The fungal SEC14 secretory pathway and virulence

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/632634

Funding Status
Closed

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Funded Activity Summary

Invasive fungal infections are a serious, escalating health issue. They cause severe disease with high death rates and are very costly to the health system. Current drugs often have suboptimal efficacy and cause side effects. New drugs are needed urgently. Many fungi, including the AIDS-related pathogen, Cryptococcus neoformans, secrete phospholipase B (Plbp) to facilitate infection. We will identify and investigate the Plbp secretion pathway as a novel anti-fungal drug target.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $536,304.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Microbiology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Fungal molecular pathogenesis and virulence mechanisms | Fungal opportunistic infections - Cryptococcus neoformans | Fungal secretory pathways as a drug target | Host-pathogen interaction | Immunocompromised patient-AIDS | PGP3 (Global Health) | Phospholipase B enzymes | Phospholipid homeostasis | Secretion pathways-regulation-protein trafficking-Golgi | Targeted Gene Disruption

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