Role of the host fibrinolytic system in invasive group A streptococcal disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/635218

Funding Status
Closed

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Funded Activity Summary

The flesh-eating bacterium group A streptococcus (GAS) is estimated to cause 700 million cases of self-limiting disease, and 600,000 cases of serious invasive disease each year. Approximately 25% of invasive infections are fatal. We have shown that GAS are able to hijack the host fibrinolytoc system to cause severe invasive infections. We plan to further examine the details of how this contributes to GAS disease. This research may contribute to the future devlopment of new therapeutics.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $531,444.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Bacteriology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bacterial pathogen | infectious diseases | innate immunity | necrotising faciitis | plasminogen | streptococcal disease | streptococcal infection | streptococcal invasive diseases | streptococcus | toxic shock syndrome

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