Dynamics of hERG inactivation gating

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/635520

Funding Status
Closed

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Funded Activity Summary

The hERG potassium ion channel is critical for the maintenance of the normal rhythm of the heartbeat. The aim of this study is to map the temporal sequence of the movements of different parts of the hERG K+ channel that regulate the opening and closing of the extracellular gate of the channel. To achieve this, we will use the powerful protein engineering technique of phi-value analysis, a technique that has never before been applied to voltage-gated ion channels.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $502,437.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cardiac arrhythmias | drug-induced long QT syndrome | hERG K+ channels | phi-value analysis | structure-function relationships | sudden cardiac death | voltage-clamp electrophysiology

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