Hearing protection conferred by P2X2 receptor signaling in the cochlea

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/630618

Funding Status
Closed

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Funded Activity Summary

Hearing loss from noise damage and ageing is the principal sensory disability in our society. This project will determine the contribution of the P2X2 receptor to protection from noise-induced hearing loss. We have found that P2X2 knockout mice have minimal temporary threshold shift. We will investigate the physiological basis for this and determine why this mouse model has greater hearing loss with intense sound and faster age-related hearing loss compared with wildtype controls.

Funded Activity Details

Start Date: 01-01-2010

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $580,019.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Sensory Systems

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Noise-induced hearing loss | age-related hearing loss | auditory neuroscience | cochlea | deafness | effect of noise stress on hearing | hearing physiology | presbycusis | purinergic signaling | sensory disability

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