Identification of the Mechanisms of Lipotoxicity within the Bone Marrow Milieu

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/632767

Funding Status
Closed

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Funded Activity Summary

Obesity and osteoporosis two major epidemics of our time. Bone and fat communicate with each other in two different ways. A hormonal communication links bone and fat in a positive manner. In contrast, at the local level, increasing levels of marrow fat with aging affect bone quality through the local release of toxic factors. We will identify these factors and will assess the potential reversibility of lipotoxicity in bone, as a new therapeutic approach to osteoporosis in the elderly.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $416,007.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Endocrinology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Aging | Fatty acids | Fractures | Lipotoxicity | Obesity | Osteoblasts | Osteoporosis

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