Improving the use of chemotherapy by targeting the inflammatory response

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/632848

Funding Status
Closed

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Funded Activity Summary

Patient differences in clearance of anti-cancer drugs have a major impact on the success of chemotherapy. Benefit is lost if the drug is cleared too rapidly, while slow elimination causes toxicity. We will use well characterised mouse models that mirror the human situation to study the causes and effects of reduced drug metabolism in cancer. The data will guide future human studies that will result in improved diagnostic and therapeutic interventions to improve the tolerance of chemotherapy.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $570,876.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Oncology and Carcinogenesis not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cancer | cancer chemotherapy | cytokines | drug clearance | drug disposition in disease states | drug metabolism | hepatic gene regulation | human pharmacology | pharmacokinetics | toxicity

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