Astrocyte Regulation of Ammonia and Glutamate in Neonatal Hypoxia-Ischaemia

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/631414

Funding Status
Closed

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Funded Activity Summary

Lack of oxygen is a common problem for newborn infants, ocurring during events such as a difficult labour, and can lead to brain damage. We have discovered that a protein in the brain which normally removes ammonia (a toxic product of metabolism) is rapidly lost after a brief period of low oxygen. We propose that a build up of ammonia in the brain may be a key damaging event in hypoxia-related brain injury, and that it will be ameniable to therapeutic intervention.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $523,804.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

brain asphyxia | excitotoxicity | glia | glutamine | hypoxia | hypoxia and malnutrition during pregnancy | hypoxic-ischaemic encephalopathy | neonatal | neuronal cell death

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