New mechanisms regulating S100 protein function in inflammation

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/630647

Funding Status
Closed

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Funded Activity Summary

This project will examine new ways which affect the major effector cells in allergic inflammation and asthma regulated by novel S100 protein mediators. We find a natural protein (S100A12) of the innate immune system, in cells in the lungs of patients with acute asthma. S100A12 activates mast cells to release mediators that trigger asthma attack. We will characterise the proteins with which this protein binds on the cell surface and and determine how this mediates their activation.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2014

Funding Scheme: NHMRC Project Grants

Funding Amount: $813,929.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Innate Immunity

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

ATP-synthase | S100 proteins | antibody and drug treatment | asthma, rheumatoid arthritis, atherosclerosis | biochemistry - protein peptide | inflammatory diseases | mast cells | mechanisms | receptors | structure-activity relationships

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