Using microRNAs to modify cancer cell growth

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/634375

Funding Status
Closed

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Funded Activity Summary

Human brain, pancreatic and head and neck cancers all have a poor prognosis. A gene critically implicated in these cancers is the epidermal growth factor receptor (EGFR), a key target for new therapies. We have identified a microRNA as a key regulator of the EGFR pathway in these tumors. In this project, we will investigate the functional role of this microRNA in these tumors, and determine if it can work synergistically with other new therapies targeting the EGFR pathway to improve outcomes.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $607,251.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Biochemistry: Nucleic Acids

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Combining miRNAs with other anti-EGFR treatments | EGFR and Akt signaling | Epidermal growth factor receptor (EGFR) | Glioblastoma, pancreatic cancer, head and neck cancer | New pathways from mRNA, ncRNA, miRNA and proteomic profiling | Understanding cancer pathways controlled by miRNAs | Using miRNAs to reduce cancer cell growth | human cancer cell growth | microRNAs and RNA metabolism

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