Zebrafish Regulomics for Human Health

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/633010

Funding Status
Closed

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Funded Activity Summary

This proposal uses the zebra fish system, which it is uniquely suited to investigate the regulation of disease genes. In all of these diseases preliminary work has already been performed and screening assays have been developed in a previous project (ZF-MODELS). In addition, the project will investigate genetic abnormalities of the eye and visual processing, genetic pathways underlying tissue regeneration and repair, and homologs of human genes related to diabetes and obesity, as well as infectious disease and cancer. The Australian component will perform a systematic characterisation of enhancer elements of potential disease genes. This characterisation will build on the concept of genomic regulatory blocks (GRBs) which contain highly conserved non-coding elements (HCNEs) acting as long-range enhancers of developmental genes (recently discovered by T. Becker in the ZF-MODELS project).

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2014

Funding Scheme: Targeted Calls

Funding Amount: $644,035.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genome Structure and Regulation

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Development genes | diabetes | enhancer elements | genetic diease | inherited diseases

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