Identifying long-range regulatory elements of the breast cancer susceptibility gene, BRCA1

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/631381

Funding Status
Closed

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Funded Activity Summary

BRCA1 is a breast cancer susceptibility gene implicated in both familial and sporadic breast cancers. The mechanisms controlling BRCA1 expression are poorly understood. We will identify DNA sequences critical for regulation of the BRCA1 gene. We hypothesise that these regions are mutational hot spots conferring an increased breast cancer risk. A better understanding of the pathways responsible for promoting BRCA1-associated breast cancer will provide important diagnostic and treatment targets.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $612,842.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genome Structure and Regulation

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

BRCA1 | Breast cancer | Cancer susceptibility | Control of gene expression | Early diagnosis | Gene looping | Long-range regulatory elements | Transcriptional regulation | Tumour supressor genes

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