Investigating the role of the NR4A nuclear receptor family in melanocyte function and tumorigenesis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/631510

Funding Status
Closed

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Funded Activity Summary

Individuals with red hair and fair skin have a considerably greater risk of developing melanoma and non-melanoma skin cancer. Understanding the relationship that genes such as MC1R and NR4As have to skin functions such as tanning and protection from UV damage, will provide a greater insight into melanoma susceptibility and progression. Furthermore, understanding the role that abnormal NR4A regulation plays in melanoma formation will aid in the identification of new therapeutic targets.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $555,325.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene Expression (incl. Microarray and other genome-wide approaches)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

DNA repair | cancer predisposition | cancer-melanoma | cancer: mechanisms of growth, invasion, metastases | gene expression | melanocyte | melanoma | nuclear receptor | ultraviolet radiation exposure

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