Preclinical optimisation of intrauterine transplantation of fetal mesenchymal stem cells for osteogenesis imperfecta.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/631641

Funding Status
Closed

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Funded Activity Summary

Osteogenesis imperfecta is a genetic disorder causing brittle bones and fractures. Currently there is no good treatment. Transplanting stem cells before birth should allow them to build healthy bones early in life. Despite promising effects in animals, stem cell uptake is too low to prevent all fractures and ameliorate pain and deformity. We are studying how to improve the uptake of stem cells given to the fetus and neonate, in order to develop a treatment suitable for eventual use in humans.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $600,932.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Foetal Development and Medicine

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Birth defects | Bone growth and fracture healing | Congenital skeletal defects | Fetal medicine | Fetal therapy | Osteogenesis | Osteogenesis imperfecta | Stem cell therapy | Stem cells | Transplantation

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