Cytoplasmic DNA as a danger signal for mammalian cells

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/631472

Funding Status
Closed

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Funded Activity Summary

DNA in mammalian cells is contained within a structure known as the nucleus. The presence of DNA outside the nucleus in the cytoplasm of the cell is a sure sign that something is wrong, and may indicate the presence of a viral invader. In this case, the cell initiates anti-viral responses, including production of anti-viral proteins and death of the infected cell to stop replication of the virus. Lack of proper control of these responses may contibute to the autoimmune disease lupus.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $592,661.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Innate Immunity

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cancer biology | cell death-apoptosis | gene therapy | host-pathogen interaction | infectious disease | innate immunity | systemic lupus erythematosus | viral immunology | viral infection

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