Regulation of calcium release channels (RyR2) in healthy and failing hearts

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/631052

Funding Status
Closed

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Funded Activity Summary

In striated muscle, the sarcoplasmic reticulum (SR) is the calcium store from which calcium release through ryanodine receptors (RyR2) is the key determinate of muscle force. We will develop an understanding of the complex functional changes in RyR2 that underlie adaptation of the heart to physiological stress (exercise) and functional changes associated with mal-adaptation in heart failure.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $337,632.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Ca2+ signalling | Cardiac physiology | excercise | excitation-contraction coupling | heart disease | heart failure | phosphorylation | ryanodine receptor

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