Reversing oxidative inhibition of the Na-K pump by beta3 adrenergic agonists: implications for heart failure therapy

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/633252

Funding Status
Closed

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Funded Activity Summary

Heart failure is a debilitating condition characterised by a decreased heart pump function. Raised Na+ levels and increased oxidative stress in cardiac cells are important in its causation. While traditional antioxidants are not useful in treatment, we have found that a group of drugs designed to induce weight loss can reverse oxidative inhibition of the mechanism that pumps Na+ out of heart cells. The effect of these drugs on the Na+ pumping mechanism and heart failure will be examined.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $533,541.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Adrenergic receptor | Cardiac hypertrophy | Congestive heart failure | Diabetes | Myocardial infarction | Oxygen free radicals | long-term complications of insulin dependent diabetes | sodium-potassium [ATPase]

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