The role of the cytoskeleton in communication between the L-type Ca2+ channel and the mitochondria in cardiac pathology

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/634501

Funding Status
Closed

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Funded Activity Summary

The L-type calcium channel is a protein in the membrane of heart muscle cells responsible for maintaining normal rhythm and contraction. We have shown that the channel can also regulate the function of the energy producing part of the cell (mitochondria). This occurs with the assistance of proteins that maintain cell architecture. We will test whether this association is altered in human disease where the cell architecture is disrupted to determine the mechanisms for poor energy supply.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $542,890.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

calcium | calcium channels | cardiac energetics | cardiac failure | cardiac hypertrophy | cardiomyopathy | cardiovascular physiology

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