting with its natural inhibitor protein (SSB-2) would allow enhanced and prolonged iNOS expression leading to increased NO and increased killing of pathogens such as the mycobacterium tuberculosis and the Leishmania parasite.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $448,881.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Innate Immunity

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

SPRY domains | inducible nitric oxide synthase | infectious diseases | macrophage | mycobacterial infection | protein-protein interactions | protozoan parasitic disease | regulation of immune response | signalling | tuberculosis

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