Defining the genetic and environmental factors that cause abnormal vertebral segmentation during embryogenesis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/635500

Funding Status
Closed

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Funded Activity Summary

Many birth defects cause vertebral malformations along the spinal column. They originate as the fetus forms, and may be caused by gene mutation or environmental factors. Whilst studying one type of vertebral malformation we have found a genetic cause for 30% of cases. We will investigate the genetic and environmental cause of the remainder. We will look for new genes causing this disease, and use a mouse model to learn how low oxygen levels during pregnancy causes such malformations

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $724,147.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Developmental Genetics (incl. Sex Determination)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Abnormal Development | Birth Defects | Congenital defects | Defects in embryonic development | Genetic susceptibility | Hypoxia and malnutrition during pregnancy | Inherited disorders | Intracellular hypoxia | Mouse genetics | Notch signaling pathway

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