The molecular basis of G protein coupled transport

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/632703

Funding Status
Closed

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Funded Activity Summary

G proteins are molecular switches in all organisms, turning fundamental processes on and off . Defects in the functions of these switches can lead to severe diseases, such as cancer. Crucial details regarding the mechanism by which these switches are turned to on are still missing. This proposal will use a bacterial model system, with aims to provide structural and functional detail on the molecular mechanism of the switch in G proteins, and to extend this model to mammalian systems.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $495,938.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Bacterial pathogenes | Cancer | Development of antibiotics | G protein-coupled processes | Iron transport | Membrane protein | Membrane transport | X-ray crystallography

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