Diabetes exacerbates non-alcoholic steato-hepatitis (NASH)

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/632822

Funding Status
Closed

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Funded Activity Summary

Non-alcoholic steato-hepatitis (NASH) is a common disease of liver inflammation and scarring, which may progress to cirrhosis or liver cancer. While type 2 diabetes causes a higher rate of NASH and more rapid NASH progression the reasons for this are not clear. We have developed a novel animal model of NASH with diabetes added to dietary induced obesity. We show that a growth factor is elevated in the affected livers. We plan to block the growth factor to see if we can prevent NASH worsening.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $565,695.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Endocrinology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Connective tissue growth factor | Diabetes | Fibrosis | Liver disease | Non Alcoholic Steato Hepatitis | Non alcoholic steatohepatitis | Obesity

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