Thymic epithelial cell apoptosis, Aire and autoimmune disease.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/637332

Funding Status
Closed

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Funded Activity Summary

Autoimmune diseases, like diabetes and multiple sclerosis are a significant disease burden. Their root cause is the failure of the immune system to distinguish between the body's own tissues and potential pathogens. We propose to study how potentially dangerous immune cells are destroyed in the thymus before they can develop. This research will significantly improve our understanding of how autoimmune diseases begin.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $470,799.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Autoimmunity

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

APECED | Addisons disease | Aire | Apoptosis | Autoimmune disease | Immunological tolerance | T-cell differentiation | Thymus | Tolerance | Type I diabetes

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