Induction of senescence in cells that use the Alternative Lengthening of Telomeres (ALT) mechanism

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/633265

Funding Status
Closed

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Funded Activity Summary

Approximately 10-15% of all cancers depend on Alternative Lengthening of Telomeres (ALT) for their continuing growth. A key aspect of many successful cancer treatments is that they force cancer cells to undergo a form of permanent growth arrest called senescence. In this study we will investigate characteristics of ALT-positive cancer cells that may make them especially vulnerable to senescence. This may be exploited in the future as a therapeutic strategy for cancers that depend on ALT.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $474,048.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oncology and Carcinogenesis not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cancer | cancer biology | carcinogenesis | cell biology | mechanisms inhibiting cancer cell growth | telomeres | treatment of cancer | tumour suppressor gene

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