Alpha-2-Macroglobulin and the Transport and Uptake of the Hormone, Hepcidin

Funding Activity

Website
http://grants.uberresearch.com/501100000925/http://purl.org/au-research/grants/nhmrc/632698/The-role-of-alpha-2-macroglobulin-on-hepcidin-transportand-uptake

Funding Status
Closed

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Funded Activity Summary

Hepcidin is a peptide hormone that is a major regulator of iron metabolism. It has been suggested that hepcidin is free in the blood. However, we recently identified that hepcidin binds with alpha-2-macroglobulin (a2-M) in the plasma and this increases the efficacy of this peptide. The demonstration that a2-M plays a role in hepcidin biology will lead to a better understanding of hepcidin physiology, the development of methods for its measurement and improved treatment of iron related diseases.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $533,541.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Endocrinology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alpha-2-macroglobulin | Endocrine | Endocrinology | Hormone receptors | Hormone transport | Hormone-binding | Hormones | Metabolism | radiolabel binding studies

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