Role of Bak and Bax membrane anchors in targeting and apoptotic pore formation.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/637337

Funding Status
Closed

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Funded Activity Summary

In cancer cells the normal process of cell death (called apoptosis) is defective, helping abnormal cells to grow and multiply unchecked. The Bak and Bax proteins are members of the Bcl-2 family of apoptosis regulators, and play a pivotal role in mediating cell death. By defining how these proteins form a pore in mitochondria, the point of no return in cell death, will help the development of novel anti-cancer agents that target the Bcl-2 family in general, and Bak and Bax in particular.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $352,319.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Development, Proliferation and Death

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Bax | anti-tumour agents | apoptosis | cancer biology | cancer treatment | cell killing | membrane protein | mitochondria | protein structure

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