Mechanosensitive channels: Antimicrobials, channelopathies and nanovalves for drug delivery

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/635513

Funding Status
Closed

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Funded Activity Summary

Liposomal drug delivery systems (LDDS) are one of the most advanced particulate drug carriers in modern medicine. The ultimate goal of this project is to optimize a nanotechnology approach for improved control of therapeutic drug delivery for chemotherapy. The approach is using bacterial mechanosensitive channel MscL designed to act as a molecular nanovalve for localised drug release.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $673,953.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Nanobiotechnology

ANZSRC Socio-Economic Objective (SEO)

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Other Keywords

Antimicrobials | Cancer chemotherapy | Channelopathies | Drug delivery systems | Electron microscopy | Ion channels | Lipid bilayers | Lipids | Patch clamping | Protein structure

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