Inhibitors of Src family kinase signalling

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/634352

Funding Status
Closed

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Funded Activity Summary

Leukaemia-cancer cells have altered biochemical properties resulting in their high rate of growth compared to normal cells. One of these is augmented activity of enzymes called tyrosine kinases including members of the Src family. One called Lyn has been implicated in several leukaemias as well as cancer. We have identified a novel mechanism of down-regulating this family of enzymes mediated by small proteins. These may allow us to develop novel therapeutics for cancer-leukaemia treatment.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $517,989.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Pharmacology and Pharmaceutical Sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Breast cancer | Colon cancer | Intracellular Signalling | Lymphocytic leukemia | Myeloid leukaemia | Phosphoprotein | Prostate cancer | Protein-protein interaction | Src-family tyrosine kinases | Ubiquitin-mediated proteolysis

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