Reprogramming the renal epithelium to reinitiate nephrogenesis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/631362

Funding Status
Closed

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Funded Activity Summary

It has been shown that a mature cell type can be reprogrammed to a different type of cell in vivo via the introduction of genes critical during an earlier stage of organ development. In this way, new beta-islet cells in the pancreas can be made. In this study, we will use our understanding of kidney development to redirect the cells of the kidney tubules to dedifferentiate and form new nephrons. This may ultimately result in a regenerative strategy to treat chronic renal disease.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $636,199.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Regenerative Medicine (incl. Stem Cells and Tissue Engineering)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

chronic renal disease | developmental genes | gene delivery | kidney | lentiviral vector | nephrology | nephron endowment | organ growth and development | tissue regeneration | tissue repair

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