The mechanism of ccbe1 function during lymphangiogenesis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/631657

Funding Status
Closed

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Funded Activity Summary

Tumours induce the regional growth of lymphatic vessels (in a process termed lymphangiogenesis) and then spread (a process termed metastasis) via lymphatic vessels and lymph nodes. Inhibiting lymphangiogenesis can inhibit metastasis. We have identified a gene called ccbe1 that is essential for lymphangiogenesis during development. We aim to understand how this potential therapeutic target functions at the molecular level during lymphangiogenesis.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $502,437.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Developmental Genetics (incl. Sex Determination)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Development | Inflammation | Lymphatic | Lymphoedema | Metastasis | Model organism | Obesity | Vascular biology | Zebrafish | lymphatic disease

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