Metallo-beta-lactamases: predicting and combating antibiotic resistance

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/631433

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

The increase of drug-resistant bacterial pathogens has become a major global health concern. Many pathogens employ a special enzyme, named metallo-beta-lactamase (MBL), to degrade antibiotics such as penicillin. No clinically useful inhibitors of this enzyme are available. We will use sophisticated techniques to predict and combat drug resistance of the MBL from Klebsiella pneumoniae, a pathogen associated in particular with hospital-acquired infections such as urinary tract infections.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $530,424.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Antibiotic resistance | Antibiotics | Bacterial infection | Bacterial pathogen | Drug resistant bacteria | Enzyme inhibition | NMR spectroscopy | Rational drug design | Urinary tract infection | X-ray crystallography

Related Links