Alternate Splicing of tryptase genes regulates their specificity

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/630660

Funding Status
Closed

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Funded Activity Summary

Tryptases are enzymes implicated in inflammatory disorders including arthritis, inflammatory bowel disease (IBD) and asthma. Specific tryptase inhibitors are effective in treating these diseases. We have discovered that each human tryptase gene is processed into two different protein products via a mechanism called alternate splicing. We will investigate the structure and function of these.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2014

Funding Scheme: NHMRC Project Grants

Funding Amount: $294,250.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alternate Splicing | Tryptase | asthma | cancer | inflammation | inflammatory bowel disease | rheumatoid arthritis | substrate specificity

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